Post-transcriptional regulation of gene expression by Unr.

Abstract:

:Unr (upstream of N-ras) is a eukaryotic RNA-binding protein that has a number of roles in the post-transcriptional regulation of gene expression. Originally identified as an activator of internal initiation of picornavirus translation, it has since been shown to act as an activator and inhibitor of cellular translation and as a positive and negative regulator of mRNA stability, regulating cellular processes such as mitosis and apoptosis. The different post-transcriptional functions of Unr depend on the identity of its mRNA and protein partners and can vary with cell type and changing cellular conditions. Recent high-throughput analyses of RNA-protein interactions indicate that Unr binds to a large subset of cellular mRNAs, suggesting that Unr may play a wider role in translational responses to cellular signals than previously thought.

journal_name

Biochem Soc Trans

authors

Ray S,Catnaigh PÓ,Anderson EC

doi

10.1042/BST20140271

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

323-7

issue

3

eissn

0300-5127

issn

1470-8752

pii

BST20140271

journal_volume

43

pub_type

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