Abstract:
:MAPK (mitogen-activated protein kinase) signalling pathways contribute to the regulation of diverse responses, including normal and pathological aspects of cell growth, division, differentiation and death. Their ubiquity and versatility raise the issue of how they achieve specific coupling of signal with cellular response. How do the kinases in the cascade distinguish their correct substrates from the vast excess of incorrect substrates? Furthermore, how do different signals elicit distinct responses when they are transmitted by the same components? This short review highlights several mechanisms that can promote specificity in MAPK signalling, including tethering interactions between MAPKs and their substrates and regulators mediated by docking sites, feedback loops and cross-pathway regulatory circuits, and the selective activation of scaffold proteins.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Bardwell Ldoi
10.1042/BST0340837subject
Has Abstractpub_date
2006-11-01 00:00:00pages
837-41issue
Pt 5eissn
0300-5127issn
1470-8752pii
BST0340837journal_volume
34pub_type
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