Abstract:
:Hsk1 (homologue of Cdc7 kinase 1) of the fission yeast is a member of the conserved Cdc7 (cell division cycle 7) kinase family, and promotes initiation of chromosome replication by phosphorylating Mcm (minichromosome maintenance) subunits, essential components for the replicative helicase. Recent studies, however, indicate more diverse roles for Hsk1/Cdc7 in regulation of various chromosome dynamics, including initiation of meiotic recombination, meiotic chromosome segregation, DNA repair, replication checkpoints, centromeric heterochromatin formation and so forth. Hsk1/Cdc7, with its unique target specificity, can now be regarded as an important modulator of various chromosome transactions.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Matsumoto S,Masai Hdoi
10.1042/BST20130217subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1712-9issue
6eissn
0300-5127issn
1470-8752pii
BST20130217journal_volume
41pub_type
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