Abstract:
:Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-β (TGF-β) family signalling pathway. Similar to TGF-β, the complex roles of BMPs in development and disease are demonstrated by their dichotomous roles in various cancers and cancer stages. Although early studies implicated BMP signalling in tumour suppressive phenotypes, the results of more recent experiments recognize BMPs as potent tumour promoters. Many of these complexities are becoming illuminated by understanding the role of BMPs in their contextual role in unique cell types of cancer and the impact of their surrounding tumour microenvironment. Here we review the emerging roles of BMP signalling in cancer, with a focus on the molecular underpinnings of BMP signalling in individual cancers as a valid therapeutic target for cancer prevention and treatment.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Jiramongkolchai P,Owens P,Hong CCdoi
10.1042/BST20160069subject
Has Abstractpub_date
2016-08-15 00:00:00pages
1117-34issue
4eissn
0300-5127issn
1470-8752pii
BST20160069journal_volume
44pub_type
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