Novel approach to design an isosteric charge-deficient analogue of spermine and its biochemically important derivatives.

Abstract:

:The design and synthesis of SpmTrien (1,12-diamino-3,6,9-triazadodecane), an isosteric and charge-deficient analogue of spermine with excellent chelating properties towards Cu(2+) ions, as well as novel N(1)- and N(12)-Ac-SpmTriens and bis-Et-SpmTrien (N(1),N(12)-diethyl-1,12-diamino-3,6,9-triazadodecane) are described. Possible applications of SpmTrien and its derivatives to the investigation of the enzymes of polyamine metabolism and spermine cellular functions, including interaction with DNA, are discussed.

journal_name

Biochem Soc Trans

authors

Khomutov AR,Grigorenko NA,Skuridin SG

doi

10.1042/BST0350369

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

369-73

issue

Pt 2

eissn

0300-5127

issn

1470-8752

pii

BST0350369

journal_volume

35

pub_type

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