Abstract:
:The human prostate expresses very high concentrations of annexins 1, 4, and 5 and secretes high concentrations of annexins 1 and 5. Although the biological roles of these proteins in prostate secretions are not known, these studies emphasize the need to consider extracellular sites for physiological functions of annexins. The clear demonstration of secretion of proteins that have blocked N-termini and lack hydrophobic signal sequences raises the possibility that novel cellular secretory pathways exist. Preliminary immunohistochemical experiments in collaboration with Dr. James Fallon indicate that both annexins 1 and 4 are expressed in prostate ductal secretory epithelium. Since annexin 1, but not annexin 4, is secreted, a comparison of the cellular fate of these two related proteins in the prostate may provide a useful model system for determining the structural elements that direct the secretion of proteins which lack conventional signal sequences.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Haigler HT,Christmas Pdoi
10.1042/bst0181104subject
Has Abstractpub_date
1990-12-01 00:00:00pages
1104-6issue
6eissn
0300-5127issn
1470-8752journal_volume
18pub_type
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