Chaperone-assisted assembly of the proteasome core particle.

abstract：:Assembly of ribonucleoprotein complexes is a facilitated quality-controlled process that typically includes modification to the RNA component from precursor to mature form. The SRP (signal recognition particle) is a cytosolic ribonucleoprotein that catalyses protein targeting to the endoplasmic reticulum. Assembly of ...

journal_title：Biochemical Society transactions

authors： Leung E,Brown JD

更新日期：2010-08-01 00:00:00

abstract：:The transcript is populated with numerous overlapping codes that regulate all steps of gene expression. Deciphering these codes is very challenging due to the large number of variables involved, the non-modular nature of the codes, biases and limitations in current experimental approaches, our limited knowledge in gen...

journal_title：Biochemical Society transactions

authors： Bahiri-Elitzur S,Tuller T

更新日期：2020-08-28 00:00:00

abstract：:Three mammalian expression systems suitable for expressing recombinant receptors have been described. Each is suited to a different aspect of the study of receptors and their behaviour. IRES-based vectors are ideal for creating stable mammalian cell lines suitable for screening receptors using a signalling readout. Un...

journal_title：Biochemical Society transactions

authors： Rhodes AD,Bevan N,Patel K,Lee M,Rees S

更新日期：1998-11-01 00:00:00

abstract：:Escherichia coli FtsK is a septum-located DNA translocase that co-ordinates the late stages of cytokinesis and chromosome segregation. Relatives of FtsK are present in most bacteria; in Bacillus subtilis, the FtsK orthologue, SpoIIIE, transfers the majority of a chromosome into the forespore during sporulation. DNA tr...

journal_title：Biochemical Society transactions

authors： Sherratt DJ,Arciszewska LK,Crozat E,Graham JE,Grainge I

更新日期：2010-04-01 00:00:00

abstract：:Using the Edmonton protocol, a number of patients with Type 1 diabetes mellitus have remained insulin-independent for prolonged periods of time. In spite of this success, transplantation of islets from cadaver donors will remain a therapy for very few patients owing to a lack of donors. Thus, if cell therapy should be...

journal_title：Biochemical Society transactions

authors： Semb H

更新日期：2008-06-01 00:00:00

abstract：:Experimental processes in the life sciences are becoming increasingly complex. As a result, recording, archiving and sharing descriptions of these processes and of the results of experiments is becoming ever more challenging. However, validation of results, sharing of best practice and integrated analysis all require ...

journal_title：Biochemical Society transactions

authors： Paton NW

更新日期：2008-02-01 00:00:00

abstract：:PilZ domain-containing proteins constitute a large family of bacterial signaling proteins. As a widely distributed protein domain for the binding of the second messenger c-di-GMP, the canonical PilZ domain contains a set of motifs that define the binding site for c-di-GMP and an allosteric switch for propagating local...

journal_title：Biochemical Society transactions

authors： Cheang QW,Xin L,Chea RYF,Liang ZX

更新日期：2019-02-28 00:00:00

abstract：:Bacterial cellular metabolism is renowned for its metabolic diversity and adaptability. However, certain environments present particular challenges. Aerobic metabolism of highly reduced carbon substrates by soil bacteria such as Paracoccus pantotrophus presents one such challenge since it may result in excessive elect...

journal_title：Biochemical Society transactions

authors： Gates AJ,Butler CS,Richardson DJ,Butt JN

更新日期：2011-01-01 00:00:00

abstract：:The serum- and glucocorticoid-inducible kinase SGK1 is an ubiquitously expressed kinase with the ability to regulate a variety of transport systems. Recent observations point to a role of SGK1 in the regulation of diverse physiological functions such as epithelial transport and cardiac and neuronal excitability. At le...

journal_title：Biochemical Society transactions

authors： Lang F,Vallon V,Grahammer F,Palmada M,Böhmer C

更新日期：2005-02-01 00:00:00

abstract：:The oxidoreductase Trx-1 (thioredoxin 1) is highly conserved and found intra- and extra-cellularly in mammalian systems. There is increasing interest in its capacity to regulate immune function based on observations of altered distribution and expression during ageing and disease. We have investigated previously wheth...

journal_title：Biochemical Society transactions

authors： Griffiths HR,Bennett SJ,Olofsson P,Dunston CR

更新日期：2014-08-01 00:00:00

abstract：:Single-molecule fluorescence methods, particularly single-molecule FRET (fluorescence resonance energy transfer), have provided novel insights into the structure, interactions and dynamics of biological systems. ALEX (alternating-laser excitation) spectroscopy is a new method that extends single-molecule FRET by provi...

