A progress report on the crystallographic studies on the B800-850 antenna complex from Rhodopseudomonas acidophila strain 10050.

Abstract:

:Large single crystals (up to 1 mm in each dimension) of the B800-850 antenna complex from Rhodopseudomonas acidophila strain 10050 have been grown in the presence of beta-octyl-glucoside. These crystals have the space group R32 and unit cell dimensions of a = b = 119.9 A and c = 297.0 A. Recently we have improved our crystallization procedures so that all crystals now diffract reliably to beyond 3.5 A, with some diffracting to below 3 A. A range of isomorphous heavy atom derivatives have been prepared and we are now engaged in locating the heavy atom sites within the unit cell.

journal_name

Biochem Soc Trans

authors

Cogdell RJ,Halloren E,Hawthornthwaite AM,Thunnissen MM,Freer AA,McDermott G,Guthrie N,Isaacs N,Lindsay JG,Papiz M

doi

10.1042/bst0210039

subject

Has Abstract

pub_date

1993-02-01 00:00:00

pages

39-40

issue

1

eissn

0300-5127

issn

1470-8752

journal_volume

21

pub_type

杂志文章
  • Cytokinesis: the final stop for the chromosomal passengers.

    abstract::The CPC (chromosomal passenger complex) performs essential roles in the regulation and co-ordination of chromosomal and cytoskeletal events during mitosis and meiosis. The first functional analyses showed evidence of a role of the CPC in the regulation of cytokinesis. In this review, I summarize what we have learned s...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0360367

    authors: Carmena M

    更新日期:2008-06-01 00:00:00

  • Polyamine biosynthetic enzymes as drug targets in parasitic protozoa.

    abstract::Molecular, biochemical and genetic characterization of ornithine decarboxylase, S -adenosylmethionine decarboxylase and spermidine synthase establishes that these polyamine-biosynthetic enzymes are essential for growth and survival of the agents that cause African sleeping sickness, Chagas' disease, leishmaniasis and ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0310415

    authors: Heby O,Roberts SC,Ullman B

    更新日期:2003-04-01 00:00:00

  • Folding outer membrane proteins independently of the β-barrel assembly machinery: an assembly pathway for multimeric complexes?

    abstract::Since the discovery of the essential role of the β-barrel assembly machinery (BAM) for the membrane insertion of outer membrane proteins (OMPs) that are unrelated in sequence, members of this universally conserved family dominate discussions on OMP assembly in bacteria, mitochondria and chloroplasts. However, several ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20160003

    authors: Huysmans GH

    更新日期:2016-06-15 00:00:00

  • Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe.

    abstract::The fission yeast Schizosaccharomyces pombe primarily detects glucose via a cAMP-signalling pathway. Components of this pathway include the Git3 G-protein-coupled receptor and a heterotrimeric G-protein, from which the Gpa2 Galpha subunit activates adenylate cyclase (Git2/Cyr1). Three additional proteins, Git1, Git7 a...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0330257

    authors: Hoffman CS

    更新日期:2005-02-01 00:00:00

  • Tetraspanin CD9 in cell migration.

    abstract::Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion. Pro- and anti-migratory effects of CD9 have been linked to adhesion-dependent signalling pathways, including phosphorylation of FAK (focal adhesion kinase) and activatio...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0390563

    authors: Powner D,Kopp PM,Monkley SJ,Critchley DR,Berditchevski F

    更新日期:2011-04-01 00:00:00

  • Residual dipolar couplings as a tool to study molecular recognition of ubiquitin.

    abstract::RDCs (residual dipolar couplings) in NMR spectroscopy provide information about protein dynamics complementary to NMR relaxation methods, especially in the previously inaccessible time window between the protein correlation time tau(c) and 50 micros. For ubiquitin, new modes of motion of the protein backbone could be ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0361433

    authors: Lakomek NA,Lange OF,Walter KF,Farès C,Egger D,Lunkenheimer P,Meiler J,Grubmüller H,Becker S,de Groot BL,Griesinger C

    更新日期:2008-12-01 00:00:00

  • Alkalithermophiles.

    abstract::Alkalithermophiles are an exciting subset of extremophilic organisms and represent extremophiles that are adapted to two extreme conditions, i.e. to a combination of alkaline and thermobiotic growth conditions. Among the anaerobic alkalithermophiles are representatives of both Bacteria and Archaea within a wide variet...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/bst0320193

    authors: Wiegel J,Kevbrin VV

    更新日期:2004-04-01 00:00:00

  • Talks about TORCs: recent advancesin target of rapamycin signalling. On mTOR nomenclature.

    abstract::In the present article, I discuss recent developments in the naming of the TOR (target of rapamycin) protein. In particular, I address the issue of mammalian target of rapamycin (mTOR) versus the newer mechanistic target of rapamycin (MTOR). mTOR is the name given by the TOR community almost two decades ago and widely...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20130092

    authors: Hall MN

    更新日期:2013-08-01 00:00:00

  • Molecular mechanism of force generation by dynein, a molecular motor belonging to the AAA+ family.

