Abstract:
:One of the primary functions of AMP-activated protein kinase (AMPK) is to regulate the metabolic pathways in response to reduced cellular energy charge. Most of the known targets of the kinase are cytoplasmic enzymes involved in both catabolic and anabolic metabolism. In addition, activation of AMPK in many cells results in changes in the pattern of gene expression. Although some of these effects are undoubtedly secondary responses to modified cellular metabolism, it is possible that in addition to its well-characterized function in the cytoplasm, AMPK also directly phosphorylates and regulates proteins involved in gene transcription. There are now several examples of transcription factors, cofactors and components of the transcriptional core machinery that are directly phosphorylated and regulated by AMPK. Here I review these examples and discuss the significance of AMPK activity in the nucleus.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Leff Tdoi
10.1042/bst0310224keywords:
subject
Has Abstractpub_date
2003-02-01 00:00:00pages
224-7issue
Pt 1eissn
0300-5127issn
1470-8752journal_volume
31pub_type
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