Abstract:
:The avascular nature of the human intervertebral disc is thought to reduce the ability of resident disc cells to maintain their extracellular matrix, rendering the tissue susceptible to degeneration. It has also been suggested that the lack of a blood supply may result in disc cell death via nutrient deprivation. Therefore transplanting new cells into the disc to promote tissue regeneration would be akin to 'putting cells in a coffin' and doomed to failure. This review considers the available evidence for cell death in the human intervertebral disc, describing briefly the methods used to assay such death, and concludes that further analysis is required to ascertain whether extensive cell death truly is a marked feature of human intervertebral discs and whether it bears any relationship to disc degeneration and hence regenerative strategies.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Johnson WE,Roberts Sdoi
10.1042/BST0350680subject
Has Abstractpub_date
2007-08-01 00:00:00pages
680-2issue
Pt 4eissn
0300-5127issn
1470-8752pii
BST0350680journal_volume
35pub_type
杂志文章,评审abstract::Gap junctions are channels which allow electrical signals to propagate through the heart from the sinoatrial node and through the atria, conduction system and onwards to the ventricles, and hence are essential for co-ordinated cardiac contraction. Twelve connexin (Cx) proteins make up one gap junction channel, of whic...
journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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abstract::The CGRP (calcitonin gene-related peptide) receptor is a family B GPCR (G-protein-coupled receptor). It consists of a GPCR, CLR (calcitonin receptor-like receptor) and an accessory protein, RAMP1 (receptor activity modifying protein 1). RAMP1 is needed for CGRP binding and also cell-surface expression of CLR. CLR is a...
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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更新日期:2012-08-01 00:00:00
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journal_title:Biochemical Society transactions
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更新日期:2007-08-01 00:00:00
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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更新日期:2010-02-01 00:00:00
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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更新日期:2018-02-19 00:00:00