Like mother, like microbe: human milk oligosaccharide mediated microbiome symbiosis.

abstract：:A novel strategy to treat anxiety and fear-related disorders such as phobias, panic and PTSD (post-traumatic stress disorder) is combining CBT (cognitive behavioural therapy), including extinction-based exposure therapy, with cognitive enhancers. By targeting and boosting mechanisms underlying learning, drug developme...

journal_title：Biochemical Society transactions

authors： Whittle N,Singewald N

更新日期：2014-04-01 00:00:00

abstract：:Uncoupling protein 2 (UCP2) mRNA is expressed in a panoply of tissues, including the brain, where it is widely distributed. In the mouse brain, it is expressed in the hypothalamus (suprachiasmatic, paraventricular, dorsomedial, ventromedial and arcuate nuclei), the thalamus (submedius nucleus) and the brain-stem (dors...

journal_title：Biochemical Society transactions

authors： Richard D,Clavel S,Huang Q,Sanchis D,Ricquier D

更新日期：2001-11-01 00:00:00

abstract：:Many plant viral RNAs lack the 5'-cap structure that is required on all host mRNAs for interacting with essential translation initiation factors. Instead, uncapped viral RNAs take over the host translation machinery by harbouring sequences that functionally replace the 5'-cap. Recent reports reveal at least eight diff...

journal_title：Biochemical Society transactions

authors： Miller WA,Wang Z,Treder K

更新日期：2007-12-01 00:00:00

abstract：:PTB (polypyrimidine tract-binding protein) is an abundant and widely expressed RNA-binding protein with four RRM (RNA recognition motif) domains. PTB is involved in numerous post-transcriptional steps in gene expression in both the nucleus and cytoplasm, but has been best characterized as a regulatory repressor of som...

journal_title：Biochemical Society transactions

authors： Kafasla P,Mickleburgh I,Llorian M,Coelho M,Gooding C,Cherny D,Joshi A,Kotik-Kogan O,Curry S,Eperon IC,Jackson RJ,Smith CW

更新日期：2012-08-01 00:00:00

abstract：:The completely sequenced genome of the cyanobacterium Synechocystis PCC 6803 contains several open reading frames, of which the deduced amino acid sequences show similarities to proteins known to be involved in FeS cluster synthesis of nitrogenase (Nif proteins) and other FeS proteins (Isc proteins). In this article, ...

journal_title：Biochemical Society transactions

authors： Seidler A,Jaschkowitz K,Wollenberg M

更新日期：2001-08-01 00:00:00

abstract：:SUMOylation of viral proteins is widespread and serves to modify or regulate the properties of those proteins. Papillomaviruses are a large group of small DNA viruses that infect the skin, leading to benign lesions (warts) that in some cases can progress to malignancy. The papillomavirus life cycle is intimately conne...

journal_title：Biochemical Society transactions

authors： Wu YC,Deyrieux AF,Wilson VG

更新日期：2007-12-01 00:00:00

abstract：:There has been a revolution in understanding animal development in the last 25 years or so, but there is at least one area of development that has been relatively neglected and therefore remains largely mysterious. This is the intracellular programmes and timers that run in developing precursor cells and change the ce...

journal_title：Biochemical Society transactions

authors： Raff M

更新日期：2006-11-01 00:00:00

abstract：:Photosynthesis is fundamental to biomass production, but is a dynamic process sensitive to environmental constraints. In recent years, approaches to increase biomass and grain yield by altering photosynthetically related processes in the plant have received considerable attention. However, improving biomass yield requ...

journal_title：Biochemical Society transactions

authors： Heyneke E,Fernie AR

更新日期：2018-04-17 00:00:00

abstract：:Glucotoxicity plays a major role in pancreatic beta-cell apoptosis and diabetes progression, but the factors involved have remained largely unknown. Our recent studies have identified TXNIP (thioredoxin-interacting protein) as a novel pro-apoptotic beta-cell factor that is induced by glucose, suggesting that TXNIP may...

journal_title：Biochemical Society transactions

authors： Shalev A

更新日期：2008-10-01 00:00:00

abstract：:The role of Hsp70 (heat-shock protein 70) chaperones in assisting protein-folding processes relies on their ability to associate with short peptide stretches of protein substrates in a transient and ATP-controlled manner. In the present study, we review the molecular details of the mechanism behind substrate recogniti...

