Abstract:
:Glycosaminoglycans (GAGs), present in the extracellular matrix, are exploited by numerous, distinct microbes for cellular attachment, adhesion, invasion and evasion of the host immune system. Glycosaminoglycans, including the widely used, clinical anticoagulant heparin and semi-synthetic analogues thereof, have been reported to inhibit and disrupt interactions between microbial proteins and carbohydrates present on the surface of host cells. However, the anticoagulant properties of unmodified, pharmaceutical heparin preparations preclude their capabilities as therapeutics for infectious disease states. Here, unique Glycosaminoglycan-like saccharides from various, distinct marine species are reported for their potential use as therapeutics against infectious diseases; many of which possess highly attenuated anticoagulant activities, while retaining significant antimicrobial properties.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Mycroft-West CJ,Yates EA,Skidmore MAdoi
10.1042/BST20170404subject
Has Abstractpub_date
2018-08-20 00:00:00pages
919-929issue
4eissn
0300-5127issn
1470-8752pii
BST20170404journal_volume
46pub_type
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