The role of Rab GTPases in the transport of vacuoles containing Legionella pneumophila and Coxiella burnetii.

abstract：:The XMAP215 (Xenopus microtubule-associated protein 215) and CLASP [CLIP-170 (cytoskeletal linker protein 170) associated protein] microtubule plus end tracking families play central roles in the regulation of interphase microtubule dynamics and the proper formation of mitotic spindle architecture and flux. XMAP215 me...

journal_title：Biochemical Society transactions

authors： Slep KC

更新日期：2009-10-01 00:00:00

abstract：:Glyoxalase I is part of the glyoxalase system present in the cytosol of cells. The glyoxalase system catalyses the conversion of reactive, acyclic alpha-oxoaldehydes into the corresponding alpha-hydroxyacids. Glyoxalase I catalyses the isomerization of the hemithioacetal, formed spontaneously from alpha-oxoaldehyde an...

journal_title：Biochemical Society transactions

authors： Thornalley PJ

更新日期：2003-12-01 00:00:00

abstract：:This article reviews the progress of a personal endeavour to develop chromatography as a quantitative procedure for the determination of reaction stoichiometries and equilibrium constants governing protein interactions. As well as affording insight into an aspect of chromatography with which many protein chemists are ...

journal_title：Biochemical Society transactions

authors： Winzor DJ

更新日期：2003-10-01 00:00:00

abstract：:Sorting of activated epidermal growth factor receptor (EGFR) into intraluminal vesicles (ILVs) within the multivesicular body (MVB) is an essential step during the down-regulation of the receptor. The machinery that drives EGFR sorting attaches to the cytoplasmic face of the endosome and generates vesicles that bud in...

journal_title：Biochemical Society transactions

authors： Tabernero L,Woodman P

更新日期：2018-10-19 00:00:00

abstract：:The advantages of Hansenula polymorpha as a new yeast expression system are discussed in terms of the powerful and regulatable methanol oxidase promoter and the organism's ability to grow on cheap carbon sources. The development of techniques for conventional genetic analysis is described. A total of 218 mutants have ...

journal_title：Biochemical Society transactions

authors： Sudbery PE,Gleeson MA,Veale RA,Ledeboer AM,Zoetmulder MC

更新日期：1988-12-01 00:00:00

abstract：:Growing evidence supports the view that LDs (lipid droplets) are dynamic organelles that can serve both as an intracellular signalling compartment and as an organizing platform orchestrating many vital processes in eukaryotic cells. It has become clear that the LDs-confined deposition and lipolytic degradation of neut...

journal_title：Biochemical Society transactions

authors： Goldberg AA,Bourque SD,Kyryakov P,Boukh-Viner T,Gregg C,Beach A,Burstein MT,Machkalyan G,Richard V,Rampersad S,Titorenko VI

更新日期：2009-10-01 00:00:00

abstract：:The 'fusion peptides' of a group of enveloped viruses that includes influenza, paramyxo-, retro-and filo-viruses are N-terminal regions of their membrane fusion proteins generated by cleavage of non-functional precursors. For the influenza membrane fusion protein, haemagglutinin (HA), the three-dimensional structures ...

journal_title：Biochemical Society transactions

authors： Skehel JJ,Cross K,Steinhauer D,Wiley DC

更新日期：2001-08-01 00:00:00

abstract：:Leucine-rich repeat kinase 2 (LRRK2), a complex kinase/GTPase mutated in Parkinson's disease, has been shown to physically and functionally interact with cytoskeletal-related components in different brain cells. Neurons greatly rely on a functional cytoskeleton for many homeostatic processes such as local and long-dis...

journal_title：Biochemical Society transactions

authors： Civiero L,Cogo S,Biosa A,Greggio E

更新日期：2018-12-17 00:00:00

abstract：:Cultured pluripotent stem cells hold great promise for regenerative medicine. Considerable efforts have been invested into the refinement and definition of improved culture systems that sustain self-renewal and avoid differentiation of pluripotent cells in vitro. Recent studies have, however, found that the choice of ...

journal_title：Biochemical Society transactions

authors： McEwen KR,Leitch HG,Amouroux R,Hajkova P

更新日期：2013-06-01 00:00:00

abstract：:Many proteins self-assemble to form large supramolecular complexes. Numerous examples of these structures have been characterized, ranging from spherical viruses to tubular protein assemblies. Some new kinds of supramolecular structures are just coming to light, while it is likely there are others that have not yet be...

