The molecular basis of the high linoleic acid content in Petunia seed oil: analysis of a seed-specific linoleic acid mutant.

abstract：:Recently, there have been significant advancements in dynamic-mode atomic force microscopy (AFM) for biological applications. With frequency modulation AFM (FM-AFM), subnanometer-scale surface structures of biomolecules such as secondary structures of proteins, phosphate groups of DNAs, and lipid-ion complexes have be...

journal_title：Biochemical Society transactions

authors： Fukuma T

更新日期：2020-08-28 00:00:00

abstract：:CYP74C3 (cytochrome P450 subfamily 74C3), an HPL (hydroperoxide lyase) from Medicago truncatula (barrel medic), and CYP74A1, an AOS (allene oxide synthase) from Arabidopsis thaliana, are key membrane-associated P450 enzymes in plant oxylipin metabolism. Both recombinant detergent-free enzymes are monomeric proteins wi...

journal_title：Biochemical Society transactions

authors： Hughes RK,Belfield EJ,Casey R

更新日期：2006-12-01 00:00:00

abstract：:The methyl-CpG-binding protein MeCP2 was discovered over 15 years ago as part of a search for proteins that selectively bind methylated DNA. It is a nuclear protein that is largely chromatin-bound and has a strong preference for binding to methylated DNA sequences in vivo. Evidence from model systems shows that MeCP2 ...

journal_title：Biochemical Society transactions

authors： Bird A

更新日期：2008-08-01 00:00:00

abstract：:Data from experimental studies in animals and from epidemiological studies in humans suggest a link between insulin and cognitive performance. Do these results translate into clinical and therapeutic benefit for people with cognitive impairment? Insulin injected peripherally can readily cross the blood-brain barrier. ...

journal_title：Biochemical Society transactions

authors： Strachan MW

更新日期：2005-11-01 00:00:00

abstract：:The n-6 polyunsaturated fatty acid, arachidonic acid, is a precursor of prostaglandins, leukotrienes and related compounds that have important roles as mediators and regulators of inflammation. Consuming increased amounts of long chain n-3 polyunsaturated fatty acids (found in oily fish and fish oils) results in a par...

journal_title：Biochemical Society transactions

authors： Calder PC

更新日期：2005-04-01 00:00:00

abstract：:Actin polymerization is harnessed by cells to generate lamellipodia for movement and by a subclass of pathogens to facilitate invasion of their infected hosts. Using electron tomography (ET), we have shown that lamellipodia are formed via the generation of subsets of actin filaments joined by branch junctions. Image a...

journal_title：Biochemical Society transactions

authors： Small JV

更新日期：2015-02-01 00:00:00

abstract：:Delineating the molecular pathways underlying seizure-induced neuronal death may yield novel strategies for brain protection against prolonged or repetitive seizures. Glutamate-mediated excitotoxicity and necrosis is a primary contributing mechanism but seizures also activate programmed (apoptotic) cell death pathways...

journal_title：Biochemical Society transactions

authors： Henshall DC

更新日期：2007-04-01 00:00:00

abstract：:The deposition of protein aggregates in various parts of our body gives rise to several devastating diseases, and the development of probes for the selective detection of aggregated proteins is crucial to advance our understanding of the pathogenesis underlying these diseases. LCPs (luminescent conjugated polythiophen...

journal_title：Biochemical Society transactions

authors： Klingstedt T,Nilsson KP

更新日期：2012-08-01 00:00:00

abstract：:The completely sequenced genome of the cyanobacterium Synechocystis PCC 6803 contains several open reading frames, of which the deduced amino acid sequences show similarities to proteins known to be involved in FeS cluster synthesis of nitrogenase (Nif proteins) and other FeS proteins (Isc proteins). In this article, ...

journal_title：Biochemical Society transactions

authors： Seidler A,Jaschkowitz K,Wollenberg M

更新日期：2001-08-01 00:00:00

abstract：:The phototrophic bacterium Rhodobacter capsulatus E1F1 assimilates nitrate under anaerobic phototrophic growth conditions. A 17 kb DNA region encoding the nitrate assimilation (nas) system of this bacterium has been cloned and sequenced. This region includes the genes coding for a putative ABC (ATP-binding cassette)-t...

journal_title：Biochemical Society transactions

authors： Pino C,Olmo-Mira F,Cabello P,Martínez-Luque M,Castillo F,Roldán MD,Moreno-Vivián C

