Abstract:
:Growing evidence supports the view that LDs (lipid droplets) are dynamic organelles that can serve both as an intracellular signalling compartment and as an organizing platform orchestrating many vital processes in eukaryotic cells. It has become clear that the LDs-confined deposition and lipolytic degradation of neutral lipids define longevity in multicellular eukaryotic organisms and yeast. We summarize the evidence in support of the essential role that LDs play in longevity regulation and propose several molecular mechanisms by which these dynamic organellar compartments control the aging process in multicellular eukaryotes and yeast.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Goldberg AA,Bourque SD,Kyryakov P,Boukh-Viner T,Gregg C,Beach A,Burstein MT,Machkalyan G,Richard V,Rampersad S,Titorenko VIdoi
10.1042/BST0371050subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1050-5issue
Pt 5eissn
0300-5127issn
1470-8752pii
BST0371050journal_volume
37pub_type
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