The role of TOG domains in microtubule plus end dynamics.

abstract：:The PI3K (phosphoinositide 3-kinase) family of lipid kinases regulate cell motility in diverse organisms and cell types. In mammals, the main PI3K enzyme activated by chemokine receptor signalling is the class IB isoform, p110gamma. Studies of p110gamma-knockout mice have shown an essential function for this isoform i...

journal_title：Biochemical Society transactions

authors： Oak JS,Matheu MP,Parker I,Cahalan MD,Fruman DA

更新日期：2007-11-01 00:00:00

abstract：:Classical tissue engineering is aimed mainly at producing anatomically and physiologically realistic replacements for normal human tissues. It is done either by encouraging cellular colonization of manufactured matrices or cellular recolonization of decellularized natural extracellular matrices from donor organs, or b...

journal_title：Biochemical Society transactions

authors： Davies JA,Cachat E

更新日期：2016-06-15 00:00:00

abstract：:HDX-MS has emerged as a powerful tool to interrogate the structure and dynamics of proteins and their complexes. Recent advances in the methodology and instrumentation have enabled the application of HDX-MS to membrane proteins. Such targets are challenging to investigate with conventional strategies. Developing new t...

journal_title：Biochemical Society transactions

authors： Lau AM,Jia R,Bradshaw RT,Politis A

更新日期：2020-06-29 00:00:00

abstract：:Shewanella oneidensis MR-1 is a sediment organism capable of dissimilatory reduction of insoluble metal compounds such as those of Fe(II) and Mn(IV). This bacterium has been used as a model organism for potential applications in bioremediation of contaminated environments and in the production of energy in microbial f...

journal_title：Biochemical Society transactions

authors： Louro RO,Paquete CM

更新日期：2012-12-01 00:00:00

abstract：:Colorectal cancer is the third most common cancer in developed countries such as the U.K., but incidence rates around the world vary approx. 20-fold. Diet is thought to be a key factor determining risk: red and processed meat, but not white meat or fish, are associated with an increased risk of colorectal cancer. The ...

journal_title：Biochemical Society transactions

authors： Kuhnle GG,Bingham SA

更新日期：2007-11-01 00:00:00

abstract：:A full picture of the similarities between Family A and Family B GPCRs (G-protein coupled receptors) has been frustrated by the lack of clear homology between the respective sequences. Here, we review previous computational studies on GPCR dimerization in which the putative dimerization interfaces have been analysed u...

journal_title：Biochemical Society transactions

authors： Vohra S,Chintapalli SV,Illingworth CJ,Reeves PJ,Mullineaux PM,Clark HS,Dean MK,Upton GJ,Reynolds CA

更新日期：2007-08-01 00:00:00

abstract：:The CPC (chromosomal passenger complex) performs essential roles in the regulation and co-ordination of chromosomal and cytoskeletal events during mitosis and meiosis. The first functional analyses showed evidence of a role of the CPC in the regulation of cytokinesis. In this review, I summarize what we have learned s...

journal_title：Biochemical Society transactions

authors： Carmena M

更新日期：2008-06-01 00:00:00

abstract：:One of the primary functions of AMP-activated protein kinase (AMPK) is to regulate the metabolic pathways in response to reduced cellular energy charge. Most of the known targets of the kinase are cytoplasmic enzymes involved in both catabolic and anabolic metabolism. In addition, activation of AMPK in many cells resu...

journal_title：Biochemical Society transactions

authors： Leff T

更新日期：2003-02-01 00:00:00

abstract：:AD (Alzheimer's disease) is a neurodegenerative disease characterized by a gradual loss of neurons and the accumulation of neurotoxic Aβ (amyloid β-peptide) and hyperphosphorylated tau. The discovery of mutations in three genes, PSEN1 (presenilin 1), PSEN2 (presenilin 2) and APP (amyloid precursor protein), in patient...

journal_title：Biochemical Society transactions

authors： Coen K,Annaert W

更新日期：2010-12-01 00:00:00

abstract：:Diet can significantly influence exercise performance. Diet alone will not ensure successful performance in sport, but it plays a permissive role in allowing sustained intensive training with limited risk of illness and injury. Diet may also promote adaptations to training by stimulating synthesis and breakdown of the...

