Collagen polymorphisms of the intervertebral disc.

abstract：:DNA methylation at the fifth position of cytosine is a major epigenetic mark conserved in plants and mammals. Genome-wide DNA methylation patterns are dynamically controlled by integrated activities of establishment, maintenance, and removal. In both plants and mammals, a pattern of global DNA hypomethylation coupled ...

journal_title：Biochemical Society transactions

authors： Zhang H,Zhang K,Zhu JK

更新日期：2019-08-30 00:00:00

abstract：:PLUNC (palate, lung and nasal epithelium clone) proteins make up the largest branch of the BPI (bactericidal/permeability-increasing protein)/LBP (lipopolysaccharide-binding protein) family of lipid-transfer proteins. PLUNCs make up one of the most rapidly evolving mammalian protein families and exhibit low levels of ...

journal_title：Biochemical Society transactions

authors： Bingle CD,Bingle L,Craven CJ

更新日期：2011-08-01 00:00:00

abstract：:An RNA world has been placed centre stage for explaining the origin of life. Indeed, RNA is the most plausible molecule able to form both a (self)-replicator and to inherit information, necessities for initiating genetics. However, in parallel with self-replication, the proto-organism had to obtain the ability to cata...

journal_title：Biochemical Society transactions

authors： Ralser M

更新日期：2014-08-01 00:00:00

abstract：:Cell-free transcription-translation is an expanding field in synthetic biology as a rapid prototyping platform for blueprinting the design of synthetic biological devices. Exemplar efforts include translation of prototype designs into medical test kits for on-site identification of viruses (Zika and Ebola), while gene...

journal_title：Biochemical Society transactions

authors： Moore SJ,MacDonald JT,Freemont PS

更新日期：2017-06-15 00:00:00

abstract：:Many plant viral RNAs lack the 5'-cap structure that is required on all host mRNAs for interacting with essential translation initiation factors. Instead, uncapped viral RNAs take over the host translation machinery by harbouring sequences that functionally replace the 5'-cap. Recent reports reveal at least eight diff...

journal_title：Biochemical Society transactions

authors： Miller WA,Wang Z,Treder K

更新日期：2007-12-01 00:00:00

abstract：:The expression of diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) with predicted molecular mass of 56.9. kDa (BnDGAT1) was examined using microspore-derived cell suspension cultures of oilseed rape (Brassica napus L. cv Jet Neuf). As well, a recombinant histidine-tagged N-terminal fragment of BnDGAT1 [BnDGAT1((1-11...

journal_title：Biochemical Society transactions

authors： Weselake RJ,Nykiforuk CL,Laroche A,Patterson NA,Wiehler WB,Szarka SJ,Moloney MM,Tari LW,Derekh U

更新日期：2000-12-01 00:00:00

abstract：:Chlorophyll metabolism is probably the most visible manifestation of life. In spite of this, chlorophyll catabolism has remained something of a mystery until about 10 years ago. At that time, the first non-green tetrapyrrolic chlorophyll breakdown products from higher plants were discovered, and the structure of the f...

journal_title：Biochemical Society transactions

authors： Kräutler B

更新日期：2002-08-01 00:00:00

abstract：:In order for cells to divide in a proficient manner, they must first double their biomass, which is considered to be the main rate-limiting phase of cell proliferation. Cell growth requires an abundance of energy and biosynthetic precursors such as lipids and amino acids. Consequently, the energy and nutrient status o...

journal_title：Biochemical Society transactions

authors： Dunlop EA,Tee AR

更新日期：2013-08-01 00:00:00

abstract：:Microscopes are used to characterize small objects with the help of probes that interact with the specimen, such as photons and electrons in optical and electron microscopies, respectively. In atomic force microscopy (AFM), the probe is a nanometric tip located at the end of a microcantilever which palpates the specim...

journal_title：Biochemical Society transactions

authors： Moreno-Madrid F,Martín-González N,Llauró A,Ortega-Esteban A,Hernando-Pérez M,Douglas T,Schaap IA,de Pablo PJ

更新日期：2017-04-15 00:00:00

abstract：:Here, I review three new structural studies from our laboratory. First, the crystal structure of RNA polymerase (Pol) II in complex with an RNA inhibitor revealed that this RNA blocks transcription initiation by preventing DNA loading into the active-centre cleft. Secondly, the structure of the SRI (Set2 Rpb1-interact...

