Abstract:
:Targeting of protein kinases and phosphatases to the cytoskeleton enhances the regulation of many signalling events. Cytoskeletal signalling complexes facilitate this process by optimizing the relay of messages from membrane receptors to specific sites on the actin cytoskeleton. These signals influence fundamental cell properties such as shape, movement and division. Targeting of the cAMP-dependent kinase (protein kinase A) and other enzymes to this compartment is achieved through interaction with A-kinase-anchoring proteins (AKAPs). The present paper discusses recent progress on dissecting the biological role of WAVE1 (Wiskott-Alrich syndrome protein family verprolin homology protein 1), an AKAP that assembles a cytoskeletal transduction complex in response to signals that emanate from the low-molecular-mass GTPase, Rac.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Scott JDdoi
10.1042/bst0310087keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
87-9issue
Pt 1eissn
0300-5127issn
1470-8752journal_volume
31pub_type
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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