Abstract:
:Tyrosine kinases are signaling molecules that are common to all metazoans and are involved in the regulation of many cellular processes such as proliferation and survival. While most attention has been devoted to tyrosine kinases signaling at the plasma membrane and the cytosol, very little attention has been dedicated to signaling at endomembranes. In this review, I will discuss recent evidence that we obtained on signaling of tyrosine kinases at the surface of the endoplasmic reticulum (ER), as well as in the lumen of this organelle. I will discuss how tyrosine kinase signaling might regulate ER proteostasis and the implication thereof to general cell physiology.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Farhan Hdoi
10.1042/BST20190543subject
Has Abstractpub_date
2020-02-28 00:00:00pages
199-205issue
1eissn
0300-5127issn
1470-8752pii
222141journal_volume
48pub_type
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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