A novel function of lipid droplets in regulating longevity.

Abstract:

:Growing evidence supports the view that LDs (lipid droplets) are dynamic organelles that can serve both as an intracellular signalling compartment and as an organizing platform orchestrating many vital processes in eukaryotic cells. It has become clear that the LDs-confined deposition and lipolytic degradation of neutral lipids define longevity in multicellular eukaryotic organisms and yeast. We summarize the evidence in support of the essential role that LDs play in longevity regulation and propose several molecular mechanisms by which these dynamic organellar compartments control the aging process in multicellular eukaryotes and yeast.

journal_name

Biochem Soc Trans

authors

Goldberg AA,Bourque SD,Kyryakov P,Boukh-Viner T,Gregg C,Beach A,Burstein MT,Machkalyan G,Richard V,Rampersad S,Titorenko VI

doi

10.1042/BST0371050

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

1050-5

issue

Pt 5

eissn

0300-5127

issn

1470-8752

pii

BST0371050

journal_volume

37

pub_type

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