Abstract:
:Microvesicles are shed constitutively, or upon activation, from both normal and malignant cells. The process is dependent on an increase in cytosolic Ca2+, which activates different enzymes, resulting in depolymerization of the actin cytoskeleton and release of the vesicles. Drug resistance can be defined as the ability of cancer cells to survive exposure to a wide range of anti-cancer drugs, and anti-tumour chemotherapeutic treatments are often impaired by innate or acquired MDR (multidrug resistance). Microvesicles released upon chemotherapeutic agents prevent the drugs from reaching their targets and also mediate intercellular transport of MDR proteins.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Jorfi S,Inal JMdoi
10.1042/BST20120273subject
Has Abstractpub_date
2013-02-01 00:00:00pages
293-8issue
1eissn
0300-5127issn
1470-8752pii
BST20120273journal_volume
41pub_type
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
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journal_title:Biochemical Society transactions
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journal_title:Biochemical Society transactions
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更新日期:2004-12-01 00:00:00
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journal_title:Biochemical Society transactions
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doi:10.1042/BST0381037
更新日期:2010-08-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST0371423
更新日期:2009-12-01 00:00:00
abstract::The Drosophila melanogaster flightless I protein and its homologues in higher eukaryotes (FliI) are conserved members of the gelsolin family of actin-binding proteins. Members of the gelsolin family generally contain three or six copies of a 125-amino-acid residue gelsolin-related repeating unit, and may contain addit...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2004-12-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST20130271
更新日期:2014-04-01 00:00:00
abstract::In T cell development, a pivotal decision-making stage, termed β-selection, integrates a TCRβ checkpoint to coordinate survival, proliferation and differentiation to an αβ T cell. Here, we review how transcriptional regulation coordinates fate determination in early T cell development to enable β-selection. Errors in ...
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pub_type: 杂志文章,评审
doi:10.1042/BST20180414
更新日期:2019-08-30 00:00:00
abstract::Prelamin A is the precursor protein of lamin A, a major constituent of the nuclear lamina in higher eukaryotes. Increasing attention to prelamin A processing and function has been given after the discovery, from 2002 to 2004, of diseases caused by prelamin A accumulation. These diseases, belonging to the group of lami...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST20110657
更新日期:2011-12-01 00:00:00
abstract::Hsk1 (homologue of Cdc7 kinase 1) of the fission yeast is a member of the conserved Cdc7 (cell division cycle 7) kinase family, and promotes initiation of chromosome replication by phosphorylating Mcm (minichromosome maintenance) subunits, essential components for the replicative helicase. Recent studies, however, ind...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST20130217
更新日期:2013-12-01 00:00:00
abstract::Abnormal protein aggregation and intracellular or extracellular accumulation of misfolded and aggregated proteins are key events in the pathogenesis of different neurodegenerative diseases. Furthermore, endoplasmic reticulum stress and impairment of the ubiquitin-proteasome system probably contribute to neurodegenerat...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0380150
更新日期:2010-02-01 00:00:00
abstract::TRP (transient receptor potential) channels comprise a superfamily of non-selective cation channels with at least seven subfamilies. The variety of subfamilies corresponds to the differences in the activation mechanisms and functions. TRPM3 (TRP melastatin 3) and TRPV4 (TRP vanilloid 3) have been characterized as cati...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0350091
更新日期:2007-02-01 00:00:00
abstract::Starting shortly after parturition, and continuing throughout our lifetime, the gut microbiota coevolves with our metabolic and neurological programming. This symbiosis is regulated by a complex interplay between the host and environmental factors, including diet and lifestyle. Not surprisingly, the development of thi...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST20191144
更新日期:2020-06-29 00:00:00
abstract::Peptide-bond formation is the enzymatic activity of the ribosome. The catalytic site is made up of ribosomal RNA, indicating that the ribosome is a ribozyme. This review summarizes the recent progress in understanding the mechanism of peptide bond formation. The results of biochemical and kinetic experiments, mutagene...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
doi:10.1042/BST0330493
更新日期:2005-06-01 00:00:00
abstract::Extracellular electron transfer has, in one decade, emerged from an environmental phenomenon to an industrial process driver. On the one hand, electron transfer towards anodes leads to production of power or chemicals such as hydrogen, caustic soda and hydrogen peroxide. On the other hand, electron transfer from catho...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST20120111
更新日期:2012-12-01 00:00:00
abstract::The Ran GTPase controls many cellular functions, including nucleocytoplasmic trafficking, spindle assembly, nuclear assembly and cell-cycle progression. Considerable evidence suggests that diffusible Ran-GTP near mitotic chromatin facilitates the release of critical factors from nuclear transport receptors, thereby pr...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST0340711
更新日期:2006-11-01 00:00:00
abstract::Site-specific recombinases are enzymes that promote precise rearrangements of DNA sequences. They do this by cutting and rejoining the DNA strands at specific positions within a pair of target sites recognized and bound by the recombinase. One group of these enzymes, the serine recombinases, initiates strand exchange ...
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更新日期:2011-04-01 00:00:00
abstract::Solid-state nuclear magnetic resonance (ssNMR) is an indispensable tool for elucidating the structure and dynamics of insoluble and non-crystalline biomolecules. The recent advances in the sensitivity-enhancing technique magic-angle spinning dynamic nuclear polarization (MAS-DNP) have substantially expanded the territ...
journal_title:Biochemical Society transactions
pub_type: 杂志文章
doi:10.1042/BST20191084
更新日期:2020-06-30 00:00:00
abstract::Signalling by pattern recognition receptors (PRRs) is critical for protecting the host against pathogens. Disruption of these signalling pathways has been implicated in many diseases ranging from infection susceptibility to cancer and autoimmune disease. Understanding how PRRs signal is of critical importance due to t...
journal_title:Biochemical Society transactions
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更新日期:2017-10-15 00:00:00
abstract::Membrane contact sites (MCSs) are subcellular regions where the membranes of distinct organelles come into close apposition. These specialized areas of the cell, which are involved in inter-organelle metabolite exchange, are scaffolded by specific complexes. STARD3 [StAR (steroidogenic acute regulatory protein)-relate...
journal_title:Biochemical Society transactions
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更新日期:2016-04-15 00:00:00
abstract::Effective stroke therapies require recanalization of occluded cerebral blood vessels; however, early reperfusion can cause BBB (blood-brain barrier) injury, leading to cerebral oedema and/or devastating brain haemorrhage. These complications of early reperfusion, which result from excess production of ROS (reactive ox...
journal_title:Biochemical Society transactions
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更新日期:2006-12-01 00:00:00
abstract::AS (alternative splicing) and its role in disease, especially cancer, has come to forefront in research over the last few years. Alterations in the ratio of splice variants have been widely observed in cancer. Splice variants of cancer-associated genes have functions that can alter cellular phenotype, ultimately alter...
journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2012-08-01 00:00:00
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journal_title:Biochemical Society transactions
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abstract::A full picture of the similarities between Family A and Family B GPCRs (G-protein coupled receptors) has been frustrated by the lack of clear homology between the respective sequences. Here, we review previous computational studies on GPCR dimerization in which the putative dimerization interfaces have been analysed u...
journal_title:Biochemical Society transactions
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更新日期:2007-08-01 00:00:00
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journal_title:Biochemical Society transactions
pub_type: 杂志文章,评审
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更新日期:2001-11-01 00:00:00