Abstract:
:AS (alternative splicing) and its role in disease, especially cancer, has come to forefront in research over the last few years. Alterations in the ratio of splice variants have been widely observed in cancer. Splice variants of cancer-associated genes have functions that can alter cellular phenotype, ultimately altering metastatic potential. As metastases are the cause of approximately 90% of all human cancer deaths, it is crucial to understand how AS is dysregulated in metastatic disease. We highlight some recent studies into the relationship between altered AS of key genes and the initiation of prostate cancer metastasis.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Hagen RM,Ladomery MRdoi
10.1042/BST20120026subject
Has Abstractpub_date
2012-08-01 00:00:00pages
870-4issue
4eissn
0300-5127issn
1470-8752pii
BST20120026journal_volume
40pub_type
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