Functional heterogeneity in senescence.

Abstract:

:Senescence is a tumour suppressor mechanism which is cell-intrinsically activated in the context of cellular stress. Senescence can further be propagated to neighbouring cells, a process called secondary senescence induction. Secondary senescence was initially shown as a paracrine response to the secretion of cytokines from primary senescent cells. More recently, juxtacrine Notch signalling has been implicated in mediating secondary senescence induction. Primary and secondary senescent induction results in distinct transcriptional outcomes. In addition, cell type and the stimulus in which senescence is induced can lead to variations in the phenotype of the senescence response. It is unclear whether heterogeneous senescent end-points are associated with distinct cellular function in situ, presenting functional heterogeneity. Thus, understanding senescence heterogeneity could prove to be important when devising ways of targeting senescent cells by senolytics, senostatics or senogenics. In this review, we discuss a role for functional heterogeneity in senescence in tissue- and cell-type specific manners, highlighting potential differences in senescence outcomes of primary and secondary senescence.

journal_name

Biochem Soc Trans

authors

Kirschner K,Rattanavirotkul N,Quince MF,Chandra T

doi

10.1042/BST20190109

subject

Has Abstract

pub_date

2020-06-30 00:00:00

pages

765-773

issue

3

eissn

0300-5127

issn

1470-8752

pii

223813

journal_volume

48

pub_type

杂志文章
  • Homomeric protein complexes: evolution and assembly.

    abstract::Homo-oligomeric protein complexes are functionally vital and highly abundant in living cells. In the present article, we review our current understanding of their geometry and evolution, including aspects of the symmetry of these complexes and their interaction interfaces. Also, we briefly discuss the pathway of their...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0380879

    authors: Venkatakrishnan AJ,Levy ED,Teichmann SA

    更新日期:2010-08-01 00:00:00

  • Critique of the demographic evidence for 'late-life non-senescence'.

    abstract::Although the Gompertz formula accurately describes observed mortality distributions over most of their extent, their 'tail' is much longer than that of a Gompertz curve fitted to the whole data set. A simple candidate explanation is that the longest-lived subset of any population will necessarily be enriched in indivi...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/bst0310452

    authors: de Grey AD

    更新日期:2003-04-01 00:00:00

  • Before and beyond ABA: upstream sensing and internal signals that determine ABA accumulation and response under abiotic stress.

    abstract::Sensing and signalling events that detect abiotic stress-induced changes in plant water status and initiate downstream stress responses such as ABA (abscisic acid) accumulation and osmoregulation remain uncharacterized in plants. Although conclusive results are lacking, recent results from plants, and analogies to sig...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0330375

    authors: Verslues PE,Zhu JK

    更新日期:2005-04-01 00:00:00

  • Compartmentalization of GPCR signalling controls unique cellular responses.

    abstract::With >800 members, G protein-coupled receptors (GPCRs) are the largest class of cell-surface signalling proteins, and their activation mediates diverse physiological processes. GPCRs are ubiquitously distributed across all cell types, involved in many diseases and are major drug targets. However, GPCR drug discovery i...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20150236

    authors: Ellisdon AM,Halls ML

    更新日期:2016-04-15 00:00:00

  • Chain reactions: molecular mechanisms of RBR ubiquitin ligases.

    abstract::Ubiquitination is a fundamental post-translational modification that regulates almost all aspects of cellular signalling and is ultimately catalysed by the action of E3 ubiquitin ligases. The RING-between-RING (RBR) family of E3 ligases encompasses 14 distinct human enzymes that are defined by a unique domain organisa...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20200237

    authors: Cotton TR,Lechtenberg BC

    更新日期:2020-08-28 00:00:00

  • Cross-talk between LRRK2 and PKA: implication for Parkinson's disease?

