Abstract:
:PINK1 [phosphatase and tensin homologue (PTEN)-induced putative kinase 1] is a serine/threonine kinase targeted to mitochondria and implicated in early-onset recessive Parkinson's disease (PD). Through the phosphorylation of its downstream targets, PINK1 regulates multiple mitochondrial processes, including ATP production, stress-response and mitochondrial dynamics and quality control. The orchestration of such a wide array of functions by an individual kinase requires a fine-tuned and versatile regulation of its activity. PINK1 proteolytic processing, trafficking and localization, as well as different post-translational modifications, affect its activity and function. Unravelling the regulatory mechanisms of PINK1 is essential for a full comprehension of its kinase function in health and disease.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Aerts L,De Strooper B,Morais VAdoi
10.1042/BST20150002subject
Has Abstractpub_date
2015-04-01 00:00:00pages
280-6issue
2eissn
0300-5127issn
1470-8752pii
BST20150002journal_volume
43pub_type
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