Abstract:
:We have investigated serum chemokines for their suitability as markers of atherosclerosis development in apoE (apolipoprotein E)-deficient ((-/-)) mice. Female C3H apoE(-/-) and C57BL apoE(-/-) mice were fed on either diet W (Western diet; 6 weeks) or normal rodent diet (12 weeks). Serum lipids (0, 6 and 12 weeks) and terminal chemokine levels were measured using commercially available assays, whereas the lesion area was determined using Oil-Red O-stained aortic sections. Serum lipids were higher in C3H apoE(-/-) mice for both diets throughout the study; however, lesions were significantly larger in C57BL apoE(-/-) mice fed on either diet. Chemokine levels were significantly lower in C3H apoE(-/-) mice fed on the normal diet, but no difference was observed between the two groups fed on diet W. We conclude that serum chemokine levels are potential markers for atherosclerosis susceptibility in C3H and C57BL apoE(-/-) mice fed on a normal rodent diet.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Parkin SL,Pritchett JP,Grimsditch DC,Bruckdorfer KR,Sahota PK,Lloyd A,Overend P,Benson GMdoi
10.1042/bst0320128keywords:
subject
Has Abstractpub_date
2004-02-01 00:00:00pages
128-30issue
Pt 1eissn
0300-5127issn
1470-8752journal_volume
32pub_type
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