Role of reactive oxygen species in cell signalling pathways.

abstract：:Many Zn(II)2Cys6 transcriptional regulators exhibit changes in phosphorylation that are coincident with their roles in transcriptional activation. It is, however, unclear whether these changes occur as a cause of, or as a result of, transcriptional activation. In this paper, we explore the relationship between these t...

journal_title：Biochemical Society transactions

authors： Leverentz MK,Reece RJ

更新日期：2006-11-01 00:00:00

abstract：:The fission yeast septation initiation network, or SIN, is a signal transduction network that is required for septum formation in Schizosaccharomyces pombe. Its activity is tightly regulated through the cell cycle, to ensure proper co-ordination of mitosis and cytokinesis. SIN signalling requires three protein kinases...

journal_title：Biochemical Society transactions

authors： Krapp A,Simanis V

更新日期：2008-06-01 00:00:00

abstract：:Using the Edmonton protocol, a number of patients with Type 1 diabetes mellitus have remained insulin-independent for prolonged periods of time. In spite of this success, transplantation of islets from cadaver donors will remain a therapy for very few patients owing to a lack of donors. Thus, if cell therapy should be...

journal_title：Biochemical Society transactions

authors： Semb H

更新日期：2008-06-01 00:00:00

abstract：:Seeds of rape (Brassica napus L.) were germinated at various NaCl concentrations up to 200 mM. Germinating levels, seedling growth, triacylglycerol mobilization and lipase activity were investigated. High salt concentrations resulted in retardation of seed germination. Seedling growth as measured by radicle length was...

journal_title：Biochemical Society transactions

authors： Ben Miled DD,Zarrouk M,Chérif A

更新日期：2000-12-01 00:00:00

abstract：:Multiple alignments and phylogenetic tree constructions are established techniques for examining the evolutionary history of protease sequences in organisms such as humans, mice, fruitflies, nematode worms and yeast. They also facilitate the mapping of those conserved positions that are important for structure and cat...

journal_title：Biochemical Society transactions

authors： Southan C

更新日期：2007-06-01 00:00:00

abstract：:Anaphase B spindle elongation plays an important role in chromosome segregation. In the present paper, we discuss our model for anaphase B in Drosophila syncytial embryos, in which spindle elongation depends on an ip (interpolar) MT (microtubule) sliding filament mechanism generated by homotetrameric kinesin-5 motors ...

journal_title：Biochemical Society transactions

authors： Brust-Mascher I,Scholey JM

更新日期：2011-10-01 00:00:00

abstract：:Cardiac excitation-contraction coupling is initiated with the influx of Ca2+ ions across the plasma membrane through voltage-gated L-type calcium channels. This process is tightly regulated by modulation of the channel open probability and channel localization. Protein kinase A (PKA) is found in close association with...

journal_title：Biochemical Society transactions

authors： Pallien T,Klussmann E

更新日期：2020-02-28 00:00:00

abstract：:The collagens of vertebrates may be divided into three groups according to chain size and whether or not the helical domains are continuous. Present evidence suggests that, at least within one of these groups, similarity between collagens is reflected in the organization of the genes that encode them. Early evidence s...

journal_title：Biochemical Society transactions

authors： Dalgleish R

更新日期：1988-10-01 00:00:00

abstract：:We have identified two basic residues that are important for the recognition of secretin and vasoactive intestinal peptide (VIP) by their respective receptors. These two peptides containing an Asp residue at position 3 interacted with an arginine residue in transmembrane helix 2 (TM2) of the receptor, and the lysine r...

journal_title：Biochemical Society transactions

authors： Waelbroeck M,Perret J,Vertongen P,Van Craenenbroeck M,Robberecht P

更新日期：2002-08-01 00:00:00

abstract：:Brain development is a tightly controlled process that depends upon differentiation and function of neurons to allow for the formation of functional neural networks. Mutation of genes encoding structural proteins is well recognized as causal for neurodevelopmental disorders (NDDs). Recent studies have shown that aberr...

journal_title：Biochemical Society transactions

authors： Sartor F,Anderson J,McCaig C,Miedzybrodzka Z,Müller B

更新日期：2015-12-01 00:00:00

abstract：:Mutations in MYO7A (myosin VIIa) cause Usher syndrome type 1B, a disorder involving profound congenital deafness and progressive blindness. In the retina, most MYO7A is localized in the apical region of the RPE (retinal pigmented epithelial) cells, and a small amount is associated with the ciliary and periciliary memb...

