Abstract:
:In T cell development, a pivotal decision-making stage, termed β-selection, integrates a TCRβ checkpoint to coordinate survival, proliferation and differentiation to an αβ T cell. Here, we review how transcriptional regulation coordinates fate determination in early T cell development to enable β-selection. Errors in this transcription control can trigger T cell acute lymphoblastic leukaemia. We describe how the β-selection checkpoint goes awry in leukaemic transformation.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Chann AS,Russell SMdoi
10.1042/BST20180414subject
Has Abstractpub_date
2019-08-30 00:00:00pages
1077-1089issue
4eissn
0300-5127issn
1470-8752pii
BST20180414journal_volume
47pub_type
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