journal_title：Biochemical Society transactions

authors： Santoso Y,Hwang LC,Le Reste L,Kapanidis AN

更新日期：2008-08-01 00:00:00

abstract：:Malaria during pregnancy is caused when parasite-infected erythrocytes accumulate within the placenta through interactions between the VAR2CSA protein on the infected erythrocyte surface and placental CSPGs (chondroitin sulfate proteoglycans). This interaction is the major target for therapeutics to treat or prevent p...

journal_title：Biochemical Society transactions

authors： Khunrae P,Higgins MK

更新日期：2010-10-01 00:00:00

abstract：:The Wilms' tumour-suppressor gene (WT1), encodes a zinc-finger transcription factor that is critical for the development of several organs, including the kidneys, gonads and spleen. Despite its identification as a tumour suppressor that plays a crucial role in the formation of a paediatric malignancy of the kidneys (W...

journal_title：Biochemical Society transactions

authors： Hartkamp J,Roberts SG

更新日期：2008-08-01 00:00:00

abstract：:Complex biological machines arise from self-assembly on the basis of structural features programmed into sequence-specific macromolecules (i.e. polypeptides and polynucleotides) at the molecular level. As a consequence of the near-absolute control of macromolecular architecture that results from such sequence specific...

journal_title：Biochemical Society transactions

authors： Dublin S,Zimenkov Y,Conticello VP

更新日期：2009-08-01 00:00:00

abstract：:Sister-chromatid cohesion, thought to be primarily mediated by the cohesin complex, is essential for chromosome segregation. The forces holding the two sisters resist the tendency of microtubules to prematurely pull sister DNAs apart and thereby prevent random segregation of the genome during mitosis, and consequent a...

journal_title：Biochemical Society transactions

authors： Oliveira RA,Nasmyth K

更新日期：2010-12-01 00:00:00

abstract：:The mTOR (mammalian target of rapamycin) signalling pathway functions as a nutrient sensor, both in individual cells and, more globally, in organs such as the fat body in Drosophila and the hypothalamus in the rat. The activity of placental amino acid transporters is decreased in IUGR (intrauterine growth restriction)...

journal_title：Biochemical Society transactions

authors： Roos S,Powell TL,Jansson T

更新日期：2009-02-01 00:00:00

abstract：:The statins are inhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase (HMG-CoAR), and are utilized to decrease levels of atherogenic lipoproteins in patients with, or who are at high risk of, cardiovascular disease. This study describes the inhibition of a recombinant, catalytic fragment of human HMG-CoAR b...

journal_title：Biochemical Society transactions

authors： Holdgate GA,Ward WH,McTaggart F

更新日期：2003-06-01 00:00:00

abstract：:We have identified three groups of growth-constraint genes using mosaic genetic screens in Drosophila melanogaster, including PTEN (phosphatase and tensin homologue deleted on chromosome 10), and the tuberous sclerosis complex (TSC) genes, Tsc1 and Tsc2. Our studies show that all three groups of genes participate in m...

journal_title：Biochemical Society transactions

authors： Potter CJ,Pedraza LG,Huang H,Xu T

更新日期：2003-06-01 00:00:00

abstract：:The metabolism in vitro of [1-(14)C]linoleate, [1-(14)C]linolenate and their 9(S)-hydroperoxides in tulip (Tulipa gesneriana) was found to be under the control of 9-lipoxygenase and allene oxide synthase, and directed towards alpha-ketol, gamma-ketol and the novel compound (12Z)-10-oxo-11-hydroxy-12-octadecadienoic ac...

journal_title：Biochemical Society transactions

authors： Grechkin AN,Mukhtarova LS,Hamberg M

更新日期：2000-12-01 00:00:00

abstract：:Colicins are protein antibiotics produced by Escherichia coli to kill closely related non-identical competing species. They have taken advantage of the promiscuity of several proteins in the cell envelope for entry into the bacterial cell. The Tol-Pal system comprises one such ensemble of periplasmic and membrane-asso...

