Abstract:
:The discovery of the zDHHC family of S-acyltransferase enzymes has been one of the major breakthroughs in the S-acylation field. Now, more than a decade since their discovery, major questions centre on profiling the substrates of individual zDHHC enzymes (there are 24 ZDHHC genes and several hundred S-acylated proteins), defining the mechanisms of enzyme-substrate specificity and unravelling the importance of this enzyme family for cellular physiology and pathology.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Lemonidis K,Werno MW,Greaves J,Diez-Ardanuy C,Sanchez-Perez MC,Salaun C,Thomson DM,Chamberlain LHdoi
10.1042/BST20140270subject
Has Abstractpub_date
2015-04-01 00:00:00pages
217-21issue
2eissn
0300-5127issn
1470-8752pii
BST20140270journal_volume
43pub_type
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