journal_title：Biochemical Society transactions

authors： Williams DS,Lopes VS

更新日期：2011-10-01 00:00:00

abstract：:The transcript is populated with numerous overlapping codes that regulate all steps of gene expression. Deciphering these codes is very challenging due to the large number of variables involved, the non-modular nature of the codes, biases and limitations in current experimental approaches, our limited knowledge in gen...

journal_title：Biochemical Society transactions

authors： Bahiri-Elitzur S,Tuller T

更新日期：2020-08-28 00:00:00

abstract：:The overall effects of oestrogen on the vasculature are beneficial as a result of its antioxidant properties and ability to enhance relaxation by modulating synthesis of endothelium-derived vasodilators and smooth-muscle cell Ca2+ signalling. Although the protective effects of oestrogen are well accepted, only limited...

journal_title：Biochemical Society transactions

authors： Ruehlmann DO,Mann GE

更新日期：1997-02-01 00:00:00

abstract：:Our first experience of mannan-binding lectin (MBL)-replacement therapy was with a patient experiencing recurrent erythema multiforme associated with reactivation of herpes simplex virus; his erythematous eruptions could be controlled with infusions of fresh frozen plasma containing MBL, but not with plasma lacking MB...

journal_title：Biochemical Society transactions

authors： Valdimarsson H

更新日期：2003-08-01 00:00:00

abstract：:Glyoxalase I is part of the glyoxalase system present in the cytosol of cells. The glyoxalase system catalyses the conversion of reactive, acyclic alpha-oxoaldehydes into the corresponding alpha-hydroxyacids. Glyoxalase I catalyses the isomerization of the hemithioacetal, formed spontaneously from alpha-oxoaldehyde an...

journal_title：Biochemical Society transactions

authors： Thornalley PJ

更新日期：2003-12-01 00:00:00

abstract：:Many quinone-reactive enzyme complexes that are part of membrane-integral eukaryotic or prokaryotic respiratory electron transport chains contain one or more haem b molecules embedded in the membrane. In recent years, various novel proteins have emerged that are devoid of haem b but are thought to fulfil a similar fun...

journal_title：Biochemical Society transactions

authors： Simon J,Kern M

更新日期：2008-10-01 00:00:00

abstract：:PTB (polypyrimidine tract-binding protein) is a repressive regulator of alternative splicing. We have investigated the role of PTB in three model alternative splicing systems. In the alpha-actinin gene, PTB represses the SM (smooth muscle) exon by binding to key sites in the polypyrimidine tract. Repressive binding to...

journal_title：Biochemical Society transactions

authors： Spellman R,Rideau A,Matlin A,Gooding C,Robinson F,McGlincy N,Grellscheid SN,Southby J,Wollerton M,Smith CW

更新日期：2005-06-01 00:00:00

abstract：:The deposition of protein aggregates in various parts of our body gives rise to several devastating diseases, and the development of probes for the selective detection of aggregated proteins is crucial to advance our understanding of the pathogenesis underlying these diseases. LCPs (luminescent conjugated polythiophen...

journal_title：Biochemical Society transactions

authors： Klingstedt T,Nilsson KP

更新日期：2012-08-01 00:00:00

abstract：:Breast cancer heterogeneity demands that prognostic models must be biologically driven and recent clinical evidence indicates that future prognostic signatures need evaluation in the context of early compared with late metastatic risk prediction. In pre-clinical studies, we and others have shown that various protein-p...

journal_title：Biochemical Society transactions

authors： Weitsman G,Lawler K,Kelleher MT,Barrett JE,Barber PR,Shamil E,Festy F,Patel G,Fruhwirth GO,Huang L,Tullis ID,Woodman N,Ofo E,Ameer-Beg SM,Irshad S,Condeelis J,Gillett CE,Ellis PA,Vojnovic B,Coolen AC,Ng T

更新日期：2014-12-01 00:00:00

abstract：:In the amyloidogenic pathway, the APP (amyloid precursor protein) is proteolytically processed by the beta- and gamma-secretases to release the Abeta (amyloid-beta) peptide that is neurotoxic and aggregates in the brains of patients suffering from Alzheimer's disease. In the non-amyloidogenic pathway, APP is cleaved b...

