Abstract:
:VEGFs (vascular endothelial growth factors) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in adults. This family of five mammalian ligands acts through three RTKs (receptor tyrosine kinases). In addition, co-receptors such as NRPs (neuropilins) associate with the ligand-receptor signalling complex and modulate the output. Therapeutics to block several of the VEGF signalling components as well as NRP function have been developed with the aim of halting blood vessel formation, angiogenesis, in diseases that involve tissue growth and inflammation, such as cancer. The present review outlines the current understanding of NRPs in relation to blood and lymphatic vessel biology.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Koch Sdoi
10.1042/BST20110689subject
Has Abstractpub_date
2012-02-01 00:00:00pages
20-5issue
1eissn
0300-5127issn
1470-8752pii
BST20110689journal_volume
40pub_type
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