Control of growth factor receptor dynamics by reversible ubiquitination.

Abstract:

:Activated tyrosine kinase receptors acquire ubiquitin tags. Ubiquitination governs receptor down-regulation through interaction with components of the endosomal ESCRT (endosomal sorting complexes required for transport) machinery that shepherds receptors into luminal vesicles of multivesicular bodies en route to the lysosome. We have characterized two de-ubiquitinating enzymes that interact with components of this machinery. AMSH [associated molecule with the SH3 domain (Src homology 3 domain) of STAM (signal transducing adapter molecule)] shows specificity for Lys63- over Lys48-linked ubiquitin and may act to rescue receptors from taking the lysosomal pathway. In contrast, UBPY (ubiquitin-specific processing protease Y) does not discriminate between Lys48 and Lys63-linked chains and is required for lysosomal sorting.

journal_name

Biochem Soc Trans

authors

Urbé S,McCullough J,Row P,Prior IA,Welchman R,Clague MJ

doi

10.1042/BST0340754

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

754-6

issue

Pt 5

eissn

0300-5127

issn

1470-8752

pii

BST0340754

journal_volume

34

pub_type

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