In vitro and in vivo effects of oxidative damage to deoxyguanosine.

abstract：:Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion. Pro- and anti-migratory effects of CD9 have been linked to adhesion-dependent signalling pathways, including phosphorylation of FAK (focal adhesion kinase) and activatio...

journal_title：Biochemical Society transactions

authors： Powner D,Kopp PM,Monkley SJ,Critchley DR,Berditchevski F

更新日期：2011-04-01 00:00:00

abstract：:HDX-MS has emerged as a powerful tool to interrogate the structure and dynamics of proteins and their complexes. Recent advances in the methodology and instrumentation have enabled the application of HDX-MS to membrane proteins. Such targets are challenging to investigate with conventional strategies. Developing new t...

journal_title：Biochemical Society transactions

authors： Lau AM,Jia R,Bradshaw RT,Politis A

更新日期：2020-06-29 00:00:00

abstract：:An important aspect of the cytochrome c electrochemistry is the possibility of coupling the 'heterogeneous reactions' with other redox enzymes. Cellobiose dehydrogenase, a 89170 Da glycoprotein that contains both FAD and a b-type haem as prosthetic groups, donates electrons to a number of acceptors, including cytochro...

journal_title：Biochemical Society transactions

authors： Fridman V,Wollenberger U,Bogdanovskaya V,Lisdat F,Ruzgas T,Lindgren A,Gorton L,Scheller FW

更新日期：2000-02-01 00:00:00

abstract：:In order for cells to divide in a proficient manner, they must first double their biomass, which is considered to be the main rate-limiting phase of cell proliferation. Cell growth requires an abundance of energy and biosynthetic precursors such as lipids and amino acids. Consequently, the energy and nutrient status o...

journal_title：Biochemical Society transactions

authors： Dunlop EA,Tee AR

更新日期：2013-08-01 00:00:00

abstract：:The Golgi complex (GC) has an essential role in the processing and sorting of proteins and lipids. The GC of mammalian cells is composed of stacks of cisternae connected by membranous tubules to create a continuous network, the Golgi ribbon, whose maintenance requires several core and accessory proteins. Despite this ...

journal_title：Biochemical Society transactions

authors： Ayala I,Mascanzoni F,Colanzi A

更新日期：2020-02-28 00:00:00

abstract：:Reactions involving removal and addition of glucose to N-glycans in the ER (endoplasmic reticulum) are performed in higher eukaryotes by glucosidases I and II and the UDP-glucose:glycoprotein glucosyltransferase respectively. Monoglucosylated N-glycan structures have been implicated in glycoprotein folding or ER quali...

journal_title：Biochemical Society transactions

authors： Jones D,Mehlert A,Ferguson MA

更新日期：2004-11-01 00:00:00

abstract：:A limited number of bacteria, yeast and fungi can convert hemicellulose or its monomers (xylose, arabinose, mannose and galactose) into ethanol with a satisfactory yield and productivity. In the present study we tested a number of thermophilic enrichment cultures, and new isolates of thermophilic anaerobic bacterial s...

journal_title：Biochemical Society transactions

authors： Sommer P,Georgieva T,Ahring BK

更新日期：2004-04-01 00:00:00

abstract：:A full picture of the similarities between Family A and Family B GPCRs (G-protein coupled receptors) has been frustrated by the lack of clear homology between the respective sequences. Here, we review previous computational studies on GPCR dimerization in which the putative dimerization interfaces have been analysed u...

journal_title：Biochemical Society transactions

authors： Vohra S,Chintapalli SV,Illingworth CJ,Reeves PJ,Mullineaux PM,Clark HS,Dean MK,Upton GJ,Reynolds CA

更新日期：2007-08-01 00:00:00

abstract：:Hsk1 (homologue of Cdc7 kinase 1) of the fission yeast is a member of the conserved Cdc7 (cell division cycle 7) kinase family, and promotes initiation of chromosome replication by phosphorylating Mcm (minichromosome maintenance) subunits, essential components for the replicative helicase. Recent studies, however, ind...

journal_title：Biochemical Society transactions

authors： Matsumoto S,Masai H

更新日期：2013-12-01 00:00:00

abstract：:The mTOR (mammalian target of rapamycin) signalling pathway functions as a nutrient sensor, both in individual cells and, more globally, in organs such as the fat body in Drosophila and the hypothalamus in the rat. The activity of placental amino acid transporters is decreased in IUGR (intrauterine growth restriction)...

