Abstract:
:The PI3K (phosphoinositide 3-kinase) family of lipid kinases regulate cell motility in diverse organisms and cell types. In mammals, the main PI3K enzyme activated by chemokine receptor signalling is the class IB isoform, p110gamma. Studies of p110gamma-knockout mice have shown an essential function for this isoform in chemotaxis of neutrophils and macrophages both in vitro and in vivo. However, the roles of p110gamma and other PI3K enzymes and regulatory subunits in lymphocyte motility have been more difficult to discern. Recent studies of adoptively transferred, fluorescently labelled lymphocytes have revealed complex and unexpected functions for PI3K in lymphocyte migration in vivo. In this review we highlight cell-type-specific roles for PI3K catalytic and regulatory subunits in the homing and basal motility of lymphocytes in the intact lymph node.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Oak JS,Matheu MP,Parker I,Cahalan MD,Fruman DAdoi
10.1042/BST0351109subject
Has Abstractpub_date
2007-11-01 00:00:00pages
1109-13issue
Pt 5eissn
0300-5127issn
1470-8752pii
BST0351109journal_volume
35pub_type
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