all-D proline-rich cell-penetrating peptides: a preliminary in vivo internalization study.

abstract：:The backbones of proteins form linear chains. In the case of some proteins, these chains can be characterized as forming linear open knots. The knot type of the full chain reveals only limited information about the entanglement of the chain since, for example, subchains of an unknotted protein can form knots and subch...

journal_title：Biochemical Society transactions

authors： Rawdon EJ,Millett KC,Sułkowska JI,Stasiak A

更新日期：2013-04-01 00:00:00

abstract：:We recently showed that transport of ergosterol from the ER (endoplasmic reticulum) to the sterol-enriched PM (plasma membrane) in yeast occurs by a non-vesicular (Sec18p-independent) mechanism that results in the equilibration of sterol pools in the two organelles [Baumann, Sullivan, Ohvo-Rekilä, Simonot, Pottekat, K...

journal_title：Biochemical Society transactions

authors： Sullivan DP,Ohvo-Rekilä H,Baumann NA,Beh CT,Menon AK

更新日期：2006-06-01 00:00:00

abstract：:Biomarkers are needed to screen multiple stages in the clinical pathway of Barrett's oesophagus patients; from disease diagnosis to risk stratification and predicting response to therapy. Routes to the identification of biomarkers have been recognized by known molecular features of the disease and more recently throug...

journal_title：Biochemical Society transactions

authors： Huang Q,Hardie LJ

更新日期：2010-04-01 00:00:00

abstract：:Post-transcriptional gene silencing (PTGS) has been successfully used to modify seed lipids in oilseed crops like soybean, canola and sunflower. Conventionally, PTGS has been induced by transforming the plants with either antisense or co-suppression constructs targeted against key seed lipid biosynthesis genes. A majo...

journal_title：Biochemical Society transactions

authors： Singh S,Green A,Stoutjesdijk P,Liu Q

更新日期：2000-12-01 00:00:00

abstract：:Biochemical, biophysical and biological studies of oligonucleotides containing lesions at defined sites provide a molecular basis for the effects of DNA lesions. dG (deoxyguanosine) is the most easily oxidized of the four native nucleotides. The chemical reactivity of dG correlates with compilations of mutations, whic...

journal_title：Biochemical Society transactions

authors： Greenberg MM

更新日期：2004-02-01 00:00:00

abstract：:CYP74C3 (cytochrome P450 subfamily 74C3), an HPL (hydroperoxide lyase) from Medicago truncatula (barrel medic), and CYP74A1, an AOS (allene oxide synthase) from Arabidopsis thaliana, are key membrane-associated P450 enzymes in plant oxylipin metabolism. Both recombinant detergent-free enzymes are monomeric proteins wi...

journal_title：Biochemical Society transactions

authors： Hughes RK,Belfield EJ,Casey R

更新日期：2006-12-01 00:00:00

abstract：:The mTOR (mammalian target of rapamycin) signalling pathway functions as a nutrient sensor, both in individual cells and, more globally, in organs such as the fat body in Drosophila and the hypothalamus in the rat. The activity of placental amino acid transporters is decreased in IUGR (intrauterine growth restriction)...

journal_title：Biochemical Society transactions

authors： Roos S,Powell TL,Jansson T

更新日期：2009-02-01 00:00:00

abstract：:The central role of VEGF (vascular endothelial growth factor A) in angiogenesis is dependent upon its ability to co-ordinately regulate multiple endothelial functions. The multifunctionality of VEGF at the cellular level results from its ability to initiate a diverse, complex and integrated network of signalling pathw...

journal_title：Biochemical Society transactions

authors： Zachary I

更新日期：2003-12-01 00:00:00

abstract：:Within the SulfoSYS (Sulfolobus Systems Biology) project, the effect of temperature on a metabolic network is investigated at the systems level. Sulfolobus solfataricus utilizes an unusual branched ED (Entner-Doudoroff) pathway for sugar degradation that is promiscuous for glucose and galactose. In the course of metab...

journal_title：Biochemical Society transactions

authors： Haferkamp P,Kutschki S,Treichel J,Hemeda H,Sewczyk K,Hoffmann D,Zaparty M,Siebers B

更新日期：2011-01-01 00:00:00

abstract：:Plant chloroplasts contain an intricate photosynthetic membrane system, the thylakoids, and are surrounded by two envelope membranes at which thylakoid lipids are assembled. The glycoglycerolipids mono- and digalactosyldiacylglycerol, and sulfoquinovosyldiacylglycerol as well as phosphatidylglycerol, are present in th...