journal_title：Biochemical Society transactions

authors： Roos S,Powell TL,Jansson T

更新日期：2009-02-01 00:00:00

abstract：:14-3-3 proteins are involved in signalling processes in neuronal cells. Using isoform-specific antibodies we have examined the variation in 14-3-3 isoform neurolocation in normal and scrapie-infected murine brain and show that in defined areas of the brain there are significant changes associated with the pathology of...

journal_title：Biochemical Society transactions

authors： Baxter HC,Fraser JR,Liu WG,Forster JL,Clokie S,Steinacker P,Otto M,Bahn E,Wiltfang J,Aitken A

更新日期：2002-08-01 00:00:00

abstract：:AMP-activated protein kinase (AMPK) is a regulator of cellular metabolism in response to changes in the energy status of the cells. AMPK was known to shut down energy-consuming pathways in response to a fall in the ATP/AMP ratio by phosphorylating key enzymes of intermediate metabolism. Here we will discuss the recent...

journal_title：Biochemical Society transactions

authors： Leclerc I,Viollet B,da Silva Xavier G,Kahn A,Rutter GA

更新日期：2002-04-01 00:00:00

abstract：:AWAP IV constitutes the C-terminal domain of the larger 81 kDa protein AWAK [Avian WAP (whey acidic protein) domain- and Kunitz domain-containing], which is predicted, through conserved domain database searching, to contain at least four WAP domains and one Kunitz domain. RT (reverse transcription)-PCR analyses reveal...

journal_title：Biochemical Society transactions

authors： Townes CL,Milona P,Hall J

更新日期：2006-04-01 00:00:00

abstract：:The vessel wall is a dynamic tissue that undergoes positive remodelling in response to altered mechanical stress. A typical example is vein graft remodelling, because veins do not develop arteriosclerosis until a vein segment is grafted on to arteries. In this process, it was observed that vascular endothelial and smo...

journal_title：Biochemical Society transactions

authors： Xu Q

更新日期：2007-11-01 00:00:00

abstract：:A comparative approach has been used to study the role of several lipid-body-binding proteins in plants and animals. Caleosins are a newly discovered class of calcium-binding lipid-body proteins found in plants and fungi, which we now report to have separate endoplasmic reticulum- and lipid-body-associated isoforms. W...

journal_title：Biochemical Society transactions

authors： Murphy DJ,Hernendez-Pinzon I,Patel K,Hope RG,McLauchlan J

更新日期：2000-12-01 00:00:00

abstract：:Endocytosis of transmembrane receptors largely occurs via clathrin-coated vesicles that bud from the plasma membrane and deliver their cargo to the endosomal system for recycling or degradation. PIs (phosphoinositides) control the timing and localization of endocytic membrane trafficking by recruiting adaptors and oth...

journal_title：Biochemical Society transactions

authors： Haucke V

更新日期：2005-12-01 00:00:00

abstract：:In the present article, I discuss recent developments in the naming of the TOR (target of rapamycin) protein. In particular, I address the issue of mammalian target of rapamycin (mTOR) versus the newer mechanistic target of rapamycin (MTOR). mTOR is the name given by the TOR community almost two decades ago and widely...

journal_title：Biochemical Society transactions

authors： Hall MN

更新日期：2013-08-01 00:00:00

abstract：:Oral and maxillofacial surgery is often challenging due to defective bone healing owing to the microbial environment of the oral cavity, the additional involvement of teeth and esthetic concerns. Insufficient bone volume as a consequence of aging and some oral and maxillofacial surgical procedures, such as tumor resec...

journal_title：Biochemical Society transactions

authors： Liu L,Chen Y,Song D,Huang D

更新日期：2020-06-30 00:00:00

abstract：:Approximately 30-50% of individuals who are allergic to natural rubber latex (NRL) show an associated hypersensitivity to some plant-derived foods, especially freshly consumed fruits. This association of latex allergy and allergy to plant-derived foods is called latex-fruit syndrome. An increasing number of plant sour...

journal_title：Biochemical Society transactions

authors： Wagner S,Breiteneder H

更新日期：2002-11-01 00:00:00

abstract：:AMPK (AMP-activated protein kinase) is a cellular energy sensor that monitors the ratio of AMP/ATP, and possibly also ADP/ATP, inside cells. Once activated by falling cellular energy levels, it acts to restore energy homoeostasis by switching on catabolic pathways that generate ATP, while switching off anabolic pathwa...

