Abstract:
:The regulation of macrophage cholesterol homoeostasis is of crucial importance in the pathogenesis of atherosclerosis, an underlying cause of heart attack and stroke. Several recent studies have revealed a critical role for the cytokine TGF-beta (transforming growth factor-beta), a key regulator of the immune and inflammatory responses, in atherogenesis. We discuss here the TGF-beta signalling pathway and its role in this disease along with the outcome of our recent studies on the action of the cytokine on the expression of key genes implicated in the uptake or efflux of cholesterol by macrophages and the molecular mechanisms underlying such regulation.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Ramji DP,Singh NN,Foka P,Irvine SA,Arnaoutakis Kdoi
10.1042/BST0341141subject
Has Abstractpub_date
2006-12-01 00:00:00pages
1141-4issue
Pt 6eissn
0300-5127issn
1470-8752pii
BST0341141journal_volume
34pub_type
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