更新日期：2006-02-01 00:00:00

abstract：:TDP-43 (TAR DNA-binding protein 43) is an hnRNP (heterogeneous nuclear ribonucleoprotein) protein whose role in cellular processes has come to the forefront of neurodegeneration research after the observation that it is the main component of brain inclusions in ALS (amyotrophic lateral sclerosis) and FTLD (frontotempo...

journal_title：Biochemical Society transactions

authors： Baralle M,Buratti E,Baralle FE

更新日期：2013-12-01 00:00:00

abstract：:In the amyloidogenic pathway, the APP (amyloid precursor protein) is proteolytically processed by the beta- and gamma-secretases to release the Abeta (amyloid-beta) peptide that is neurotoxic and aggregates in the brains of patients suffering from Alzheimer's disease. In the non-amyloidogenic pathway, APP is cleaved b...

journal_title：Biochemical Society transactions

authors： Hooper NM

更新日期：2005-04-01 00:00:00

abstract：:Effective stroke therapies require recanalization of occluded cerebral blood vessels; however, early reperfusion can cause BBB (blood-brain barrier) injury, leading to cerebral oedema and/or devastating brain haemorrhage. These complications of early reperfusion, which result from excess production of ROS (reactive ox...

journal_title：Biochemical Society transactions

authors： Maier CM,Hsieh L,Crandall T,Narasimhan P,Chan PH

更新日期：2006-12-01 00:00:00

abstract：:The membranes of living cells have been shown to be highly organized into distinct microdomains, which has spatial and temporal consequences for the interaction of membrane bound receptors and their signalling partners as complexes. Fluorescence correlation spectroscopy (FCS) is a technique with single cell sensitivit...

journal_title：Biochemical Society transactions

authors： Kilpatrick LE,Hill SJ

更新日期：2016-04-15 00:00:00

abstract：:An important aspect of the cytochrome c electrochemistry is the possibility of coupling the 'heterogeneous reactions' with other redox enzymes. Cellobiose dehydrogenase, a 89170 Da glycoprotein that contains both FAD and a b-type haem as prosthetic groups, donates electrons to a number of acceptors, including cytochro...

journal_title：Biochemical Society transactions

authors： Fridman V,Wollenberger U,Bogdanovskaya V,Lisdat F,Ruzgas T,Lindgren A,Gorton L,Scheller FW

更新日期：2000-02-01 00:00:00

abstract：:PilZ domain-containing proteins constitute a large family of bacterial signaling proteins. As a widely distributed protein domain for the binding of the second messenger c-di-GMP, the canonical PilZ domain contains a set of motifs that define the binding site for c-di-GMP and an allosteric switch for propagating local...

journal_title：Biochemical Society transactions

authors： Cheang QW,Xin L,Chea RYF,Liang ZX

更新日期：2019-02-28 00:00:00

abstract：:Besides stomata, the photosynthetic CO2 pathway also involves the transport of CO2 from the sub-stomatal air spaces inside to the carboxylation sites in the chloroplast stroma, where Rubisco is located. This pathway is far to be a simple and direct way, formed by series of consecutive barriers that the CO2 should cros...

journal_title：Biochemical Society transactions

authors： Gago J,Daloso DM,Carriquí M,Nadal M,Morales M,Araújo WL,Nunes-Nesi A,Flexas J

更新日期：2020-04-29 00:00:00

abstract：:Molecular bioenergetics deals with the construction, function and regulation of the powerhouses of life. The present overview sketches scenes and actors, farsighted goals and daring hypotheses, meticulous tool-making, painstaking benchwork, lucky discovery, serious scepticism, emphatic believing and strong characters ...

journal_title：Biochemical Society transactions

authors： Junge W

更新日期：2013-10-01 00:00:00

abstract：:Phagocytosis and phagosome maturation are crucial processes in biology. Phagocytosis and the subsequent digestion of phagocytosed particles occur across a huge diversity of eukaryotes and can be achieved by many different cells within one organism. In parallel, diverse groups of pathogens have evolved mechanisms to av...

journal_title：Biochemical Society transactions

authors： Smith LM,May RC

更新日期：2013-04-01 00:00:00

abstract：:Glyoxals are reactive alpha-oxoaldehydes that are formed endogenously from sugars, the levels of which are increased in various pathological conditions associated with hyperglycaemia and thiamine deficiency. However, the molecular cytotoxic mechanisms of glyoxal are not known. Results presented here and in the other s...