    abstract::Evidence indicates that leucine-rich repeat kinase 2 (LRRK2) controls multiple processes in neurons and glia cells. Deregulated LRRK2 activity due to gene mutation represents the most common cause of autosomal dominant Parkinson's disease (PD). Protein kinase A (PKA)-mediated signaling is a key regulator of brain func...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20160396

    authors: Greggio E,Bubacco L,Russo I

    更新日期:2017-02-08 00:00:00

  • Regulation of the pyruvate dehydrogenase complex.

    abstract::The PDC (pyruvate dehydrogenase complex) plays a central role in the maintenance of glucose homoeostasis in mammals. The carbon flux through the PDC is meticulously controlled by elaborate mechanisms involving post-translational (short-term) phosphorylation/dephosphorylation and transcriptional (long-term) controls. T...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20060217

    authors: Patel MS,Korotchkina LG

    更新日期:2006-04-01 00:00:00

  • Latherin and other biocompatible surfactant proteins.

    abstract::Horses and other equids are unusual in producing protein-rich sweat for thermoregulation, a major component of which is latherin, a highly surface-active, non-glycosylated protein that is a member of the PLUNC (palate, lung and nasal epithelium clone) family. Latherin produces a significant reduction in water surface ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0391017

    authors: Kennedy MW

    更新日期:2011-08-01 00:00:00

  • Structure and assembly of the spliceosomal snRNPs. Novartis Medal Lecture.

    abstract::The spliceosome is a macromolecular machine that carries out the excision of introns from eukaryotic pre-mRNAs and splicing together of exons. Four large RNA-protein complexes, called the U1, U2, U4/U6 and U5 small nuclear ribonucleoprotein particles (snRNPs), and some non-snRNP proteins assemble around three short co...

    journal_title:Biochemical Society transactions

    pub_type:

    doi:10.1042/0300-5127:0290015

    authors: Nagai K,Muto Y,Pomeranz Krummel DA,Kambach C,Ignjatovic T,Walke S,Kuglstatter A

    更新日期:2001-05-01 00:00:00

  • C/D box sRNA, CRISPR RNA and tRNA processing in an archaeon with a minimal fragmented genome.

    abstract::The analysis of deep sequencing data allows for a genome-wide overview of all the small RNA molecules (the 'sRNome') that are present in a single organism. In the present paper, we review the processing of CRISPR (clustered regularly interspaced short palindromic repeats) RNA, C/D box sRNA (small non-coding RNA) and t...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20120276

    authors: Richter H,Mohr S,Randau L

    更新日期:2013-02-01 00:00:00

  • Engineering tissue for the fetus: stem cells and matrix signalling.

    abstract::Congenital malformations are major causes of disease and death during the first years of life and, most of the time, functional replacement of the missing or damaged organs remains an unmet clinical need. Particularly relevant for the treatment of congenital malformation would be to collect the stem cells at diagnosis...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20140069

    authors: De Coppi P

    更新日期:2014-06-01 00:00:00

  • Study of prostaglandin receptors in mitochondria on apoptosis of human lung carcinoma cell line A549.

    abstract::PGs (prostaglandins) are synthesized through the cyclo-oxygenase (COX-1 and -2) pathway in a variety of cells in response to various physiological stimuli. All cells require at least one pathway for apoptosis, and mitochondrial play a central role in regulation of apoptosis. In a previous study, incubation of A549 cel...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0321078

    authors: Fang KM,Shu WH,Chang HC,Wang JJ,Mak OT

    更新日期:2004-12-01 00:00:00

  • Sodium chloride effects on lipase activity in germinating rape seeds.

    abstract::Seeds of rape (Brassica napus L.) were germinated at various NaCl concentrations up to 200 mM. Germinating levels, seedling growth, triacylglycerol mobilization and lipase activity were investigated. High salt concentrations resulted in retardation of seed germination. Seedling growth as measured by radicle length was...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:

    authors: Ben Miled DD,Zarrouk M,Chérif A

    更新日期:2000-12-01 00:00:00

  • Identifying plant cell-surface receptors: combining 'classical' techniques with novel methods.

