Abstract:
:The development of natural tissues, organs and bodies depends on mechanisms of patterning and of morphogenesis, typically (but not invariably) in that order, and often several times at different final scales. Using synthetic biology to engineer patterning and morphogenesis will both enhance our basic understanding of how development works, and provide important technologies for advanced tissue engineering. Focusing on mammalian systems built to date, this review describes patterning systems, both contact-mediated and reaction-diffusion, and morphogenetic effectors. It also describes early attempts to connect the two to create self-organizing physical form. The review goes on to consider how these self-organized systems might be modified to increase the complexity and scale of the order they produce, and outlines some possible directions for future research and development.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Davies JA,Glykofrydis Fdoi
10.1042/BST20200013subject
Has Abstractpub_date
2020-06-30 00:00:00pages
1177-1185issue
3eissn
0300-5127issn
1470-8752pii
225189journal_volume
48pub_type
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