journal_title：Biochemical Society transactions

authors： Gowans GJ,Hardie DG

更新日期：2014-02-01 00:00:00

abstract：:The Drosophila melanogaster flightless I protein and its homologues in higher eukaryotes (FliI) are conserved members of the gelsolin family of actin-binding proteins. Members of the gelsolin family generally contain three or six copies of a 125-amino-acid residue gelsolin-related repeating unit, and may contain addit...

journal_title：Biochemical Society transactions

authors： Archer SK,Behm CA,Claudianos C,Campbell HD

更新日期：2004-12-01 00:00:00

abstract：:Seeds of rape (Brassica napus L.) were germinated at various NaCl concentrations up to 200 mM. Germinating levels, seedling growth, triacylglycerol mobilization and lipase activity were investigated. High salt concentrations resulted in retardation of seed germination. Seedling growth as measured by radicle length was...

journal_title：Biochemical Society transactions

authors： Ben Miled DD,Zarrouk M,Chérif A

更新日期：2000-12-01 00:00:00

abstract：:Collaborative communication lies at the centre of multicellular life. Gap junctions (GJs) are surface membrane structures that allow direct communication between cells. They were discovered in the 1960s following the convergence of the detection of low-resistance electrical interactions between cells and anatomical st...

journal_title：Biochemical Society transactions

authors： Evans WH

更新日期：2015-06-01 00:00:00

abstract：:Tandem repeats (TR) in proteins are common in nature and have several unique functions. They come in various forms that are frequently difficult to recognize from a sequence. A previously proposed structural classification has been recently implemented in the RepeatsDB database. This defines five main classes, mainly ...

journal_title：Biochemical Society transactions

authors： Paladin L,Tosatto SC

更新日期：2015-10-01 00:00:00

abstract：:FtsK is a multifunctional protein, which, in Escherichia coli, co-ordinates the essential functions of cell division, DNA unlinking and chromosome segregation. Its C-terminus is a DNA translocase, the fastest yet characterized, which acts as a septum-localized DNA pump. FtsK's C-terminus also interacts with the XerCD ...

journal_title：Biochemical Society transactions

authors： Grainge I

更新日期：2013-04-01 00:00:00

abstract：:CT responds to properties of PC-depleted membranes: increased negative charge density, which concentrates the enzyme at the membrane surface, and lipid packing perturbations, which create holes in the membrane surface into which the hydrophobic side chains of the amphipathic helix of domain M can intercalate. The PC-d...

journal_title：Biochemical Society transactions

authors： Cornell RB

更新日期：1998-08-01 00:00:00

abstract：:Large dense-core vesicles (LDCVs) were labelled in cultured bovine adrenal chromaffin cells expressing fluorescent chimaeric 'cargo' proteins that were targeted to these secretory vesicles. When the cells were stimulated with nicotine 48 h after transduction, the fractional loss of fluorescent LDCVs was much greater t...

journal_title：Biochemical Society transactions

authors： Wiegand UK,Duncan RR,Greaves J,Chow RH,Shipston MJ,Apps DK

更新日期：2003-08-01 00:00:00

abstract：:The past two decades in research has revealed the importance of leucine-rich repeat kinase 2 (LRRK2) in both monogenic and sporadic forms of Parkinson's disease (PD). In families, mutations in LRRK2 can cause PD with age-dependent but variable penetrance and genome-wide association studies have found variants of the g...

journal_title：Biochemical Society transactions

authors： Kluss JH,Mamais A,Cookson MR

更新日期：2019-04-30 00:00:00

abstract：:Although it is now well established that PI3K (phosphoinositide 3-kinase) is a key enzyme in several intracellular processes, there are still relatively few reports that precisely identify the specific isoforms of PI3K actually involved in such events. The lack of specific inhibitors has made it particularly difficult...

journal_title：Biochemical Society transactions

authors： Falasca M,Maffucci T

更新日期：2007-04-01 00:00:00

abstract：:Here, I review three new structural studies from our laboratory. First, the crystal structure of RNA polymerase (Pol) II in complex with an RNA inhibitor revealed that this RNA blocks transcription initiation by preventing DNA loading into the active-centre cleft. Secondly, the structure of the SRI (Set2 Rpb1-interact...

journal_title：Biochemical Society transactions

authors： Cramer P

更新日期：2006-12-01 00:00:00