Oestrogens and their promiscuous receptors: confronting reality.

Abstract:

:The binding sites of the oestrogen receptors alpha and beta have a structural requirement for ligands with two oxygen atoms (one of which is phenolic) spaced 11-12 A apart. They are open to many non-steroidal compounds, such as those from plants and the chemical industry. The importance of this interaction is the subject of current food safety research. This article examines the methods of assessment of oestrogenicity and their relationship to physiological events.

journal_name

Biochem Soc Trans

authors

Barnes S

doi

10.1042/0300-5127:0290231

keywords:

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

231-6

issue

Pt 2

eissn

0300-5127

issn

1470-8752

journal_volume

29

pub_type

杂志文章,评审
  • Reversibility of functional deficits in experimental models of Rett syndrome.

    abstract::Mutations in the X-linked MECP2 gene are the primary cause of the severe autism spectrum disorder RTT (Rett syndrome). Deletion of Mecp2 in mice recapitulates many of the overt neurological features seen in humans, and the delayed onset of symptoms is accompanied by deficits in neuronal morphology and synaptic physiol...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0380498

    authors: Cobb S,Guy J,Bird A

    更新日期:2010-04-01 00:00:00

  • The ProteinChip Biomarker System from Ciphergen Biosystems: a novel proteomics platform for rapid biomarker discovery and validation.

    abstract::Protein biochips are emerging in two distinct formats. The first involves high-density immobilized arrays of recognition molecules (e.g. antibodies), where target binding is monitored indirectly (e.g. via fluorescence). This technology is in its infancy, being limited by the availability of suitable binding molecules ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/

    authors: Chapman K

    更新日期:2002-04-01 00:00:00

  • Alkalithermophiles.

    abstract::Alkalithermophiles are an exciting subset of extremophilic organisms and represent extremophiles that are adapted to two extreme conditions, i.e. to a combination of alkaline and thermobiotic growth conditions. Among the anaerobic alkalithermophiles are representatives of both Bacteria and Archaea within a wide variet...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/bst0320193

    authors: Wiegel J,Kevbrin VV

    更新日期:2004-04-01 00:00:00

  • Multiple glucose 6-phosphate pools or channelling of flux in diverse pathways?

    abstract::Glucose 6-phosphate is an intermediate of pathways of glucose utilization and production as well as a regulator of enzyme activity and gene expression. Studies on the latter functions are in part based on measurement of the glucose 6-phosphate content in a whole-cell extract. Several studies have suggested that there ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/

    authors: Agius L,Centelles J,Cascante M

    更新日期:2002-04-01 00:00:00

  • Plant cell divisions: variations from the shortest symmetric path.

    abstract::In plants, the spatial arrangement of cells within tissues and organs is a direct consequence of the positioning of the new cell walls during cell division. Since the nineteenth century, scientists have proposed rules to explain the orientation of plant cell divisions. Most of these rules predict the new wall will fol...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20200529

    authors: Serra L,Robinson S

    更新日期:2020-12-18 00:00:00

  • Formate and its role in hydrogen production in Escherichia coli.

    abstract::The production of dihydrogen by Escherichia coli and other members of the Enterobacteriaceae is one of the classic features of mixed-acid fermentation. Synthesis of the multicomponent, membrane-associated FHL (formate hydrogenlyase) enzyme complex, which disproportionates formate into CO(2) and H(2), has an absolute r...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0330042

    authors: Sawers RG

    更新日期:2005-02-01 00:00:00

  • On conducting electron traffic across the periplasm.

    abstract::Dissimilatory metal-reducing bacteria are able to conduct electrons from their cytoplasmic membrane across the periplasm and the outer membrane to redox proteins located on the surface of their cells. The Mtr respiratory pathway in Shewanella is the best-understood metal-reducing pathway to date. The core components o...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20120129

    authors: Gralnick JA

    更新日期:2012-12-01 00:00:00

  • Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications.

    abstract::Resveratrol (3,4',5-trihydroxystilbene) is found in various plants, including grapes, berries and peanuts. It is also present in wines, especially red wines. During the last years, it has been the focus of numerous in vitro and in vivo studies investigating its biological attributes, which include mainly antioxidant a...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0351156

    authors: de la Lastra CA,Villegas I

    更新日期:2007-11-01 00:00:00

  • Peroxisomal ABC transporters: functions and mechanism.

    abstract::Peroxisomes are arguably the most biochemically versatile of all eukaryotic organelles. Their metabolic functions vary between different organisms, between different tissue types of the same organism and even between different developmental stages or in response to changed environmental conditions. New functions for p...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20150127

    authors: Baker A,Carrier DJ,Schaedler T,Waterham HR,van Roermund CW,Theodoulou FL

    更新日期:2015-10-01 00:00:00

  • Cellular consequences of inositol depletion.