journal_title：Biochemical Society transactions

authors： Hooper NM

更新日期：2005-04-01 00:00:00

abstract：:HDX-MS has emerged as a powerful tool to interrogate the structure and dynamics of proteins and their complexes. Recent advances in the methodology and instrumentation have enabled the application of HDX-MS to membrane proteins. Such targets are challenging to investigate with conventional strategies. Developing new t...

journal_title：Biochemical Society transactions

authors： Lau AM,Jia R,Bradshaw RT,Politis A

更新日期：2020-06-29 00:00:00

abstract：:Tandem repeats (TR) in proteins are common in nature and have several unique functions. They come in various forms that are frequently difficult to recognize from a sequence. A previously proposed structural classification has been recently implemented in the RepeatsDB database. This defines five main classes, mainly ...

journal_title：Biochemical Society transactions

authors： Paladin L,Tosatto SC

更新日期：2015-10-01 00:00:00

abstract：:MAPK (mitogen-activated protein kinase) signalling pathways contribute to the regulation of diverse responses, including normal and pathological aspects of cell growth, division, differentiation and death. Their ubiquity and versatility raise the issue of how they achieve specific coupling of signal with cellular resp...

journal_title：Biochemical Society transactions

authors： Bardwell L

更新日期：2006-11-01 00:00:00

abstract：:The ribosome translates the genetic information of an mRNA molecule into a sequence of amino acids. The ribosome utilizes tRNAs to connect elements of the RNA and protein worlds during protein synthesis, i.e. an anticodon as a unit of genetic information with the corresponding amino acid as a building unit of proteins...

journal_title：Biochemical Society transactions

authors： Márquez V,Wilson DN,Nierhaus KH

更新日期：2002-04-01 00:00:00

abstract：:Rapid interphase chromosome territory repositioning appears to function through the action of nuclear myosin and actin, in a nuclear motor complex. We have found that chromosome repositioning when cells leave the cell cycle is not apparent in cells that have mutant lamin A or that are lacking emerin. We discuss the po...

journal_title：Biochemical Society transactions

authors： Mehta IS,Elcock LS,Amira M,Kill IR,Bridger JM

更新日期：2008-12-01 00:00:00

abstract：:AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor trafficking is a fundamental mechanism for regulating synaptic strength, and hence may underlie cellular processes involved in learning and memory. PICK1 (protein that interacts with protein C-kinase) has recently emerged as a key regulator of AM...

journal_title：Biochemical Society transactions

authors： Hanley JG

更新日期：2006-11-01 00:00:00

abstract：:PTEN (phosphatase and tensin homologue deleted on chromosome 10) is an important tumour-suppressor gene that encodes a 3-phosphatase. The major substrate of PTEN is PIP(3) (phosphatidylinositol 3,4,5-trisphosphate) generated by the action of PI3Ks (phosphoinositide 3-kinases). Hereditary mutation of PTEN causes tumour...

journal_title：Biochemical Society transactions

authors： Suzuki A,Hamada K,Sasaki T,Mak TW,Nakano T

更新日期：2007-04-01 00:00:00

abstract：:PLUNC (palate, lung and nasal epithelium clone) proteins make up the largest branch of the BPI (bactericidal/permeability-increasing protein)/LBP (lipopolysaccharide-binding protein) family of lipid-transfer proteins. PLUNCs make up one of the most rapidly evolving mammalian protein families and exhibit low levels of ...

journal_title：Biochemical Society transactions

authors： Bingle CD,Bingle L,Craven CJ

更新日期：2011-08-01 00:00:00

abstract：:Inflammation or inflammatory cytokines and oxidative stress have often been associated, and thiol antioxidants, particularly glutathione, have often been seen as possible anti-inflammatory mediators. However, whereas several cytokine inhibitors have been approved for drug use in chronic inflammatory diseases, this has...

journal_title：Biochemical Society transactions

authors： Coppo L,Ghezzi P

更新日期：2011-10-01 00:00:00

abstract：:JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes implicated in tumorigenesis and neurodegenerative disorders. For example, genetic studies have demonstrated that the removal of specific Jnk genes can reduce neuronal death ass...

journal_title：Biochemical Society transactions

authors： Davies C,Tournier C

更新日期：2012-02-01 00:00:00