    abstract::Dynein is an AAA+ (ATPase associated with various cellular activities)-type motor complex that utilizes ATP hydrolysis to actively drive microtubule sliding. The dynein heavy chain (molecular mass >500 kDa) contains six tandemly linked AAA+ modules and exhibits full motor activities. Detailed molecular dissection of t...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0360131

    authors: Numata N,Kon T,Shima T,Imamula K,Mogami T,Ohkura R,Sutoh K,Sutoh K

    更新日期:2008-02-01 00:00:00

  • Engineering tissue for the fetus: stem cells and matrix signalling.

    abstract::Congenital malformations are major causes of disease and death during the first years of life and, most of the time, functional replacement of the missing or damaged organs remains an unmet clinical need. Particularly relevant for the treatment of congenital malformation would be to collect the stem cells at diagnosis...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20140069

    authors: De Coppi P

    更新日期:2014-06-01 00:00:00

  • New insights into the mechanisms of lipid-body biogenesis in plants and other organisms.

    abstract::A comparative approach has been used to study the role of several lipid-body-binding proteins in plants and animals. Caleosins are a newly discovered class of calcium-binding lipid-body proteins found in plants and fungi, which we now report to have separate endoplasmic reticulum- and lipid-body-associated isoforms. W...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:

    authors: Murphy DJ,Hernendez-Pinzon I,Patel K,Hope RG,McLauchlan J

    更新日期:2000-12-01 00:00:00

  • Electrocatalytic reduction of nitrate and selenate by NapAB.

    abstract::Bacterial cellular metabolism is renowned for its metabolic diversity and adaptability. However, certain environments present particular challenges. Aerobic metabolism of highly reduced carbon substrates by soil bacteria such as Paracoccus pantotrophus presents one such challenge since it may result in excessive elect...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0390236

    authors: Gates AJ,Butler CS,Richardson DJ,Butt JN

    更新日期:2011-01-01 00:00:00

  • Ligand migration and escape pathways in haem proteins.

    abstract::Biophysical techniques developed during the last three decades have provided an increasingly detailed description of the internal processes associated with ligand capture and release by haem proteins. Myoglobin has long been the paradigm for these studies. More recently, cytochrome P450cam (the camphor-metabolizing cy...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0340975

    authors: Lavalette D,Tétreau C,Mouawad L

    更新日期:2006-11-01 00:00:00

  • Nutritional influences on the gut microbiota and the consequences for gastrointestinal health.

    abstract::The human colonic microbiota degrades dietary substrates that are indigestible in the upper GIT (gastrointestinal tract), releasing bacterial metabolites, some of which are important for gut health. Advances in molecular biology techniques have facilitated detailed analyses of the composition of the bacterial communit...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0391073

    authors: Scott KP,Duncan SH,Louis P,Flint HJ

    更新日期:2011-08-01 00:00:00

  • Looking for novel functions of tau.

    abstract::The lack or excess of the protein tau can be deleterious for neurons. The absence of tau can result in retarded neurogenesis and neuronal differentiation, although adult mice deficient in tau are viable, probably because of the compensation of the loss of tau by other MAPs (microtubule-associated proteins). On the con...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20120006

    authors: Avila J,de Barreda EG,Fuster-Matanzo A,Simón D,Llorens-Martín M,Engel T,Lucas JJ,Díaz-Hernández M,Hernández F

    更新日期:2012-08-01 00:00:00

  • Signalling networks, inflammation and innate immunity.

    abstract::We have been analysing the signalling systems that couple to receptors of the TIR (Toll/interleukin-1 receptor) family, which signal through a common cytoplasm region; the TIR domain. These systems are of both practical and fundamental biological significance, being central to the pathogenesis of chronic inflammatory ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0311462

    authors: Dower SK,Qwarnstrom EE

    更新日期:2003-12-01 00:00:00

  • Macrophage apoptosis in host immunity to mycobacterial infections.

    abstract::Macrophage apoptosis occurs within the granuloma, which is essential for successful immunity to tuberculosis. In vitro macrophage apoptosis is associated with the killing of intracellular Mycobacterium tuberculosis. A greater understanding of these observations will lead to new immunotherapies and improved vaccine des...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0320496

    authors: Fairbairn IP

    更新日期:2004-06-01 00:00:00

  • Before and beyond ABA: upstream sensing and internal signals that determine ABA accumulation and response under abiotic stress.

    abstract::Sensing and signalling events that detect abiotic stress-induced changes in plant water status and initiate downstream stress responses such as ABA (abscisic acid) accumulation and osmoregulation remain uncharacterized in plants. Although conclusive results are lacking, recent results from plants, and analogies to sig...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0330375

    authors: Verslues PE,Zhu JK

    更新日期:2005-04-01 00:00:00

  • An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells.

    abstract::The UPR (unfolded protein response) or ER (endoplasmic reticulum) stress response was first described 20 years ago. The field of ER stress has expanded tremendously since, moving from basic biology in yeast to human neurodegenerative, inflammatory, cardiovascular and neoplastic diseases. The ER stress response has als...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0360909

    authors: Cnop M,Igoillo-Esteve M,Cunha DA,Ladrière L,Eizirik DL

    更新日期:2008-10-01 00:00:00

  • Ran at kinetochores.