    abstract::The inositol-depletion hypothesis was suggested to explain the therapeutic mechanism of mood-stabilizing drugs. Focus was previously on the phosphatidylinositol signalling pathway and on the regulatory roles of Ins(3,4,5)P(3) and DAG (diacylglycerol). Recent findings indicate that inositol and inositol-containing mole...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0371099

    authors: Deranieh RM,Greenberg ML

    更新日期:2009-10-01 00:00:00

  • Electrical consequences of cardiac myocyte: fibroblast coupling.

    abstract::Gap junctions are channels which allow electrical signals to propagate through the heart from the sinoatrial node and through the atria, conduction system and onwards to the ventricles, and hence are essential for co-ordinated cardiac contraction. Twelve connexin (Cx) proteins make up one gap junction channel, of whic...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20150035

    authors: McArthur L,Chilton L,Smith GL,Nicklin SA

    更新日期:2015-06-01 00:00:00

  • Biochemistry and functional significance of collagen cross-linking.

    abstract::The biophysical characteristics of vascular tissues are dependent largely on the properties of fibrillar collagens. Considering the predominant structural component, collagen type I, the present review describes the mechanisms of formation and maturation of lysyl oxidase-mediated cross-linking, leading to an understan...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0350849

    authors: Robins SP

    更新日期:2007-11-01 00:00:00

  • The quest for Factor VIIa exosite inhibitors.

    abstract::Coagulation proteases are involved in a highly orchestrated proteolytic cascade which is essential for haemostasis and blood clotting. In particular, the initiator of the coagulation cascade, Factor VIIa, binds to its cofactor, tissue factor, and its substrate, Factor X, via exosite interactions to form a ternary cata...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0350555

    authors: Amour A,Hutchinson J,Ruiz Avendaño AM,Ratcliffe S,Alvarez E,Martin J,Toomey JR,Senger S,Wolfendale M,Mooney C

    更新日期:2007-06-01 00:00:00

  • Engineering therapeutic antibodies for improved function.

    abstract::The binding sites on human IgG1 for human Fc gamma receptor (Fc gamma R) I, Fc gamma RIIa, Fc gamma RIIb, Fc gamma RIIIa and neonatal FcR have been mapped. A common set of IgG1 residues is involved in binding to all Fc gamma Rs, while Fc gamma RII and Fc gamma RIII utilize distinct sites outside this common set. In ad...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0300487

    authors: Presta LG,Shields RL,Namenuk AK,Hong K,Meng YG

    更新日期:2002-08-01 00:00:00

  • Glycative stress and glyoxalase in kidney disease and aging.

    abstract::Glycation is one of the important reactions regulating physiological state, and glycative stress, namely an overwhelming and unfavourable glycation state, is established as a pathological factor. Glycative stress is closely associated with not only various kidney diseases, but also kidney aging. Accumulating evidence,...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20140007

    authors: Inagi R

    更新日期:2014-04-01 00:00:00

  • Dissecting DISC1 function through protein-protein interactions.

    abstract::Disrupted in schizophrenia 1 (DISC1) is emerging in the eyes of many as the most promising candidate of all the schizophrenia risk genes. This viewpoint is derived from the combination of genetic, clinical, imaging and rapidly advancing cell biology data around this gene. All of these areas have been reviewed extensiv...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0351283

    authors: Brandon NJ

    更新日期:2007-11-01 00:00:00

  • Study of prostaglandin receptors in mitochondria on apoptosis of human lung carcinoma cell line A549.

    abstract::PGs (prostaglandins) are synthesized through the cyclo-oxygenase (COX-1 and -2) pathway in a variety of cells in response to various physiological stimuli. All cells require at least one pathway for apoptosis, and mitochondrial play a central role in regulation of apoptosis. In a previous study, incubation of A549 cel...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0321078

    authors: Fang KM,Shu WH,Chang HC,Wang JJ,Mak OT

    更新日期:2004-12-01 00:00:00

  • Pathophysiology, pleiotrophy and paradigm shifts: genetic lessons from Parkinson's disease.

    abstract::PD (Parkinson's disease) is an aetiologically heterogeneous disorder characterized by a clinical phenotype consisting of resting tremor, rigidity and bradykinesia. Motor symptoms are associated with a progressive loss of dopaminergic neurons, with Lewy body inclusions within surviving neurons. Although heritability st...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0330586

    authors: Ross OA,Farrer MJ

    更新日期:2005-08-01 00:00:00

  • Probing cytoplasmic organization and the actin cytoskeleton of plant cells with optical tweezers.

    abstract::In interphase plant cells, the actin cytoskeleton is essential for intracellular transport and organization. To fully understand how the actin cytoskeleton functions as the structural basis for cytoplasmic organization, both molecular and physical aspects of the actin organization have to be considered. In the present...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0380823

    authors: Ketelaar T,van der Honing HS,Emons AM

    更新日期:2010-06-01 00:00:00

  • Characterization of AWAP IV, the C-terminal domain of the avian protein AWAK.

