Dissecting the role of His domain protein tyrosine phosphatase/PTPN23 and ESCRTs in sorting activated epidermal growth factor receptor to the multivesicular body.

Abstract:

:Sorting of activated epidermal growth factor receptor (EGFR) into intraluminal vesicles (ILVs) within the multivesicular body (MVB) is an essential step during the down-regulation of the receptor. The machinery that drives EGFR sorting attaches to the cytoplasmic face of the endosome and generates vesicles that bud into the endosome lumen, but somehow escapes encapsulation itself. This machinery is termed the ESCRT (endosomal sorting complexes required for transport) pathway, a series of multi-protein complexes and accessory factors first identified in yeast. Here, we review the yeast ESCRT pathway and describe the corresponding components in mammalian cells that sort EGFR. One of these is His domain protein tyrosine phosphatase (HD-PTP/PTPN23), and we review the interactions involving HD-PTP and ESCRTs. Finally, we describe a working model for how this ESCRT pathway might overcome the intrinsic topographical problem of EGFR sorting to the MVB lumen.

journal_name

Biochem Soc Trans

authors

Tabernero L,Woodman P

doi

10.1042/BST20170443

subject

Has Abstract

pub_date

2018-10-19 00:00:00

pages

1037-1046

issue

5

eissn

0300-5127

issn

1470-8752

pii

BST20170443

journal_volume

46

pub_type

杂志文章,评审
  • Presenilins: how much more than γ-secretase?!

    abstract::AD (Alzheimer's disease) is a neurodegenerative disease characterized by a gradual loss of neurons and the accumulation of neurotoxic Aβ (amyloid β-peptide) and hyperphosphorylated tau. The discovery of mutations in three genes, PSEN1 (presenilin 1), PSEN2 (presenilin 2) and APP (amyloid precursor protein), in patient...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0381474

    authors: Coen K,Annaert W

    更新日期:2010-12-01 00:00:00

  • Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling.

    abstract::ESCs (embryonic stem cells) are derived from the inner cell mass of pre-implantation embryos and are pluripotent, meaning they can differentiate into all of the cells that make up the adult organism. This property of pluripotency makes ESCs attractive as a model system for studying early development and for the genera...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0390674

    authors: Welham MJ,Kingham E,Sanchez-Ripoll Y,Kumpfmueller B,Storm M,Bone H

    更新日期:2011-04-01 00:00:00

  • Conserved roles for peptidases in the processing of invertebrate neuropeptides.

    abstract::Invertebrates use a wide range of peptides as transmitters and hormones to regulate complex behaviour, physiology and development. These animals, especially those that are amenable to genetic study and are the subject of genome-sequencing projects, provide powerful model systems for understanding the functions of pept...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:

    authors: Isaac RE,Siviter RJ,Stancombe P,Coates D,Shirras AD

    更新日期:2000-01-01 00:00:00

  • The polymorphic telomeres of the African Trypanosome trypanosoma brucei.

    abstract::African trypanosomes have plastic genomes with extensive variability at the chromosome ends. The genes encoding the expressed major surface protein of the infective bloodstream form stages of Trypanosoma brucei and are located at telomeres. These telomeric expression-site transcription units are turning out to be surp...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0280536

    authors: Rudenko G

    更新日期:2000-10-01 00:00:00

  • Study of prostaglandin receptors in mitochondria on apoptosis of human lung carcinoma cell line A549.

    abstract::PGs (prostaglandins) are synthesized through the cyclo-oxygenase (COX-1 and -2) pathway in a variety of cells in response to various physiological stimuli. All cells require at least one pathway for apoptosis, and mitochondrial play a central role in regulation of apoptosis. In a previous study, incubation of A549 cel...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0321078

    authors: Fang KM,Shu WH,Chang HC,Wang JJ,Mak OT

    更新日期:2004-12-01 00:00:00

  • Crop reproductive meristems in the genomic era: a brief overview.

    abstract::Modulation of traits beneficial for cultivation and yield is one of the main goals of crop improvement. One of the targets for enhancing productivity is changing the architecture of inflorescences since in many species it determines fruit and seed yield. Inflorescence shape and organization is genetically established ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20190441

    authors: Caselli F,Zanarello F,Kater MM,Battaglia R,Gregis V

    更新日期:2020-06-30 00:00:00

  • Papillomaviruses and the host SUMOylation system.