    abstract::Cell-cell communication during development and reproduction in plants depends largely on a few phytohormones and many diverse classes of polymorphic secreted peptides. The peptide ligands are bound at the cell surface of target cells by their membranous interaction partners representing, in most cases, either receptor...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20130251

    authors: Uebler S,Dresselhaus T

    更新日期:2014-04-01 00:00:00

  • Mutations in genes encoding regulators of mRNA decapping and translation initiation: links to intellectual disability.

    abstract::Intellectual disability (ID) affects at least 1% of the population, and typically presents in the first few years of life. ID is characterized by impairments in cognition and adaptive behavior and is often accompanied by further delays in language and motor skills, as seen in many neurodevelopmental disorders (NDD). R...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20200109

    authors: Weil D,Piton A,Lessel D,Standart N

    更新日期:2020-06-30 00:00:00

  • Lack of TXNIP protects beta-cells against glucotoxicity.

    abstract::Glucotoxicity plays a major role in pancreatic beta-cell apoptosis and diabetes progression, but the factors involved have remained largely unknown. Our recent studies have identified TXNIP (thioredoxin-interacting protein) as a novel pro-apoptotic beta-cell factor that is induced by glucose, suggesting that TXNIP may...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0360963

    authors: Shalev A

    更新日期:2008-10-01 00:00:00

  • The nuclear receptor co-repressor RIP140 controls the expression of metabolic gene networks.

    abstract::NRs (nuclear receptors) regulate the expression of specific gene networks in target cells by recruiting cofactor complexes involved in chromatin remodelling and in the assembly of transcription complexes. The importance of activating gene expression, in metabolic tissues, is well established, but the contribution of t...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0341103

    authors: Parker MG,Christian M,White R

    更新日期:2006-12-01 00:00:00

  • Regulation of chromosome dynamics by Hsk1/Cdc7 kinase.

    abstract::Hsk1 (homologue of Cdc7 kinase 1) of the fission yeast is a member of the conserved Cdc7 (cell division cycle 7) kinase family, and promotes initiation of chromosome replication by phosphorylating Mcm (minichromosome maintenance) subunits, essential components for the replicative helicase. Recent studies, however, ind...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20130217

    authors: Matsumoto S,Masai H

    更新日期:2013-12-01 00:00:00

  • Oxidative modification of triacylglycerol-rich lipoproteins.

    abstract::Lipoprotein oxidation is thought to play a pivotal role in the evolution of atherosclerosis. Low-density lipoprotein (LDL) is the main source of oxidized lipid in the arterial wall. Oxidation of LDL alters its properties in a number of ways, making it more atherogenic, but oxidation of other lipoprotein classes may al...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0311062

    authors: Young IS,McFarlane C,McEneny J

    更新日期:2003-10-01 00:00:00

  • Crop reproductive meristems in the genomic era: a brief overview.

    abstract::Modulation of traits beneficial for cultivation and yield is one of the main goals of crop improvement. One of the targets for enhancing productivity is changing the architecture of inflorescences since in many species it determines fruit and seed yield. Inflorescence shape and organization is genetically established ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20190441

    authors: Caselli F,Zanarello F,Kater MM,Battaglia R,Gregis V

    更新日期:2020-06-30 00:00:00

  • Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies.

    abstract::JNK (c-Jun N-terminal kinase) is a member of the MAPK (mitogen-activated protein kinase) family that regulates a range of biological processes implicated in tumorigenesis and neurodegenerative disorders. For example, genetic studies have demonstrated that the removal of specific Jnk genes can reduce neuronal death ass...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20110641

    authors: Davies C,Tournier C

    更新日期:2012-02-01 00:00:00

  • The latex-fruit syndrome.

    abstract::Approximately 30-50% of individuals who are allergic to natural rubber latex (NRL) show an associated hypersensitivity to some plant-derived foods, especially freshly consumed fruits. This association of latex allergy and allergy to plant-derived foods is called latex-fruit syndrome. An increasing number of plant sour...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0300935

    authors: Wagner S,Breiteneder H

    更新日期:2002-11-01 00:00:00

  • Defining the roles and interactions of PTB.