    abstract::AWAP IV constitutes the C-terminal domain of the larger 81 kDa protein AWAK [Avian WAP (whey acidic protein) domain- and Kunitz domain-containing], which is predicted, through conserved domain database searching, to contain at least four WAP domains and one Kunitz domain. RT (reverse transcription)-PCR analyses reveal...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20060267

    authors: Townes CL,Milona P,Hall J

    更新日期:2006-04-01 00:00:00

  • DNA replication in the hyperthermophilic archaeon Sulfolobus solfataricus.

    abstract::Studies of the DNA-replication machinery of Archaea have revealed striking similarities to that of eukaryotes. Indeed, it appears that in most cases Archaea possess a simplified version of the eukaryotic replication apparatus. Studies of Archaea are therefore shedding light on the fundamental processes of DNA replicat...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0310674

    authors: Dionne I,Robinson NP,McGeoch AT,Marsh VL,Reddish A,Bell SD

    更新日期:2003-06-01 00:00:00

  • Probing the druggability of protein-protein interactions: targeting the Notch1 receptor ankyrin domain using a fragment-based approach.

    abstract::In order to achieve greater selectivity in drug discovery, researchers in both academia and industry are targeting cell regulatory systems. This often involves targeting the protein-protein interactions of regulatory multiprotein assemblies. Protein-protein interfaces are widely recognized to be challenging targets as...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0391327

    authors: Abdel-Rahman N,Martinez-Arias A,Blundell TL

    更新日期:2011-10-01 00:00:00

  • Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes.

    abstract::Accumulating evidence indicates that beta-cells die by apoptosis in T1DM (Type 1 diabetes mellitus). Apoptosis is an active gene-directed process, and recent observations suggest that beta-cell apoptosis depends on the parallel and/or sequential up- and down-regulation of hundreds of genes controlled by key transcript...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0360321

    authors: Eizirik DL,Moore F,Flamez D,Ortis F

    更新日期:2008-06-01 00:00:00

  • Mitotic motors and chromosome segregation: the mechanism of anaphase B.

    abstract::Anaphase B spindle elongation plays an important role in chromosome segregation. In the present paper, we discuss our model for anaphase B in Drosophila syncytial embryos, in which spindle elongation depends on an ip (interpolar) MT (microtubule) sliding filament mechanism generated by homotetrameric kinesin-5 motors ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0391149

    authors: Brust-Mascher I,Scholey JM

    更新日期:2011-10-01 00:00:00

  • The zDHHC family of S-acyltransferases.

    abstract::The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated protein...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20140270

    authors: Lemonidis K,Werno MW,Greaves J,Diez-Ardanuy C,Sanchez-Perez MC,Salaun C,Thomson DM,Chamberlain LH

    更新日期:2015-04-01 00:00:00

  • Metabolic regulation of nitrogen fixation in Rhodospirillum rubrum.

    abstract::Nitrogenase activity in Rhodospirillum rubrum is post-translationally regulated by DRAG (dinitrogenase reductase glycohydrolase) and DRAT (dinitrogenase reductase ADP-ribosylation transferase). When a sudden increase in fixed nitrogen concentration or energy depletion is sensed by the cells, DRAG is inactivated and DR...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0340160

    authors: Wang H,Norén A

    更新日期:2006-02-01 00:00:00

  • VEGF signalling: integration and multi-tasking in endothelial cell biology.

    abstract::The central role of VEGF (vascular endothelial growth factor A) in angiogenesis is dependent upon its ability to co-ordinately regulate multiple endothelial functions. The multifunctionality of VEGF at the cellular level results from its ability to initiate a diverse, complex and integrated network of signalling pathw...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0311171

    authors: Zachary I

    更新日期:2003-12-01 00:00:00

  • The role of Trim25 in development, disease and RNA metabolism.

    abstract::Trim25 is a member of the tripartite motif family of E3 ubiquitin ligases. It plays major roles in innate immunity and defence against viral infection, control of cell proliferation and migration of cancer cells. Recent work identified Trim25 as being able to bind to RNA and to regulate Lin28a-mediated uridylation of ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20160077

    authors: Heikel G,Choudhury NR,Michlewski G

    更新日期:2016-08-15 00:00:00

  • Floral stem cells: from dynamic balance towards termination.

    abstract::During early flower development in Arabidopsis, floral stem cells proliferate and produce a sufficient amount of cells that are recruited for organogenesis. However, after the central organ primordia initiate, stem cell activity in the floral meristem is terminated to ensure the differentiation of a fixed number of fl...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0380613

    authors: Sun B,Ito T

    更新日期:2010-04-01 00:00:00

  • New insights into the plasticity of the endothelial phenotype.

    abstract::The mammalian vascular system consists of two distinct, but closely related, networks: the blood vasculature (itself divided into arterial and venous networks) and the lymphatic vasculature. EC (endothelial cell) lineage specification has been proposed to be determined during embryonic development, after which the ECs...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20110723

    authors: Cooley LS,Edwards DR

    更新日期:2011-12-01 00:00:00