    abstract::SUMOylation of viral proteins is widespread and serves to modify or regulate the properties of those proteins. Papillomaviruses are a large group of small DNA viruses that infect the skin, leading to benign lesions (warts) that in some cases can progress to malignancy. The papillomavirus life cycle is intimately conne...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0351433

    authors: Wu YC,Deyrieux AF,Wilson VG

    更新日期:2007-12-01 00:00:00

  • Expression and properties of diacylglycerol acyltransferase from cell-suspension cultures of oilseed rape.

    abstract::The expression of diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) with predicted molecular mass of 56.9. kDa (BnDGAT1) was examined using microspore-derived cell suspension cultures of oilseed rape (Brassica napus L. cv Jet Neuf). As well, a recombinant histidine-tagged N-terminal fragment of BnDGAT1 [BnDGAT1((1-11...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:

    authors: Weselake RJ,Nykiforuk CL,Laroche A,Patterson NA,Wiehler WB,Szarka SJ,Moloney MM,Tari LW,Derekh U

    更新日期:2000-12-01 00:00:00

  • Emerging paradigms for PilZ domain-mediated C-di-GMP signaling.

    abstract::PilZ domain-containing proteins constitute a large family of bacterial signaling proteins. As a widely distributed protein domain for the binding of the second messenger c-di-GMP, the canonical PilZ domain contains a set of motifs that define the binding site for c-di-GMP and an allosteric switch for propagating local...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20180543

    authors: Cheang QW,Xin L,Chea RYF,Liang ZX

    更新日期:2019-02-28 00:00:00

  • Red light, green light: probing single molecules using alternating-laser excitation.

    abstract::Single-molecule fluorescence methods, particularly single-molecule FRET (fluorescence resonance energy transfer), have provided novel insights into the structure, interactions and dynamics of biological systems. ALEX (alternating-laser excitation) spectroscopy is a new method that extends single-molecule FRET by provi...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0360738

    authors: Santoso Y,Hwang LC,Le Reste L,Kapanidis AN

    更新日期:2008-08-01 00:00:00

  • Plant cell divisions: variations from the shortest symmetric path.

    abstract::In plants, the spatial arrangement of cells within tissues and organs is a direct consequence of the positioning of the new cell walls during cell division. Since the nineteenth century, scientists have proposed rules to explain the orientation of plant cell divisions. Most of these rules predict the new wall will fol...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20200529

    authors: Serra L,Robinson S

    更新日期:2020-12-18 00:00:00

  • Insight into stability of CotA laccase from the spore coat of Bacillus subtilis.

    abstract::The axial ligand of the catalytic mononuclear T1 copper site (Met(502)) of the CotA laccase was replaced by a leucine or phenylalanine residue to increase the redox potential of the enzyme. These mutations led to an increase in the redox potential by approx. 100 mV relative to the wild-type enzyme but the catalytic co...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0351579

    authors: Melo EP,Fernandes AT,Durão P,Martins LO

    更新日期:2007-12-01 00:00:00

  • Tetraspanins in the humoral immune response.

    abstract::The tetraspanins represent a large superfamily of four-transmembrane proteins that are expressed on all nucleated cells. Tetraspanins play a prominent role in the organization of the plasma membrane by co-ordinating the spatial localization of transmembrane proteins and signalling molecules into 'tetraspanin microdoma...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0390512

    authors: van Spriel AB

    更新日期:2011-04-01 00:00:00

  • Thiol regulation of pro-inflammatory cytokines and innate immunity: protein S-thiolation as a novel molecular mechanism.

    abstract::Inflammation or inflammatory cytokines and oxidative stress have often been associated, and thiol antioxidants, particularly glutathione, have often been seen as possible anti-inflammatory mediators. However, whereas several cytokine inhibitors have been approved for drug use in chronic inflammatory diseases, this has...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0391268

    authors: Coppo L,Ghezzi P

    更新日期:2011-10-01 00:00:00

  • Grouping of odorant receptors: odour maps in the mammalian olfactory bulb.