journal_title：Biochemical Society transactions

authors： Yeates TO,Tsai Y,Tanaka S,Sawaya MR,Kerfeld CA

更新日期：2007-06-01 00:00:00

abstract：:Dynein is an AAA+ (ATPase associated with various cellular activities)-type motor complex that utilizes ATP hydrolysis to actively drive microtubule sliding. The dynein heavy chain (molecular mass >500 kDa) contains six tandemly linked AAA+ modules and exhibits full motor activities. Detailed molecular dissection of t...

journal_title：Biochemical Society transactions

authors： Numata N,Kon T,Shima T,Imamula K,Mogami T,Ohkura R,Sutoh K,Sutoh K

更新日期：2008-02-01 00:00:00

abstract：:The steroid hormone progesterone regulates many critical aspects of vertebrate physiology. The nuclear receptor for progesterone functions as a ligand-activated transcription factor, directly regulating gene expression. This type of signalling is referred to as the 'genomic' pathway. Nevertheless, progesterone also st...

journal_title：Biochemical Society transactions

authors： Moussatche P,Lyons TJ

更新日期：2012-02-01 00:00:00

abstract：:Sensing and signalling events that detect abiotic stress-induced changes in plant water status and initiate downstream stress responses such as ABA (abscisic acid) accumulation and osmoregulation remain uncharacterized in plants. Although conclusive results are lacking, recent results from plants, and analogies to sig...

journal_title：Biochemical Society transactions

authors： Verslues PE,Zhu JK

更新日期：2005-04-01 00:00:00

abstract：:The Wilms' tumour-suppressor gene (WT1), encodes a zinc-finger transcription factor that is critical for the development of several organs, including the kidneys, gonads and spleen. Despite its identification as a tumour suppressor that plays a crucial role in the formation of a paediatric malignancy of the kidneys (W...

journal_title：Biochemical Society transactions

authors： Hartkamp J,Roberts SG

更新日期：2008-08-01 00:00:00

abstract：:Tribbles (TRIB) proteins are pseudokinase mediators of eukaryotic signalling that have evolved important roles in lipoprotein metabolism, immune function and cellular differentiation and proliferation. In addition, an evolutionary-conserved modulation of PI3K/AKT signalling pathways highlights them as novel and rather...

journal_title：Biochemical Society transactions

authors： Foulkes DM,Byrne DP,Bailey FP,Eyers PA

更新日期：2015-10-01 00:00:00

abstract：:GPCRs (G-protein-coupled receptors) are a large family of structurally related proteins, which mediate their effects by coupling with G-proteins. Despite responding to a range of very diverse stimuli, these receptors exhibit a conserved tertiary structure comprising a bundle of seven TM (transmembrane) helices linked ...

journal_title：Biochemical Society transactions

authors： Lawson Z,Wheatley M

更新日期：2004-12-01 00:00:00

abstract：:The inositol-depletion hypothesis was suggested to explain the therapeutic mechanism of mood-stabilizing drugs. Focus was previously on the phosphatidylinositol signalling pathway and on the regulatory roles of Ins(3,4,5)P(3) and DAG (diacylglycerol). Recent findings indicate that inositol and inositol-containing mole...

journal_title：Biochemical Society transactions

authors： Deranieh RM,Greenberg ML

更新日期：2009-10-01 00:00:00

abstract：:In interphase plant cells, the actin cytoskeleton is essential for intracellular transport and organization. To fully understand how the actin cytoskeleton functions as the structural basis for cytoplasmic organization, both molecular and physical aspects of the actin organization have to be considered. In the present...

journal_title：Biochemical Society transactions

authors： Ketelaar T,van der Honing HS,Emons AM

更新日期：2010-06-01 00:00:00

abstract：:PilZ domain-containing proteins constitute a large family of bacterial signaling proteins. As a widely distributed protein domain for the binding of the second messenger c-di-GMP, the canonical PilZ domain contains a set of motifs that define the binding site for c-di-GMP and an allosteric switch for propagating local...

journal_title：Biochemical Society transactions

authors： Cheang QW,Xin L,Chea RYF,Liang ZX

更新日期：2019-02-28 00:00:00

abstract：:Photosynthesis is fundamental to biomass production, but is a dynamic process sensitive to environmental constraints. In recent years, approaches to increase biomass and grain yield by altering photosynthetically related processes in the plant have received considerable attention. However, improving biomass yield requ...

