Abstract:
:Chromosomal instability occurs early in the development of cancer and may represent an important step in promoting the multiple genetic changes required for the initiation and/or progression of the disease. Telomere erosion is one of the factors that contribute to chromosome instability through end-to-end chromosome fusions entering BFB (breakage-fusion-bridge) cycles. Uncapped chromosomes with short dysfunctional telomeres represent an initiating substrate for both pre- and post-replicative joining, which leads to unstable chromosome rearrangements prone to bridge at mitotic anaphase. Resolution of chromatin bridge intermediates is likely to contribute greatly to the generation of segmental chromosome amplification events, unbalanced chromosome rearrangements and whole chromosome aneuploidy. Accordingly, telomere-driven instability generates highly unstable genomes that could promote cell immortalization and the acquisition of a tumour phenotype.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Tusell L,Pampalona J,Soler D,Frías C,Genescà Adoi
10.1042/BST0381698subject
Has Abstractpub_date
2010-12-01 00:00:00pages
1698-703issue
6eissn
0300-5127issn
1470-8752pii
BST0381698journal_volume
38pub_type
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