Abstract:
:PI3K (phosphoinositide 3-kinase) is a key regulator of cell growth, metabolism and survival. The frequent activation of the PI3K pathway in cancer has stimulated widespread interest in identifying potent and selective inhibitors of PI3K isoforms. The present paper highlights recent progress in identifying such molecules and the challenges that remain for efforts to pharmacologically target the PI3K family.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Knight ZA,Shokat KMdoi
10.1042/BST0350245subject
Has Abstractpub_date
2007-04-01 00:00:00pages
245-9issue
Pt 2eissn
0300-5127issn
1470-8752pii
BST0350245journal_volume
35pub_type
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