journal_title：Biochemical Society transactions

authors： Maughan RJ

更新日期：2003-12-01 00:00:00

abstract：:The human prostate expresses very high concentrations of annexins 1, 4, and 5 and secretes high concentrations of annexins 1 and 5. Although the biological roles of these proteins in prostate secretions are not known, these studies emphasize the need to consider extracellular sites for physiological functions of annex...

journal_title：Biochemical Society transactions

authors： Haigler HT,Christmas P

更新日期：1990-12-01 00:00:00

abstract：:Senescence is a tumour suppressor mechanism which is cell-intrinsically activated in the context of cellular stress. Senescence can further be propagated to neighbouring cells, a process called secondary senescence induction. Secondary senescence was initially shown as a paracrine response to the secretion of cytokine...

journal_title：Biochemical Society transactions

authors： Kirschner K,Rattanavirotkul N,Quince MF,Chandra T

更新日期：2020-06-30 00:00:00

abstract：:Targeting of estrogen receptor is commonly used as a first-line treatment for hormone-positive breast cancer patients, and is considered as a keystone of systemic cancer therapy. Likewise, HER2-targeted therapy significantly improved the survival of HER2-positive breast cancer patients, indicating that targeted therap...

journal_title：Biochemical Society transactions

authors： Lev S

更新日期：2020-04-29 00:00:00

abstract：:Saccharomyces cerevisiae cells grown in glucose have larger average size than cells grown in ethanol. Besides, yeast must reach a carbon source-modulated critical cell size in order to enter S phase at Start. This control is of outmost physiological relevance, since it allows us to coordinate cell growth with cell cyc...

journal_title：Biochemical Society transactions

authors： Vanoni M,Rossi RL,Querin L,Zinzalla V,Alberghina L

更新日期：2005-02-01 00:00:00

abstract：:The short consensus/complement repeat (SCR) domain (also known as the complement control protein domain) is the most abundant domain type in the complement system. Crystal and NMR structures for proteins that contain single and multiple SCR domains have now been published. These contain inter-SCR linkers of between th...

journal_title：Biochemical Society transactions

authors： Perkins SJ,Gilbert HE,Aslam M,Hannan J,Holers VM,Goodship TH

更新日期：2002-11-01 00:00:00

abstract：:Seeds of rape (Brassica napus L.) were germinated at various NaCl concentrations up to 200 mM. Germinating levels, seedling growth, triacylglycerol mobilization and lipase activity were investigated. High salt concentrations resulted in retardation of seed germination. Seedling growth as measured by radicle length was...

journal_title：Biochemical Society transactions

authors： Ben Miled DD,Zarrouk M,Chérif A

更新日期：2000-12-01 00:00:00

abstract：:We study how mechanical forces integrate spatially and temporally with regulatory signals at the leading edge of migrating cells. To probe the dynamics of this system, we developed quantitative fluorescent speckle microscopy, which maps out actin cytoskeleton transport, assembly and disassembly with high spatial resol...

journal_title：Biochemical Society transactions

authors： Danuser G

更新日期：2005-12-01 00:00:00

abstract：:Numerous RNA molecules with new catalytic properties have been isolated from synthetic combinatorial libraries. A broad range of chemical reactions is catalysed, and nucleic acids can accelerate bond formation between small organic substrates. This review focuses on carbon-carbon bond formation accelerated by in vitro...

journal_title：Biochemical Society transactions

authors： Jäschke A,Stuhlmann F,Bebenroth D,Keiper S,Wombacher R

更新日期：2002-11-01 00:00:00

abstract：:The evolution of proteins is inseparably linked to their function. Because most biological processes involve a number of different proteins, it may become impossible to study the evolutionary properties of proteins in isolation. In the present article, we show how simple mechanistic models of biological processes can ...

journal_title：Biochemical Society transactions

authors： Huvet M,Toni T,Tan H,Jovanovic G,Engl C,Buck M,Stumpf MP

更新日期：2009-08-01 00:00:00

abstract：:African trypanosomes have plastic genomes with extensive variability at the chromosome ends. The genes encoding the expressed major surface protein of the infective bloodstream form stages of Trypanosoma brucei and are located at telomeres. These telomeric expression-site transcription units are turning out to be surp...