journal_title：Biochemical Society transactions

authors： Heyneke E,Fernie AR

更新日期：2018-04-17 00:00:00

abstract：:Malaria during pregnancy is caused when parasite-infected erythrocytes accumulate within the placenta through interactions between the VAR2CSA protein on the infected erythrocyte surface and placental CSPGs (chondroitin sulfate proteoglycans). This interaction is the major target for therapeutics to treat or prevent p...

journal_title：Biochemical Society transactions

authors： Khunrae P,Higgins MK

更新日期：2010-10-01 00:00:00

abstract：:The most striking example of a complex prokaryotic intracytoplasmic organization can be found in the members of the phylum Planctomycetes. Among them are the anammox (anaerobic ammonium-oxidizing) bacteria, which possess a unique cell compartment with an unprecedented function in bacteria: the anammoxosome is a prokar...

journal_title：Biochemical Society transactions

authors： Neumann S,Jetten MS,van Niftrik L

更新日期：2011-12-01 00:00:00

abstract：:Targeting of protein kinases and phosphatases to the cytoskeleton enhances the regulation of many signalling events. Cytoskeletal signalling complexes facilitate this process by optimizing the relay of messages from membrane receptors to specific sites on the actin cytoskeleton. These signals influence fundamental cel...

journal_title：Biochemical Society transactions

authors： Scott JD

更新日期：2003-02-01 00:00:00

abstract：:The axial ligand of the catalytic mononuclear T1 copper site (Met(502)) of the CotA laccase was replaced by a leucine or phenylalanine residue to increase the redox potential of the enzyme. These mutations led to an increase in the redox potential by approx. 100 mV relative to the wild-type enzyme but the catalytic co...

journal_title：Biochemical Society transactions

authors： Melo EP,Fernandes AT,Durão P,Martins LO

更新日期：2007-12-01 00:00:00

abstract：:The thermoacidophile crenarchaeote Sulfolobus ssp. is one of the best-studied Archaea. Cryptic and conjugative plasmids as well as viruses have been described for this genus. For the majority of the genetic elements only the genome sequence and the basic characteristics were determined. In contrast the fusellovirus SS...

journal_title：Biochemical Society transactions

authors： Lipps G

更新日期：2004-04-01 00:00:00

abstract：:Molecular dynamics simulations may be used to probe the interactions of membrane proteins with lipids and with detergents at atomic resolution. Examples of such simulations for ion channels and for bacterial outer membrane proteins are described. Comparison of simulations of KcsA (an alpha-helical bundle) and OmpA (a ...

journal_title：Biochemical Society transactions

authors： Sansom MS,Bond PJ,Deol SS,Grottesi A,Haider S,Sands ZA

更新日期：2005-11-01 00:00:00

abstract：:Similar changes in glycosylation occur in the colonic epithelium in inflammatory conditions such as ulcerative colitis and Crohn's disease and also in colon cancer and precancerous adenomatous polyps. They include reduced length of O-glycans, reduced sulfation, increased sialylation and increased expression of oncofet...

journal_title：Biochemical Society transactions

authors： Rhodes JM,Campbell BJ,Yu LG

更新日期：2008-12-01 00:00:00

abstract：:The recruitment of the furanosidic scaffold of ribose as the crucial step for nucleotides and then for nucleic acids synthesis is presented. Based on the view that the selection of molecules to be used for relevant metabolic purposes must favor structurally well-defined molecules, the inadequacy of ribose as a prefere...

journal_title：Biochemical Society transactions

authors： Del-Corso A,Cappiello M,Moschini R,Balestri F,Mura U,Ipata PL

更新日期：2019-12-20 00:00:00

abstract：:The glutamate/aspartate transporter GLAST-1 is expressed in bone in vivo and also exists as a splice variant (GLAST-1a) in which exon 3 is excluded. Since GLAST-1 expression is regulated in bone in response to osteogenic mechanical stimuli in vivo and binding of glutamate to receptors on osteoblasts increases osteobla...

journal_title：Biochemical Society transactions

authors： Huggett JF,Mustafa A,O'neal L,Mason DJ

更新日期：2002-11-01 00:00:00

abstract：:[Ca(2+)](i) (intracellular Ca(2+) concentration) oscillations play a central role in the activation of T-lymphocytes by antigen. Oscillations in T-cells are absolutely dependent on Ca(2+) influx through store-operated CRAC channels (Ca(2+)-release-activated Ca(2+) channels), and evidence suggests that they arise from ...

journal_title：Biochemical Society transactions

authors： Lewis RS

更新日期：2003-10-01 00:00:00