journal_title：Biochemical Society transactions

authors： Wang Z,Benning C

更新日期：2012-04-01 00:00:00

abstract：:NMDARs (N-methyl-D-aspartate receptors) are considered to be a target for the inhibitory actions of ethanol. While profound inhibition of both native and recombinant NMDARs can be observed following the application of high concentrations of ethanol the levels of inhibition seen with lower concentrations of ethanol are...

journal_title：Biochemical Society transactions

authors： Otton HJ,Janssen A,Wyllie DJ

更新日期：2009-12-01 00:00:00

abstract：:Sterol regulatory element-binding proteins (SREBPs) are a family of transcription factors that regulate lipid homoeostasis. Three SREBP isoforms control the expression of more than 30 genes required for the biosynthesis of cholesterol, fatty acids, triacylglycerols and phospholipids. The unique regulation and activati...

journal_title：Biochemical Society transactions

authors： Horton JD

更新日期：2002-11-01 00:00:00

abstract：:In interphase plant cells, the actin cytoskeleton is essential for intracellular transport and organization. To fully understand how the actin cytoskeleton functions as the structural basis for cytoplasmic organization, both molecular and physical aspects of the actin organization have to be considered. In the present...

journal_title：Biochemical Society transactions

authors： Ketelaar T,van der Honing HS,Emons AM

更新日期：2010-06-01 00:00:00

abstract：:Starting shortly after parturition, and continuing throughout our lifetime, the gut microbiota coevolves with our metabolic and neurological programming. This symbiosis is regulated by a complex interplay between the host and environmental factors, including diet and lifestyle. Not surprisingly, the development of thi...

journal_title：Biochemical Society transactions

authors： Chambers SA,Townsend SD

更新日期：2020-06-29 00:00:00

abstract：:The driving force of the cell cycle is the activities of cyclin-dependent kinases (CDKs). Key steps in the regulation of the cell cycle therefore must impinge upon the activities of the CDKs. CDKs exert their functions when bound to cyclins that are expressed cyclically during the cell cycle. Polyamine biosynthesis va...

journal_title：Biochemical Society transactions

authors： Oredsson SM

更新日期：2003-04-01 00:00:00

abstract：:Mass spectrometry (MS) provides an impressive array of information about the structure, function and interactions of proteins. In recent years, many new developments have been in the field of native MS and these exemplify a new coming of age of this field. In this mini review, we connect the latest methodological and ...

journal_title：Biochemical Society transactions

authors： Allison TM,Bechara C

更新日期：2019-02-28 00:00:00

abstract：:The calcium-sensing receptor is a multimodal, multimetabolic sensor that mediates the feedback-dependent control of whole body calcium metabolism. Remarkably, in addition to its role in Ca(2+)(o) (extracellular Ca(2+)) sensing, the CaR (Ca(2+)-sensing receptor) also responds to L-amino acids. L-amino acids appear to a...

journal_title：Biochemical Society transactions

authors： Conigrave AD,Mun HC,Brennan SC

更新日期：2007-11-01 00:00:00

abstract：:Stimulus-response coupling in animal cells frequently involves the hydrolysis of PtdIns(4,5)P(2) which is catalysed by phosphoinositide-specific phospholipase C (PI-PLC). There is an increasing body of evidence for PI-PLC-based signalling in plant cells; however, the physiological role of this system remains poorly do...

journal_title：Biochemical Society transactions

authors： Coursol S,Pierre JN,Vidal J

更新日期：2000-12-01 00:00:00

abstract：:The process of tRNA splicing entails removal of an intron by TSEN (tRNA-splicing endonuclease) and ligation of the resulting exon halves to generate functional tRNAs. In mammalian cells, the RNA kinase CLP1 (cleavage and polyadenylation factor I subunit) associates with TSEN and phosphorylates the 3' exon at the 5' en...

journal_title：Biochemical Society transactions

authors： Mair B,Popow J,Mechtler K,Weitzer S,Martinez J

更新日期：2013-08-01 00:00:00

abstract：:Sam68 (Src-associated in mitosis 68 kDa) is the prototypical member of the STAR (signal transducer and activator of RNA) family of RNA-binding proteins. Sam68 is implicated in a number of cellular processes including signal transduction, transcription, RNA metabolism, cell cycle regulation and apoptosis. In the presen...