journal_title：Biochemical Society transactions

authors： Rudenko G

更新日期：2000-10-01 00:00:00

abstract：:Hsk1 (homologue of Cdc7 kinase 1) of the fission yeast is a member of the conserved Cdc7 (cell division cycle 7) kinase family, and promotes initiation of chromosome replication by phosphorylating Mcm (minichromosome maintenance) subunits, essential components for the replicative helicase. Recent studies, however, ind...

journal_title：Biochemical Society transactions

authors： Matsumoto S,Masai H

更新日期：2013-12-01 00:00:00

abstract：:Numerous bacterial proteins involved in the nitrogen cycle, and other processes, require c-type haem as a cofactor. c-type cytochromes are formed by covalent attachment of haem to the conserved CXXCH motif. Here, we briefly review what is presently known about cytochrome c maturation in Bacillus subtilis with particul...

journal_title：Biochemical Society transactions

authors： Crow A,Le Brun NE,Oubrie A

更新日期：2005-02-01 00:00:00

abstract：:Actin polymerization is harnessed by cells to generate lamellipodia for movement and by a subclass of pathogens to facilitate invasion of their infected hosts. Using electron tomography (ET), we have shown that lamellipodia are formed via the generation of subsets of actin filaments joined by branch junctions. Image a...

journal_title：Biochemical Society transactions

authors： Small JV

更新日期：2015-02-01 00:00:00

abstract：:In plant and metazoan, Polycomb Group (PcG) proteins play key roles in regulating developmental processes by repression of gene expression. PcG proteins function as multi-protein complexes; among them the best characterized ones are Polycomb Repressive Complex 1 (PRC1) and PRC2. PRC2 catalyzes histone H3 lysine 27 tri...

journal_title：Biochemical Society transactions

authors： Wang Q,Shen WH

更新日期：2018-08-20 00:00:00

abstract：:Protein L is a multidomain cell-wall protein isolated from Peptostreptococcus magnus. It belongs to a group of proteins that contain repeated domains that are able to bind to Igs without stimulating an immune response, the most characterized of this group being Protein A ( Staphylococcus aureus ) and Protein G ( Strep...

journal_title：Biochemical Society transactions

authors： Housden NG,Harrison S,Roberts SE,Beckingham JA,Graille M,Stura E,Gore MG

更新日期：2003-06-01 00:00:00

abstract：:The ribosome is the macromolecular machinery in the host cell for which all viruses have to compete. Early in infection, the viral mRNAs have to compete with the host for both the ribosomes and for the limited pool of eukaryotic initiation factors that are needed to facilitate the recruitment of ribosomes to both vira...

journal_title：Biochemical Society transactions

authors： Sarnow P,Cevallos RC,Jan E

更新日期：2005-12-01 00:00:00

abstract：:GRIF-1 [GABA(A) (gamma-aminobutyric acid(A)) receptor interacting factor-1] is a member of a coiled-coil family of proteins thought to function as adaptors in the anterograde trafficking of organelles utilizing the kinesin-1 motor proteins to synapses. To study in more detail the molecular interaction between GRIF-1 a...

journal_title：Biochemical Society transactions

authors： Pozo K,Stephenson FA

更新日期：2006-02-01 00:00:00

abstract：:Photoreaction centres are Nature's solar batteries. These nanometre-scale power producers are responsible for transducing the energy of sunlight into a form that can be used by biological systems, thereby powering most of the biological activity on the planet. Although to the layman the word 'photosynthesis' is usuall...

journal_title：Biochemical Society transactions

authors： Jones MR

更新日期：2009-04-01 00:00:00

abstract：:The adhesion of cells to the extracellular matrix is a dynamic process, mediated by a series of cell-surface and matrix-associated molecules that interact with each other in a spatially and temporally regulated manner. These interactions play a major role in tissue formation, cellular migration and the induction of ad...

journal_title：Biochemical Society transactions

authors： Zaidel-Bar R,Cohen M,Addadi L,Geiger B

更新日期：2004-06-01 00:00:00

abstract：:Unr (upstream of N-ras) is a eukaryotic RNA-binding protein that has a number of roles in the post-transcriptional regulation of gene expression. Originally identified as an activator of internal initiation of picornavirus translation, it has since been shown to act as an activator and inhibitor of cellular translatio...

journal_title：Biochemical Society transactions

authors： Ray S,Catnaigh PÓ,Anderson EC

更新日期：2015-06-01 00:00:00