Abstract:
:High glucose inhibits mitochondrial respiration, known as the 'Crabtree effect', in cancer cells and possibly other cell types. The upstream pathways regulating this phenomenon are poorly understood. In diabetes, where glucose levels are elevated, the p90(RSK) (p90 ribosomal S6 kinase) has received much attention as a potential upstream mediator of the effects of high glucose. Evidence is also emerging that p90(RSK) may play a role in cancer cell signalling, although the role of p90(RSK) in regulating cancer cell metabolism is unclear. In the present paper, we provide an overview of the Crabtree effect and its relationship to mitochondrial metabolism. Furthermore, preliminary data are presented suggesting a role for p90(RSK) and its upstream components, the ERK (extracellular-signal-regulated kinase) family of MAPKs (mitogen-activated protein kinases), in the Crabtree effect.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Redman EK,Brookes PS,Karcz MKdoi
10.1042/BST20120277subject
Has Abstractpub_date
2013-02-01 00:00:00pages
124-6issue
1eissn
0300-5127issn
1470-8752pii
BST20120277journal_volume
41pub_type
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