journal_title：Biochemical Society transactions

authors： Shangari N,Bruce WR,Poon R,O'Brien PJ

更新日期：2003-12-01 00:00:00

abstract：:The collagens of vertebrates may be divided into three groups according to chain size and whether or not the helical domains are continuous. Present evidence suggests that, at least within one of these groups, similarity between collagens is reflected in the organization of the genes that encode them. Early evidence s...

journal_title：Biochemical Society transactions

authors： Dalgleish R

更新日期：1988-10-01 00:00:00

abstract：:The evolution of proteins is inseparably linked to their function. Because most biological processes involve a number of different proteins, it may become impossible to study the evolutionary properties of proteins in isolation. In the present article, we show how simple mechanistic models of biological processes can ...

journal_title：Biochemical Society transactions

authors： Huvet M,Toni T,Tan H,Jovanovic G,Engl C,Buck M,Stumpf MP

更新日期：2009-08-01 00:00:00

abstract：:An RNA world has been placed centre stage for explaining the origin of life. Indeed, RNA is the most plausible molecule able to form both a (self)-replicator and to inherit information, necessities for initiating genetics. However, in parallel with self-replication, the proto-organism had to obtain the ability to cata...

journal_title：Biochemical Society transactions

authors： Ralser M

更新日期：2014-08-01 00:00:00

abstract：:Human adipose tissue has an important protein secretory function. Cytokines, hormones, prohormones and enzymes are secreted from fat cells and act in an endocrine or paracrine fashion. The production of several of these proteins is affected by obesity; normally there is an increase in the obese state. Protein producti...

journal_title：Biochemical Society transactions

authors： Arner P

更新日期：2001-05-01 00:00:00

abstract：:The design and synthesis of SpmTrien (1,12-diamino-3,6,9-triazadodecane), an isosteric and charge-deficient analogue of spermine with excellent chelating properties towards Cu(2+) ions, as well as novel N(1)- and N(12)-Ac-SpmTriens and bis-Et-SpmTrien (N(1),N(12)-diethyl-1,12-diamino-3,6,9-triazadodecane) are describe...

journal_title：Biochemical Society transactions

authors： Khomutov AR,Grigorenko NA,Skuridin SG

更新日期：2007-04-01 00:00:00

abstract：:The free energy landscape can provide a quantitative description of folding dynamics, if determined as a function of an optimally chosen reaction coordinate. The profile together with the optimal coordinate allows one to directly determine such basic properties of folding dynamics as the configurations of the minima a...

journal_title：Biochemical Society transactions

authors： Banushkina PV,Krivov SV

更新日期：2015-04-01 00:00:00

abstract：:RNase A (1 mM) was incubated with glucose (0.4 M) at 37 degrees C for up to 14 days in phosphate buffer (0.2 M, pH 7.4), digested with trypsin and analysed by LC-MS. The major sites of fructoselysine formation were Lys(1), Lys(7), Lys(37) and Lys(41). Three of these sites (Lys(7), Lys(37) and Lys(41)) were also the ma...

journal_title：Biochemical Society transactions

authors： Cotham WE,Hinton DJ,Metz TO,Brock JW,Thorpe SR,Baynes JW,Ames JM

更新日期：2003-12-01 00:00:00

abstract：:Intracellular pathogens survive in eukaryotic cells by evading a variety of host defences. To avoid degradation through the endocytic pathway, intracellular bacteria must adapt their phagosomes into protective compartments that promote bacterial replication. Legionella pneumophila and Coxiella burnetii are Gram-negati...

journal_title：Biochemical Society transactions

authors： Hardiman CA,McDonough JA,Newton HJ,Roy CR

更新日期：2012-12-01 00:00:00

abstract：:Inorganic polyphosphate (polyP) is found in all living organisms. The known polyP functions in eukaryotes range from osmoregulation and virulence in parasitic protozoa to modulating blood coagulation, inflammation, bone mineralization and cellular signalling in mammals. However mechanisms of regulation and even the id...

journal_title：Biochemical Society transactions

authors： Gerasimaitė R,Mayer A

更新日期：2016-02-01 00:00:00

abstract：:Starting shortly after parturition, and continuing throughout our lifetime, the gut microbiota coevolves with our metabolic and neurological programming. This symbiosis is regulated by a complex interplay between the host and environmental factors, including diet and lifestyle. Not surprisingly, the development of thi...

journal_title：Biochemical Society transactions

authors： Chambers SA,Townsend SD

更新日期：2020-06-29 00:00:00