    abstract::The olfactory system is unique in that the sensory input is in the form of molecular information carried in a vast variety of odorants. Nearly 1000 types of odorant receptors mediate the initial detection and discrimination of odorants at the molecular-feature level. The discrimination at the molecular level is conver...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0310134

    authors: Mori K

    更新日期:2003-02-01 00:00:00

  • Coupling the dynamics of two actin networks--new views on the mechanics of cell protrusion.

    abstract::We study how mechanical forces integrate spatially and temporally with regulatory signals at the leading edge of migrating cells. To probe the dynamics of this system, we developed quantitative fluorescent speckle microscopy, which maps out actin cytoskeleton transport, assembly and disassembly with high spatial resol...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20051250

    authors: Danuser G

    更新日期:2005-12-01 00:00:00

  • Regional differences in protein production by human adipose tissue.

    abstract::Human adipose tissue has an important protein secretory function. Cytokines, hormones, prohormones and enzymes are secreted from fat cells and act in an endocrine or paracrine fashion. The production of several of these proteins is affected by obesity; normally there is an increase in the obese state. Protein producti...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0290072

    authors: Arner P

    更新日期:2001-05-01 00:00:00

  • CYP74C3 and CYP74A1, plant cytochrome P450 enzymes whose activity is regulated by detergent micelle association, and proposed new rules for the classification of CYP74 enzymes.

    abstract::CYP74C3 (cytochrome P450 subfamily 74C3), an HPL (hydroperoxide lyase) from Medicago truncatula (barrel medic), and CYP74A1, an AOS (allene oxide synthase) from Arabidopsis thaliana, are key membrane-associated P450 enzymes in plant oxylipin metabolism. Both recombinant detergent-free enzymes are monomeric proteins wi...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0341223

    authors: Hughes RK,Belfield EJ,Casey R

    更新日期:2006-12-01 00:00:00

  • HDAC inhibitors as cognitive enhancers in fear, anxiety and trauma therapy: where do we stand?

    abstract::A novel strategy to treat anxiety and fear-related disorders such as phobias, panic and PTSD (post-traumatic stress disorder) is combining CBT (cognitive behavioural therapy), including extinction-based exposure therapy, with cognitive enhancers. By targeting and boosting mechanisms underlying learning, drug developme...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20130233

    authors: Whittle N,Singewald N

    更新日期:2014-04-01 00:00:00

  • Imaging tumour heterogeneity of the consequences of a PKCα-substrate interaction in breast cancer patients.

    abstract::Breast cancer heterogeneity demands that prognostic models must be biologically driven and recent clinical evidence indicates that future prognostic signatures need evaluation in the context of early compared with late metastatic risk prediction. In pre-clinical studies, we and others have shown that various protein-p...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20140165

    authors: Weitsman G,Lawler K,Kelleher MT,Barrett JE,Barber PR,Shamil E,Festy F,Patel G,Fruhwirth GO,Huang L,Tullis ID,Woodman N,Ofo E,Ameer-Beg SM,Irshad S,Condeelis J,Gillett CE,Ellis PA,Vojnovic B,Coolen AC,Ng T

    更新日期:2014-12-01 00:00:00

  • In Saccharomyces cerevisiae, impaired PRPP synthesis is accompanied by valproate and Li+ sensitivity.

    abstract::The biosynthetic intermediate PRPP (phosphoribosylpyrophosphate) has a central role in cellular biochemistry since it links carbon and nitrogen metabolism. Its importance may be reflected in the fact that, in the Saccharomyces cerevisiae (yeast) genome, there are five unlinked genes, PRS1-PRS5, each of which is theore...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20051154

    authors: Vavassori S,Wang K,Schweizer LM,Schweizer M

    更新日期:2005-11-01 00:00:00

  • Mechanism and role of localized activation of Rho-family GTPases in growth factor-stimulated fibroblasts and neuronal cells.