    abstract::PTB (polypyrimidine tract-binding protein) is an abundant and widely expressed RNA-binding protein with four RRM (RNA recognition motif) domains. PTB is involved in numerous post-transcriptional steps in gene expression in both the nucleus and cytoplasm, but has been best characterized as a regulatory repressor of som...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20120044

    authors: Kafasla P,Mickleburgh I,Llorian M,Coelho M,Gooding C,Cherny D,Joshi A,Kotik-Kogan O,Curry S,Eperon IC,Jackson RJ,Smith CW

    更新日期:2012-08-01 00:00:00

  • New aspects in cardiac L-type Ca2+ channel regulation.

    abstract::Cardiac excitation-contraction coupling is initiated with the influx of Ca2+ ions across the plasma membrane through voltage-gated L-type calcium channels. This process is tightly regulated by modulation of the channel open probability and channel localization. Protein kinase A (PKA) is found in close association with...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20190229

    authors: Pallien T,Klussmann E

    更新日期:2020-02-28 00:00:00

  • Red, yellow, green go!--A novel tool for microscopic segregation of secretory vesicle pools according to their age.

    abstract::Large dense-core vesicles (LDCVs) were labelled in cultured bovine adrenal chromaffin cells expressing fluorescent chimaeric 'cargo' proteins that were targeted to these secretory vesicles. When the cells were stimulated with nicotine 48 h after transduction, the fractional loss of fluorescent LDCVs was much greater t...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0310851

    authors: Wiegand UK,Duncan RR,Greaves J,Chow RH,Shipston MJ,Apps DK

    更新日期:2003-08-01 00:00:00

  • Functions of the nuclear envelope and lamina in development and disease.

    abstract::Recent findings that some 24 inherited diseases and anomalies are caused by defects in proteins of the NE (nuclear envelope) and lamina have resulted in a fundamental reassessment of the functions of the NE and underlying lamina. Instead of just regarding the NE and lamina as a molecular filtering device, regulating t...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0361329

    authors: Cohen TV,Hernandez L,Stewart CL

    更新日期:2008-12-01 00:00:00

  • Specificity and selectivity in post-translational biotin addition.

    abstract::Biotin, which serves as a carboxyl group carrier in reactions catalyzed by biotin-dependent carboxylases, is essential for life in most organisms. To function in carboxylate transfer, the vitamin must be post-translationally linked to a specific lysine residue on the biotin carboxyl carrier (BCC) of a carboxylase in a...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20180425

    authors: Beckett D

    更新日期:2018-12-17 00:00:00

  • Dissecting metabolism using zebrafish models of disease.

    abstract::Zebrafish (Danio rerio) are becoming an increasingly powerful model organism to study the role of metabolism in disease. Since its inception, the zebrafish model has relied on unique attributes such as the transparency of embryos, high fecundity and conservation with higher vertebrates, to perform phenotype-driven che...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20180335

    authors: Salmi TM,Tan VWT,Cox AG

    更新日期:2019-02-28 00:00:00

  • Protein kinase C in cellular transformation: a valid target for therapy?

    abstract::The protein kinase C (PKC) family of serine/threonine protein kinases share structural homology, while exhibiting substantial functional diversity. PKC isoforms are ubiquitously expressed in tissues which makes it difficult to define roles for individual isoforms, with complexity compounded by the finding that PKC iso...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20140255

    authors: Tarafdar A,Michie AM

    更新日期:2014-12-01 00:00:00

  • Atomic force microscopy of virus shells.

    abstract::Microscopes are used to characterize small objects with the help of probes that interact with the specimen, such as photons and electrons in optical and electron microscopies, respectively. In atomic force microscopy (AFM), the probe is a nanometric tip located at the end of a microcantilever which palpates the specim...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20160316

    authors: Moreno-Madrid F,Martín-González N,Llauró A,Ortega-Esteban A,Hernando-Pérez M,Douglas T,Schaap IA,de Pablo PJ

    更新日期:2017-04-15 00:00:00