Inhibition of recombinant GluN1/GluN2A and GluN1/GluN2B N-methyl-D-aspartate receptors by single malt whiskies.

Abstract:

:NMDARs (N-methyl-D-aspartate receptors) are considered to be a target for the inhibitory actions of ethanol. While profound inhibition of both native and recombinant NMDARs can be observed following the application of high concentrations of ethanol the levels of inhibition seen with lower concentrations of ethanol are more modest. Here, we report the effects of inhibiting NMDAR-mediated responses with ethanol concentrations that are experienced during the social consumption of alcohol comparing levels of inhibition seen with 'pure' ethanol with those produced by ethanol contained in three popular single malt whiskies.

journal_name

Biochem Soc Trans

authors

Otton HJ,Janssen A,Wyllie DJ

doi

10.1042/BST0371423

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1423-5

issue

Pt 6

eissn

0300-5127

issn

1470-8752

pii

BST0371423

journal_volume

37

pub_type

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