journal_title：Biochemical Society transactions

authors： Erbse A,Mayer MP,Bukau B

更新日期：2004-08-01 00:00:00

abstract：:The Wilms' tumour-suppressor gene (WT1), encodes a zinc-finger transcription factor that is critical for the development of several organs, including the kidneys, gonads and spleen. Despite its identification as a tumour suppressor that plays a crucial role in the formation of a paediatric malignancy of the kidneys (W...

journal_title：Biochemical Society transactions

authors： Hartkamp J,Roberts SG

更新日期：2008-08-01 00:00:00

abstract：:Ribonucleic acids are driving a multitude of biological processes where they act alone or in complex with proteins (ribonucleoproteins, RNP). To understand these processes both structural and mechanistic information about RNA is necessary. Due to their conformational plasticity RNA pose a challenge for mainstream stru...

journal_title：Biochemical Society transactions

authors： Sreemantula AK,Marchanka A

更新日期：2020-06-30 00:00:00

abstract：:The expression of diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) with predicted molecular mass of 56.9. kDa (BnDGAT1) was examined using microspore-derived cell suspension cultures of oilseed rape (Brassica napus L. cv Jet Neuf). As well, a recombinant histidine-tagged N-terminal fragment of BnDGAT1 [BnDGAT1((1-11...

journal_title：Biochemical Society transactions

authors： Weselake RJ,Nykiforuk CL,Laroche A,Patterson NA,Wiehler WB,Szarka SJ,Moloney MM,Tari LW,Derekh U

更新日期：2000-12-01 00:00:00

abstract：:One of the major goals of modern plant biotechnology is to manipulate lipid metabolism in oilseed crops to produce new and improved edible and industrial vegetable oils. Lipids constitute the structural components of cellular membranes and act as sources of energy for the germinating seed and are therefore essential t...

journal_title：Biochemical Society transactions

authors： Schnurr JA,Shockey J,Browse J

更新日期：2000-12-01 00:00:00

abstract：:From a protein structural viewpoint, tryptophan is often considered an inert structural amino acid, playing a role as a hydrophobic anchor in membrane proteins or as part of the hydrophobic core of soluble proteins. However, tryptophan is the only polyaromatic amino acid and, from a chemical viewpoint, possesses uniqu...

journal_title：Biochemical Society transactions

authors： Naismith JH

更新日期：2012-06-01 00:00:00

abstract：:Unr (upstream of N-ras) is a eukaryotic RNA-binding protein that has a number of roles in the post-transcriptional regulation of gene expression. Originally identified as an activator of internal initiation of picornavirus translation, it has since been shown to act as an activator and inhibitor of cellular translatio...

journal_title：Biochemical Society transactions

authors： Ray S,Catnaigh PÓ,Anderson EC

更新日期：2015-06-01 00:00:00

abstract：:Non-coding transcripts play an important role in gene expression regulation in all species, including budding and fission yeast. Such regulatory transcripts include intergenic ncRNA (non-coding RNA), 5' and 3' UTRs, introns and antisense transcripts. In the present review, we discuss advantages and limitations of rece...

journal_title：Biochemical Society transactions

authors： Schlackow M,Gullerova M

更新日期：2013-12-01 00:00:00

abstract：:Studies on those enzymes and electron-transfer proteins involved in the catabolism of 'C1' substrates in methylotrophic bacteria have provided a wealth of information concerning the transfer of electrons and hydrogen by quantum tunnelling mechanisms. With regard to H-transfer, studies with MADH have provided the first...

journal_title：Biochemical Society transactions

authors： Scrutton NS

更新日期：1999-12-01 00:00:00

abstract：:Post-translational modification (PTM) of histones has been investigated in eukaryotes for years, revealing its widespread occurrence and functional importance. Many PTMs affect chromatin folding and gene activity. Only recently the occurrence of such modifications has been recognized in bacteria. However, it is unclea...

journal_title：Biochemical Society transactions

authors： Dilweg IW,Dame RT

更新日期：2018-10-19 00:00:00

abstract：:An important aspect of the cytochrome c electrochemistry is the possibility of coupling the 'heterogeneous reactions' with other redox enzymes. Cellobiose dehydrogenase, a 89170 Da glycoprotein that contains both FAD and a b-type haem as prosthetic groups, donates electrons to a number of acceptors, including cytochro...

journal_title：Biochemical Society transactions

authors： Fridman V,Wollenberger U,Bogdanovskaya V,Lisdat F,Ruzgas T,Lindgren A,Gorton L,Scheller FW

