Abstract:
:The n-6 polyunsaturated fatty acid, arachidonic acid, is a precursor of prostaglandins, leukotrienes and related compounds that have important roles as mediators and regulators of inflammation. Consuming increased amounts of long chain n-3 polyunsaturated fatty acids (found in oily fish and fish oils) results in a partial replacement of the arachidonic acid in cell membranes by eicosapentaenoic and docosahexaenoic acids. This leads to decreased production of arachidonic acid-derived mediators. This alone is a potentially beneficial anti-inflammatory effect of n-3 fatty acids. However, n-3 fatty acids have a number of other effects that might occur downstream of altered eicosanoid production or are independent of this. For example, they result in suppressed production of pro-inflammatory cytokines and can modulate adhesion molecule expression. These effects occur at the level of altered gene expression.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Calder PCdoi
10.1042/BST0330423keywords:
subject
Has Abstractpub_date
2005-04-01 00:00:00pages
423-7issue
Pt 2eissn
0300-5127issn
1470-8752pii
BST0330423journal_volume
33pub_type
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