Abstract:
:The design and synthesis of SpmTrien (1,12-diamino-3,6,9-triazadodecane), an isosteric and charge-deficient analogue of spermine with excellent chelating properties towards Cu(2+) ions, as well as novel N(1)- and N(12)-Ac-SpmTriens and bis-Et-SpmTrien (N(1),N(12)-diethyl-1,12-diamino-3,6,9-triazadodecane) are described. Possible applications of SpmTrien and its derivatives to the investigation of the enzymes of polyamine metabolism and spermine cellular functions, including interaction with DNA, are discussed.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Khomutov AR,Grigorenko NA,Skuridin SGdoi
10.1042/BST0350369subject
Has Abstractpub_date
2007-04-01 00:00:00pages
369-73issue
Pt 2eissn
0300-5127issn
1470-8752pii
BST0350369journal_volume
35pub_type
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