    abstract::The Ran GTPase controls many cellular functions, including nucleocytoplasmic trafficking, spindle assembly, nuclear assembly and cell-cycle progression. Considerable evidence suggests that diffusible Ran-GTP near mitotic chromatin facilitates the release of critical factors from nuclear transport receptors, thereby pr...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0340711

    authors: Dasso M

    更新日期:2006-11-01 00:00:00

  • Apoptosis-like programmed cell death in the grey mould fungus Botrytis cinerea: genes and their role in pathogenicity.

    abstract::A considerable number of fungal homologues of human apoptotic genes have been identified in recent years. Nevertheless, we are far from being able to connect the different pieces and construct a primary structure of the fungal apoptotic regulatory network. To get a better picture of the available fungal components, we...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0391493

    authors: Shlezinger N,Doron A,Sharon A

    更新日期:2011-10-01 00:00:00

  • The use of fluorescence correlation spectroscopy to characterize the molecular mobility of fluorescently labelled G protein-coupled receptors.

    abstract::The membranes of living cells have been shown to be highly organized into distinct microdomains, which has spatial and temporal consequences for the interaction of membrane bound receptors and their signalling partners as complexes. Fluorescence correlation spectroscopy (FCS) is a technique with single cell sensitivit...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20150285

    authors: Kilpatrick LE,Hill SJ

    更新日期:2016-04-15 00:00:00

  • Lysosomal membrane proteins: life between acid and neutral conditions.

    abstract::Whereas we have a profound understanding about the function and biogenesis of the protein constituents in the lumen of the lysosomal compartment, much less is known about the functions of proteins of the lysosomal membrane. Proteomic analyses of the lysosomal membrane suggest that, apart from the well-known lysosomal ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0381420

    authors: Saftig P,Schröder B,Blanz J

    更新日期:2010-12-01 00:00:00

  • ERK5 and its role in tumour development.

    abstract::The MEK5 [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase 5]/ERK5 pathway is the least well studied MAPK signalling module. It has been proposed to play a role in the pathology of cancer. In the present paper, we review the role of the MEK5/ERK5 pathway using the 'hallmarks o...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20110663

    authors: Lochhead PA,Gilley R,Cook SJ

    更新日期:2012-02-01 00:00:00

  • Knot localization in proteins.

    abstract::The backbones of proteins form linear chains. In the case of some proteins, these chains can be characterized as forming linear open knots. The knot type of the full chain reveals only limited information about the entanglement of the chain since, for example, subchains of an unknotted protein can form knots and subch...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20120329

    authors: Rawdon EJ,Millett KC,Sułkowska JI,Stasiak A

    更新日期:2013-04-01 00:00:00

  • Structure and chemistry of the Sir2 family of NAD+-dependent histone/protein deactylases.

    abstract::The yeast Sir2 (silent information regulator-2) protein functions as an NAD(+)-dependent histone deacetylase to silence gene expression from the mating-type locus, tolomeres and rDNA and also promotes longevity and genome stability in response to calorie restriction. Homologues of yeast Sir2 have been identified in th...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0320904

    authors: Marmorstein R

    更新日期:2004-12-01 00:00:00

  • Post-transcriptional control of mitochondrial protein composition in changing environmental conditions.

    abstract::In fluctuating environmental conditions, organisms must modulate their bioenergetic production in order to maintain cellular homeostasis for optimal fitness. Mitochondria are hubs for metabolite and energy generation. Mitochondria are also highly dynamic in their function: modulating their composition, size, density, ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20200250

    authors: Tsuboi T,Leff J,Zid BM

    更新日期:2020-11-27 00:00:00

  • Highly glycosylated tumour antigens: interactions with the immune system.

    abstract::A common phenotypic change in cancer is a dramatic transformation of cellular glycosylation. Functional studies of particular tumour-associated oligosaccharides are difficult to interpret conclusively, but carbohydrate-binding proteins are likely to contribute to progression of the tumour. This review discusses the po...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0390388

    authors: Saeland E,van Kooyk Y

    更新日期:2011-01-01 00:00:00

  • Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition.

    abstract::The Ets family of eukaryotic transcription factors is based around the conserved Ets DNA-binding domain. Although their DNA-binding selectivity is biochemically and structurally well characterized, structures of homodimeric and ternary complexes point to Ets domains functioning as versatile protein-interaction modules...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20130227

    authors: Cooper CD,Newman JA,Gileadi O

    更新日期:2014-02-01 00:00:00

  • Expression, purification and properties of multidrug efflux proteins.

    abstract::A general strategy is described for the amplified expression, purification and characterization in Escherichia coli of multidrug efflux proteins from Staphylococcus aureus, Bacillus subtilis, Methanococcus janaschii and E. coli. They all catalyse drug/H(+) antiport of substrates such as quinolones and ethidium and exe...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:

    authors: Henderson PJ,Hoyle CK,Ward A

    更新日期:2000-01-01 00:00:00