Abstract:
:Protein-protein interactions are a regulatory mechanism for a number of physiological and pathological cellular processes. Neurodegenerative diseases, such as AD (Alzheimer's disease), are associated with the accelerated production or delayed clearance of protein aggregates. Hence, inhibition of pathologic protein-protein interactions is a very attractive mechanism for drug development. This review focuses on a novel therapeutic strategy to inhibit the de novo formation of protein aggregates. Inspired by strategies used in Nature and optimized over millions of years of evolution, we have created a bifunctional molecule [SLF (synthetic ligand for FK506-binding protein)-CR (Congo Red)] that is able to block Abeta (amyloid beta) aggregation by borrowing the surface and steric bulk of a cellular chaperone.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Bose M,Gestwicki JE,Devasthali V,Crabtree GR,Graef IAdoi
10.1042/BST0330543keywords:
subject
Has Abstractpub_date
2005-08-01 00:00:00pages
543-7issue
Pt 4eissn
0300-5127issn
1470-8752pii
BST0330543journal_volume
33pub_type
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