Abstract:
:The evolution of proteins is inseparably linked to their function. Because most biological processes involve a number of different proteins, it may become impossible to study the evolutionary properties of proteins in isolation. In the present article, we show how simple mechanistic models of biological processes can complement conventional comparative analyses of biological traits. We use the specific example of the phage-shock stress response, which has been well characterized in Escherichia coli, to elucidate patterns of gene sharing and sequence conservation across bacterial species.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Huvet M,Toni T,Tan H,Jovanovic G,Engl C,Buck M,Stumpf MPdoi
10.1042/BST0370762subject
Has Abstractpub_date
2009-08-01 00:00:00pages
762-7issue
Pt 4eissn
0300-5127issn
1470-8752pii
BST0370762journal_volume
37pub_type
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