    abstract::Rho-family GTPases regulate various aspects of cell function by controlling cytoskeletal changes; however, their spatial regulation within the cells remains largely unknown. To understand this regulation, we have studied the spatiotemporal activity of Rho-family GTPases in migrating cells and growth factor-stimulated ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0330631

    authors: Kurokawa K,Nakamura T,Aoki K,Matsuda M

    更新日期:2005-08-01 00:00:00

  • The assimilatory nitrate reduction system of the phototrophic bacterium Rhodobacter capsulatus E1F1.

    abstract::The phototrophic bacterium Rhodobacter capsulatus E1F1 assimilates nitrate under anaerobic phototrophic growth conditions. A 17 kb DNA region encoding the nitrate assimilation (nas) system of this bacterium has been cloned and sequenced. This region includes the genes coding for a putative ABC (ATP-binding cassette)-t...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0340127

    authors: Pino C,Olmo-Mira F,Cabello P,Martínez-Luque M,Castillo F,Roldán MD,Moreno-Vivián C

    更新日期:2006-02-01 00:00:00

  • Electrical consequences of cardiac myocyte: fibroblast coupling.

    abstract::Gap junctions are channels which allow electrical signals to propagate through the heart from the sinoatrial node and through the atria, conduction system and onwards to the ventricles, and hence are essential for co-ordinated cardiac contraction. Twelve connexin (Cx) proteins make up one gap junction channel, of whic...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20150035

    authors: McArthur L,Chilton L,Smith GL,Nicklin SA

    更新日期:2015-06-01 00:00:00

  • The effect of carbohydrates on the greening of plant cultures.

    abstract::Sugars that are readily respired by plant cells inhibit greening when dO2 and mu are relatively high. As sugar concentration in the batch culture medium is depleted and mu declines, greening is permitted. The mechanism of this effect has not been satisfactorily explained. ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/bst0080475

    authors: Dalton C

    更新日期:1980-08-01 00:00:00

  • Studying biomolecular complexes with pulsed electron-electron double resonance spectroscopy.

    abstract::The function of biomolecules is intrinsically linked to their structure and the complexes they form during function. Techniques for the determination of structures and dynamics of these nanometre assemblies are therefore important for an understanding on the molecular level. PELDOR (pulsed electron-electron double res...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0390128

    authors: Reginsson GW,Schiemann O

    更新日期:2011-01-01 00:00:00

  • LRRK2 and autophagy: a common pathway for disease.

    abstract::LRRK2 (leucine-rich repeat kinase 2) is an enzyme implicated in human disease, containing kinase and GTPase functions within the same multidomain open reading frame. Dominant mutations in the LRRK2 gene are the most common cause of familial PD (Parkinson's disease). Additionally, in genome-wide association studies, th...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20120126

    authors: Manzoni C

    更新日期:2012-10-01 00:00:00

  • Role of myristoylation in the intracellular targeting of neuronal calcium sensor (NCS) proteins.

    abstract::The control of the intracellular localization of NCS (neuronal calcium sensor) proteins is of importance for their ability to respond appropriately to differing calcium signals. We examine the localization of three NCS proteins: NCS-1, KChIP-1 (potassium-channel-interacting protein 1) and hippocalcin. Additionally, th...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0310963

    authors: O'Callaghan DW,Burgoyne RD

    更新日期:2003-10-01 00:00:00

  • Translation initiation in the crenarchaeon Sulfolobus solfataricus: eukaryotic features but bacterial route.

    abstract::The formation of the translation initiation complex represents the rate-limiting step in protein synthesis. Translation initiation in the crenarchaeon Sulfolobus solfataricus depends on several translation IFs (initiation factors), some of which have eukaryal but no bacterial counterparts. In the present paper, we rev...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20120300

    authors: La Teana A,Benelli D,Londei P,Bläsi U

    更新日期:2013-02-01 00:00:00

  • Peroxisomal ABC transporters: functions and mechanism.

    abstract::Peroxisomes are arguably the most biochemically versatile of all eukaryotic organelles. Their metabolic functions vary between different organisms, between different tissue types of the same organism and even between different developmental stages or in response to changed environmental conditions. New functions for p...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20150127

    authors: Baker A,Carrier DJ,Schaedler T,Waterham HR,van Roermund CW,Theodoulou FL

    更新日期:2015-10-01 00:00:00