journal_title：Biochemical Society transactions

authors： Cramer P

更新日期：2006-12-01 00:00:00

abstract：:Activated tyrosine kinase receptors acquire ubiquitin tags. Ubiquitination governs receptor down-regulation through interaction with components of the endosomal ESCRT (endosomal sorting complexes required for transport) machinery that shepherds receptors into luminal vesicles of multivesicular bodies en route to the l...

journal_title：Biochemical Society transactions

authors： Urbé S,McCullough J,Row P,Prior IA,Welchman R,Clague MJ

更新日期：2006-11-01 00:00:00

abstract：:The development of natural tissues, organs and bodies depends on mechanisms of patterning and of morphogenesis, typically (but not invariably) in that order, and often several times at different final scales. Using synthetic biology to engineer patterning and morphogenesis will both enhance our basic understanding of ...

journal_title：Biochemical Society transactions

authors： Davies JA,Glykofrydis F

更新日期：2020-06-30 00:00:00

abstract：:The secretin receptor is prototypic of Class II GPCRs (G-protein-coupled receptors), based on its structural and functional characteristics and those of its natural agonist ligand. Secretin represents a linear 27-residue peptide with diffuse pharmacophoric domain. The secretin receptor includes the typical signature s...

journal_title：Biochemical Society transactions

authors： Miller LJ,Dong M,Harikumar KG,Gao F

更新日期：2007-08-01 00:00:00

abstract：:Changes in mitochondrial superoxide and hydrogen peroxide production may contribute to various pathologies, and even aging, given that over time and in certain conditions, they damage macromolecules and disrupt normal redox signalling. Mitochondria-targeted antioxidants such as mitoQ, mitoVitE, and mitoTEMPO have open...

journal_title：Biochemical Society transactions

authors： Watson MA,Wong HS,Brand MD

更新日期：2019-10-31 00:00:00

abstract：:XRCC4 (X-ray cross-complementation group 4) and XLF (XRCC4-like factor) are two essential interacting proteins in the human NHEJ (non-homologous end-joining) pathway that repairs DNA DSBs (double-strand breaks). The individual crystal structures show that the dimeric proteins are homologues with protomers containing h...

journal_title：Biochemical Society transactions

authors： Wu Q,Ochi T,Matak-Vinkovic D,Robinson CV,Chirgadze DY,Blundell TL

更新日期：2011-10-01 00:00:00

abstract：:Since the discovery of the essential role of the β-barrel assembly machinery (BAM) for the membrane insertion of outer membrane proteins (OMPs) that are unrelated in sequence, members of this universally conserved family dominate discussions on OMP assembly in bacteria, mitochondria and chloroplasts. However, several ...

journal_title：Biochemical Society transactions

authors： Huysmans GH

更新日期：2016-06-15 00:00:00

abstract：:Most of the effects of the signalling molecule nitric oxide (NO) are mediated by the stimulation of the NO-sensitive GC (guanylate cyclase) and the subsequent increase in cGMP formation. The enzyme contains a prosthetic haem group, which mediates NO stimulation. In addition to the physiological activator NO, NO-sensit...

journal_title：Biochemical Society transactions

authors： Koesling D,Mullershausen F,Lange A,Friebe A,Mergia E,Wagner C,Russwurm M

更新日期：2005-11-01 00:00:00

abstract：:The binding sites of the oestrogen receptors alpha and beta have a structural requirement for ligands with two oxygen atoms (one of which is phenolic) spaced 11-12 A apart. They are open to many non-steroidal compounds, such as those from plants and the chemical industry. The importance of this interaction is the subj...

journal_title：Biochemical Society transactions

authors： Barnes S

更新日期：2001-05-01 00:00:00

abstract：:PTM (post-translational modification) is the chemical modification of a protein after its translation. The well-studied PTM is phosphorylation, but, recently, PTMs have been re-focused by extensive studies on histone modifications and the discovery of the ubiquitin system. Histone acetylation is the well-established e...

journal_title：Biochemical Society transactions

authors： Ito K

更新日期：2007-04-01 00:00:00

abstract：:The respiratory complex I (electrogenic NADH:quinone oxidoreductase) has been considered to act exclusively as a H+ pump. This was questioned when the search for the NADH-driven respiratory Na+ pump in Klebsiella pneumoniae initiated by Peter Dimroth led to the discovery of a Na+-translocating complex in this enteroba...