journal_title：Biochemical Society transactions

authors： Penfold CN,Li C,Zhang Y,Vankemmelbeke M,James R

更新日期：2012-12-01 00:00:00

abstract：:Mutations activating the PI3K (phosphoinositide 3-kinase)/Akt signalling pathway and inactivating the TP53 tumour-suppressor gene are common mechanisms that cancer cells require to proliferate and escape pre-programmed cell death. In a well-described mechanism, Akt mediates negative control of p53 levels through enhan...

journal_title：Biochemical Society transactions

authors： Abraham AG,O'Neill E

更新日期：2014-08-01 00:00:00

abstract：:Tyrosine kinases are signaling molecules that are common to all metazoans and are involved in the regulation of many cellular processes such as proliferation and survival. While most attention has been devoted to tyrosine kinases signaling at the plasma membrane and the cytosol, very little attention has been dedicate...

journal_title：Biochemical Society transactions

authors： Farhan H

更新日期：2020-02-28 00:00:00

abstract：:Neutrophils are very abundant, short-lived leucocytes and their death by apoptosis is central to homoeostasis and the resolution of inflammation, yet the trigger for apoptosis is still a topic of debate. Depolarization of the mitochondrial membrane has been supposed to initiate neutrophil spontaneous apoptosis, as neu...

journal_title：Biochemical Society transactions

authors： Scheel-Toellner D,Wang KQ,Webb PR,Wong SH,Craddock R,Assi LK,Salmon M,Lord JM

更新日期：2004-06-01 00:00:00

abstract：:Changes in mitochondrial superoxide and hydrogen peroxide production may contribute to various pathologies, and even aging, given that over time and in certain conditions, they damage macromolecules and disrupt normal redox signalling. Mitochondria-targeted antioxidants such as mitoQ, mitoVitE, and mitoTEMPO have open...

journal_title：Biochemical Society transactions

authors： Watson MA,Wong HS,Brand MD

更新日期：2019-10-31 00:00:00

abstract：:The past two decades in research has revealed the importance of leucine-rich repeat kinase 2 (LRRK2) in both monogenic and sporadic forms of Parkinson's disease (PD). In families, mutations in LRRK2 can cause PD with age-dependent but variable penetrance and genome-wide association studies have found variants of the g...

journal_title：Biochemical Society transactions

authors： Kluss JH,Mamais A,Cookson MR

更新日期：2019-04-30 00:00:00

abstract：:The vessel wall is a dynamic tissue that undergoes positive remodelling in response to altered mechanical stress. A typical example is vein graft remodelling, because veins do not develop arteriosclerosis until a vein segment is grafted on to arteries. In this process, it was observed that vascular endothelial and smo...

journal_title：Biochemical Society transactions

authors： Xu Q

更新日期：2007-11-01 00:00:00

abstract：:Microvilli are found on the apical surface of epithelial cells. Recent studies on the microvillar proteins ezrin and EBP50 (ezrin/radixin/moesin-binding phosphoprotein of 50 kDa) have revealed both the dynamics and the regulation of microvillar components, and how a dynamic ezrin phosphocycle is necessary to confine m...

journal_title：Biochemical Society transactions

authors： Viswanatha R,Bretscher A,Garbett D

更新日期：2014-02-01 00:00:00

abstract：:The advantages of Hansenula polymorpha as a new yeast expression system are discussed in terms of the powerful and regulatable methanol oxidase promoter and the organism's ability to grow on cheap carbon sources. The development of techniques for conventional genetic analysis is described. A total of 218 mutants have ...

journal_title：Biochemical Society transactions

authors： Sudbery PE,Gleeson MA,Veale RA,Ledeboer AM,Zoetmulder MC

更新日期：1988-12-01 00:00:00

abstract：:Much work has gone into understanding the physical basis of the enormous catalytic power of enzymes over the last 50 years or so. Nevertheless, the detailed mechanism used by Nature's catalysts to speed chemical transformations remains elusive. DHFR (dihydrofolate reductase) has served as a paradigm to study the relat...

journal_title：Biochemical Society transactions

authors： Allemann RK,Evans RM,Loveridge EJ

更新日期：2009-04-01 00:00:00

abstract：:Signalling by pattern recognition receptors (PRRs) is critical for protecting the host against pathogens. Disruption of these signalling pathways has been implicated in many diseases ranging from infection susceptibility to cancer and autoimmune disease. Understanding how PRRs signal is of critical importance due to t...

journal_title：Biochemical Society transactions

authors： Macleod C,Bryant CE

更新日期：2017-10-15 00:00:00