Interactions between Epac1 and ezrin in the control of endothelial barrier function.

Abstract:

:Loss of barrier function in the vasculature promotes inflammatory signalling which in turn contributes to the progression of cardiovascular disease. cAMP can protect against endothelial dysfunction through the effectors PKA (protein kinase A) and Epac (exchange protein directly activated by cAMP). The present review outlines the role of Epac1 signalling within the endothelium and, in particular, the role of Epac1 in cytoskeletal dynamics and the control of cell morphology. The actin/cytoskeleton linker ezrin will be described in terms of the growing body of evidence placing it downstream of cAMP signalling as a mediator of altered cellular morphology.

journal_name

Biochem Soc Trans

authors

Parnell E,Yarwood SJ

doi

10.1042/BST20130271

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

274-8

issue

2

eissn

0300-5127

issn

1470-8752

pii

BST20130271

journal_volume

42

pub_type

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