journal_title：Biochemical Society transactions

authors： Steffen W,Steuber J

更新日期：2013-10-01 00:00:00

abstract：:After years of setbacks, the perspective of neuroprotective stroke therapy has revived in light of recent study results. We outline in this review how a neuroprotective candidate drug should be developed, beginning with a thorough preclinical evaluation according to the STAIR (Stroke Therapy Academic Industry Roundtab...

journal_title：Biochemical Society transactions

authors： Schäbitz WR,Fisher M

更新日期：2006-12-01 00:00:00

abstract：:PINK1 [phosphatase and tensin homologue (PTEN)-induced putative kinase 1] is a serine/threonine kinase targeted to mitochondria and implicated in early-onset recessive Parkinson's disease (PD). Through the phosphorylation of its downstream targets, PINK1 regulates multiple mitochondrial processes, including ATP produc...

journal_title：Biochemical Society transactions

authors： Aerts L,De Strooper B,Morais VA

更新日期：2015-04-01 00:00:00

abstract：:An important aspect of the cytochrome c electrochemistry is the possibility of coupling the 'heterogeneous reactions' with other redox enzymes. Cellobiose dehydrogenase, a 89170 Da glycoprotein that contains both FAD and a b-type haem as prosthetic groups, donates electrons to a number of acceptors, including cytochro...

journal_title：Biochemical Society transactions

authors： Fridman V,Wollenberger U,Bogdanovskaya V,Lisdat F,Ruzgas T,Lindgren A,Gorton L,Scheller FW

更新日期：2000-02-01 00:00:00

abstract：:AS (alternative splicing) and its role in disease, especially cancer, has come to forefront in research over the last few years. Alterations in the ratio of splice variants have been widely observed in cancer. Splice variants of cancer-associated genes have functions that can alter cellular phenotype, ultimately alter...

journal_title：Biochemical Society transactions

authors： Hagen RM,Ladomery MR

更新日期：2012-08-01 00:00:00

abstract：:Protein-protein interactions are a regulatory mechanism for a number of physiological and pathological cellular processes. Neurodegenerative diseases, such as AD (Alzheimer's disease), are associated with the accelerated production or delayed clearance of protein aggregates. Hence, inhibition of pathologic protein-pro...

journal_title：Biochemical Society transactions

authors： Bose M,Gestwicki JE,Devasthali V,Crabtree GR,Graef IA

更新日期：2005-08-01 00:00:00

abstract：:Synthetic gene circuits allow us to govern cell behavior in a programmable manner, which is central to almost any application aiming to harness engineered living cells for user-defined tasks. Transcription factors (TFs) constitute the 'classic' tool for synthetic circuit construction but some of their inherent constra...

journal_title：Biochemical Society transactions

authors： Santos-Moreno J,Schaerli Y

更新日期：2020-10-30 00:00:00

abstract：:The neurotrophins nerve growth factor, brain-derived neurotrophic factor, NT-3 (neurotrophin 3) and NT-4 are known for regulating neuron development, function and survival. Beyond this, neurotrophins were found to exert multiple effects on non-neuronal cells such as immune cells, smooth muscle and epithelial cells. In...

journal_title：Biochemical Society transactions

authors： Rochlitzer S,Nassenstein C,Braun A

更新日期：2006-08-01 00:00:00

abstract：:Glucotoxicity plays a major role in pancreatic beta-cell apoptosis and diabetes progression, but the factors involved have remained largely unknown. Our recent studies have identified TXNIP (thioredoxin-interacting protein) as a novel pro-apoptotic beta-cell factor that is induced by glucose, suggesting that TXNIP may...

journal_title：Biochemical Society transactions

authors： Shalev A

更新日期：2008-10-01 00:00:00

abstract：:Glycation is one of the important reactions regulating physiological state, and glycative stress, namely an overwhelming and unfavourable glycation state, is established as a pathological factor. Glycative stress is closely associated with not only various kidney diseases, but also kidney aging. Accumulating evidence,...

journal_title：Biochemical Society transactions

authors： Inagi R

更新日期：2014-04-01 00:00:00

abstract：:Genetic experiments have established an important role for the ubiquitin-like molecule NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8) in the regulation of cell growth, viability and development. It is therefore essential to identify the molecular targets for the pathway. Until recently, the c...

journal_title：Biochemical Society transactions

authors： Xirodimas DP

更新日期：2008-10-01 00:00:00