Abstract:
:PLUNC (palate, lung and nasal epithelium clone) is a small, secreted protein that is expressed in the oropharynx and upper airways of humans, mice and rats. We have described a family of at least 14 PLUNC genes localized on chromosome 20 (in humans), 2 (in mice) or 3 (in rats). These rapidly evolving proteins are structurally related to lipopolysaccharide-binding protein (LBP) and bactericidal/permeability-increasing protein (BPI). In the present analysis we comment on the comparative aspects of this protein family, which may function to protect epithelial surfaces from pathogenic micro-organisms.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Bingle CD,Craven CJdoi
10.1042/bst0310806keywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
806-9issue
Pt 4eissn
0300-5127issn
1470-8752journal_volume
31pub_type
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