Abstract:
:After the discovery of leucine-rich repeat kinase 2 (LRRK2) as a risk factor for sporadic Parkinson's disease (PD) and mutations in LRRK2 as a cause of some forms of familial PD, there has been substantial interest in finding chemical modulators of LRRK2 function. Most of the pathogenic mutations in LRRK2 are within the enzymatic cores of the protein; therefore, many screens have focused on finding chemical modulators of this enzymatic activity. There are alternative screening approaches that could be taken to investigate compounds that modulate LRRK2 cellular functions. These screens are more often phenotypic screens. The preparation for a screen has to be rigorous and enable high-throughput accurate assessment of a compound's activity. The pipeline to beginning a drug screen and some LRRK2 inhibitor and phenotypic screens will be discussed.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Mortiboys Hdoi
10.1042/BST20160242subject
Has Abstractpub_date
2016-12-15 00:00:00pages
1617-1623issue
6eissn
0300-5127issn
1470-8752pii
BST20160242journal_volume
44pub_type
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