更新日期：2000-02-01 00:00:00

abstract：:Allostery is a biological phenomenon of critical importance in metabolic regulation and cell signalling. The fundamental premise of classical models that describe allostery is that structure mediates 'action at a distance'. Recently, this paradigm has been challenged by the enrichment of IDPs (intrinsically disordered...

journal_title：Biochemical Society transactions

authors： Motlagh HN,Li J,Thompson EB,Hilser VJ

更新日期：2012-10-01 00:00:00

abstract：:The calcium-sensing receptor is a multimodal, multimetabolic sensor that mediates the feedback-dependent control of whole body calcium metabolism. Remarkably, in addition to its role in Ca(2+)(o) (extracellular Ca(2+)) sensing, the CaR (Ca(2+)-sensing receptor) also responds to L-amino acids. L-amino acids appear to a...

journal_title：Biochemical Society transactions

authors： Conigrave AD,Mun HC,Brennan SC

更新日期：2007-11-01 00:00:00

abstract：:Voltage-gated K(+) channels are key regulators of neuronal excitability. The Kv2.1 voltage-gated K(+) channel is the major delayed rectifier K(+) channel expressed in most central neurons, where it exists as a highly phosphorylated protein. Kv2.1 plays a critical role in homoeostatic regulation of intrinsic neuronal e...

journal_title：Biochemical Society transactions

authors： Mohapatra DP,Park KS,Trimmer JS

更新日期：2007-11-01 00:00:00

abstract：:The 26S proteasome is a non-lysosomal protease in the cytosol and nucleus of eukaryotic cells. Its main function is to mediate ubiquitin-dependent proteolysis. The 26S proteasome is a multimeric complex composed by the 20S proteasome CP (core particle) and the 19S RPs (regulatory particles). Although the atomic struct...

journal_title：Biochemical Society transactions

authors： Matias AC,Ramos PC,Dohmen RJ

更新日期：2010-02-01 00:00:00

abstract：:Sensing and signalling events that detect abiotic stress-induced changes in plant water status and initiate downstream stress responses such as ABA (abscisic acid) accumulation and osmoregulation remain uncharacterized in plants. Although conclusive results are lacking, recent results from plants, and analogies to sig...

journal_title：Biochemical Society transactions

authors： Verslues PE,Zhu JK

更新日期：2005-04-01 00:00:00

abstract：:Using the Edmonton protocol, a number of patients with Type 1 diabetes mellitus have remained insulin-independent for prolonged periods of time. In spite of this success, transplantation of islets from cadaver donors will remain a therapy for very few patients owing to a lack of donors. Thus, if cell therapy should be...

journal_title：Biochemical Society transactions

authors： Semb H

更新日期：2008-06-01 00:00:00

abstract：:In the present paper, we describe multiple levels of cross-talk between the PI3K (phosphoinositide 3-kinase)/Akt and Ras/MAPK (mitogen-activated protein kinase) signalling pathways. Experimental data and computer simulations demonstrate that cross-talk is context-dependent and that both pathways can activate or inhibi...

journal_title：Biochemical Society transactions

authors： Aksamitiene E,Kiyatkin A,Kholodenko BN

更新日期：2012-02-01 00:00:00

abstract：:AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptor trafficking is a fundamental mechanism for regulating synaptic strength, and hence may underlie cellular processes involved in learning and memory. PICK1 (protein that interacts with protein C-kinase) has recently emerged as a key regulator of AM...

journal_title：Biochemical Society transactions

authors： Hanley JG

更新日期：2006-11-01 00:00:00

abstract：:IL (interleukin)-4 and IL-13 are key cytokines in the pathogenesis of allergic inflammatory disease. IL-4 and IL-13 share many functional properties as a result of their utilization of a common receptor complex comprising IL-13Ralpha1 (IL-13 receptor alpha-chain 1) and IL-4Ralpha. The second IL-13R (IL-13 receptor) ha...

journal_title：Biochemical Society transactions

authors： Andrews AL,Nordgren IK,Kirby I,Holloway JW,Holgate ST,Davies DE,Tavassoli A

更新日期：2009-08-01 00:00:00

abstract：:PI3K (phosphoinositide 3-kinase) is a key regulator of cell growth, metabolism and survival. The frequent activation of the PI3K pathway in cancer has stimulated widespread interest in identifying potent and selective inhibitors of PI3K isoforms. The present paper highlights recent progress in identifying such molecul...

journal_title：Biochemical Society transactions

authors： Knight ZA,Shokat KM

更新日期：2007-04-01 00:00:00