journal_title：Biochemical Society transactions

authors： Rajan P,Gaughan L,Dalgliesh C,El-Sherif A,Robson CN,Leung HY,Elliott DJ

更新日期：2008-06-01 00:00:00

abstract：:In order to achieve greater selectivity in drug discovery, researchers in both academia and industry are targeting cell regulatory systems. This often involves targeting the protein-protein interactions of regulatory multiprotein assemblies. Protein-protein interfaces are widely recognized to be challenging targets as...

journal_title：Biochemical Society transactions

authors： Abdel-Rahman N,Martinez-Arias A,Blundell TL

更新日期：2011-10-01 00:00:00

abstract：:Frequent subversion of the PI3K (phosphoinositide 3-kinase) pathway during neoplastic transformation contributes to several hallmarks of cancer that result in a competitive advantage for cancer cells. Deregulation of this pathway can be the result of genomic alterations such as PIK3CA mutation, PTEN (phosphatase and t...

journal_title：Biochemical Society transactions

authors： Leroy C,Amante RJ,Bentires-Alj M

更新日期：2014-08-01 00:00:00

abstract：:The axial ligand of the catalytic mononuclear T1 copper site (Met(502)) of the CotA laccase was replaced by a leucine or phenylalanine residue to increase the redox potential of the enzyme. These mutations led to an increase in the redox potential by approx. 100 mV relative to the wild-type enzyme but the catalytic co...

journal_title：Biochemical Society transactions

authors： Melo EP,Fernandes AT,Durão P,Martins LO

更新日期：2007-12-01 00:00:00

abstract：:The Wilms' tumour-suppressor gene (WT1), encodes a zinc-finger transcription factor that is critical for the development of several organs, including the kidneys, gonads and spleen. Despite its identification as a tumour suppressor that plays a crucial role in the formation of a paediatric malignancy of the kidneys (W...

journal_title：Biochemical Society transactions

authors： Hartkamp J,Roberts SG

更新日期：2008-08-01 00:00:00

abstract：:Solid-state nuclear magnetic resonance (ssNMR) is an indispensable tool for elucidating the structure and dynamics of insoluble and non-crystalline biomolecules. The recent advances in the sensitivity-enhancing technique magic-angle spinning dynamic nuclear polarization (MAS-DNP) have substantially expanded the territ...

journal_title：Biochemical Society transactions

authors： Chakraborty A,Deligey F,Quach J,Mentink-Vigier F,Wang P,Wang T

更新日期：2020-06-30 00:00:00

abstract：:The action of VEGF (vascular endothelial growth factor) is essential to maintain proper endothelial and vascular function. VEGF stimulates virtually all aspects of endothelial function, namely proliferation, migration, permeability and nitric oxide production and release. In addition, the action of VEGF makes the endo...

journal_title：Biochemical Society transactions

authors： Waltenberger J

更新日期：2009-12-01 00:00:00

abstract：:Multiple cellular proteins have been identified as participating in Toll/interleukin-1 receptor-mediated inflammatory gene expression. The continuing isolation of novel components, based on sequence similarities, protein-protein interactions and protein purification, suggests that many elements of this signalling netw...

journal_title：Biochemical Society transactions

authors： Kiss-Toth E,Wyllie DH,Holland K,Marsden L,Jozsa V,Oxley KM,Polgar T,Qwarnstrom EE,Dower SK

更新日期：2005-12-01 00:00:00

abstract：:The intestinal epithelium represents one of our most important interfaces with the external environment. It must remain tightly balanced to allow nutrient absorption, but maintain barrier function and immune homoeostasis, a failure of which results in chronic infection or debilitating inflammatory bowel disease (IBD)....

journal_title：Biochemical Society transactions

authors： Worthington JJ

更新日期：2015-08-01 00:00:00

abstract：:VEGFs (vascular endothelial growth factors) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in adults. This family of five mammalian ligands acts through three RTKs (receptor tyrosine kinases). In addition, co-receptors such as NRPs (neuropilins) assoc...

journal_title：Biochemical Society transactions

authors： Koch S

更新日期：2012-02-01 00:00:00

abstract：:High glucose inhibits mitochondrial respiration, known as the 'Crabtree effect', in cancer cells and possibly other cell types. The upstream pathways regulating this phenomenon are poorly understood. In diabetes, where glucose levels are elevated, the p90(RSK) (p90 ribosomal S6 kinase) has received much attention as a...

journal_title：Biochemical Society transactions

authors： Redman EK,Brookes PS,Karcz MK

更新日期：2013-02-01 00:00:00