Abstract:
:Higher eukaryotes rely on AS (alternative splicing) of pre-mRNAs (mRNA precursors) to generate more than one protein product from a single gene and to regulate mRNA stability and translational activity. An important example of the latter function involves an interplay between AS and NMD (nonsense-mediated decay), a cytoplasmic quality control mechanism eliminating mRNAs containing PTCs (premature translation termination codons). Although originally identified as an error surveillance process, AS-NMD additionally provides an efficient strategy for deterministic regulation of gene expression outputs. In this review, we discuss recently published examples of AS-NMD and delineate functional contexts where recurrent use of this mechanism orchestrates expression of important genes.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Hamid FM,Makeyev EVdoi
10.1042/BST20140066subject
Has Abstractpub_date
2014-08-01 00:00:00pages
1168-73issue
4eissn
0300-5127issn
1470-8752pii
BST20140066journal_volume
42pub_type
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