Tyrosine kinase signaling in and on the endoplasmic reticulum.

Abstract:

:Tyrosine kinases are signaling molecules that are common to all metazoans and are involved in the regulation of many cellular processes such as proliferation and survival. While most attention has been devoted to tyrosine kinases signaling at the plasma membrane and the cytosol, very little attention has been dedicated to signaling at endomembranes. In this review, I will discuss recent evidence that we obtained on signaling of tyrosine kinases at the surface of the endoplasmic reticulum (ER), as well as in the lumen of this organelle. I will discuss how tyrosine kinase signaling might regulate ER proteostasis and the implication thereof to general cell physiology.

journal_name

Biochem Soc Trans

authors

Farhan H

doi

10.1042/BST20190543

subject

Has Abstract

pub_date

2020-02-28 00:00:00

pages

199-205

issue

1

eissn

0300-5127

issn

1470-8752

pii

222141

journal_volume

48

pub_type

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