Chemically targeting the PI3K family.

Abstract:

:PI3K (phosphoinositide 3-kinase) is a key regulator of cell growth, metabolism and survival. The frequent activation of the PI3K pathway in cancer has stimulated widespread interest in identifying potent and selective inhibitors of PI3K isoforms. The present paper highlights recent progress in identifying such molecules and the challenges that remain for efforts to pharmacologically target the PI3K family.

journal_name

Biochem Soc Trans

authors

Knight ZA,Shokat KM

doi

10.1042/BST0350245

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

245-9

issue

Pt 2

eissn

0300-5127

issn

1470-8752

pii

BST0350245

journal_volume

35

pub_type

杂志文章
  • Colworth Medal Lecture. Enzymes in the quantum world.

    abstract::Studies on those enzymes and electron-transfer proteins involved in the catabolism of 'C1' substrates in methylotrophic bacteria have provided a wealth of information concerning the transfer of electrons and hydrogen by quantum tunnelling mechanisms. With regard to H-transfer, studies with MADH have provided the first...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0270767

    authors: Scrutton NS

    更新日期:1999-12-01 00:00:00

  • AMPK: a cellular energy sensor primarily regulated by AMP.

    abstract::AMPK (AMP-activated protein kinase) is a cellular energy sensor that monitors the ratio of AMP/ATP, and possibly also ADP/ATP, inside cells. Once activated by falling cellular energy levels, it acts to restore energy homoeostasis by switching on catabolic pathways that generate ATP, while switching off anabolic pathwa...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20130244

    authors: Gowans GJ,Hardie DG

    更新日期:2014-02-01 00:00:00

  • A model for the aberrant DNA methylomes in aging cells and cancer cells.

    abstract::DNA methylation at the fifth position of cytosine is a major epigenetic mark conserved in plants and mammals. Genome-wide DNA methylation patterns are dynamically controlled by integrated activities of establishment, maintenance, and removal. In both plants and mammals, a pattern of global DNA hypomethylation coupled ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20180218

    authors: Zhang H,Zhang K,Zhu JK

    更新日期:2019-08-30 00:00:00

  • 3' Uridylation and the regulation of RNA function in the cytoplasm.

    abstract::Degradation of cytoplasmic mRNAs is an important aspect of the regulation of gene function in eukaryotes. Much of what is currently known about the underlying pathways of mRNA decay is derived from studies of the budding yeast Saccharomyces cerevisiae, in which mRNA turnover is initiated by deadenylation, followed eit...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0381150

    authors: Norbury CJ

    更新日期:2010-08-01 00:00:00

  • The latex-fruit syndrome.

    abstract::Approximately 30-50% of individuals who are allergic to natural rubber latex (NRL) show an associated hypersensitivity to some plant-derived foods, especially freshly consumed fruits. This association of latex allergy and allergy to plant-derived foods is called latex-fruit syndrome. An increasing number of plant sour...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0300935

    authors: Wagner S,Breiteneder H

    更新日期:2002-11-01 00:00:00

  • BMP9 is a potential therapeutic agent for use in oral and maxillofacial bone tissue engineering.

    abstract::Oral and maxillofacial surgery is often challenging due to defective bone healing owing to the microbial environment of the oral cavity, the additional involvement of teeth and esthetic concerns. Insufficient bone volume as a consequence of aging and some oral and maxillofacial surgical procedures, such as tumor resec...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20200376

    authors: Liu L,Chen Y,Song D,Huang D

    更新日期:2020-06-30 00:00:00

  • ESCRT proteins, endosome organization and mitogenic receptor down-regulation.

    abstract::Mitogenic tyrosine kinase receptors such as the EGFR (epidermal growth factor receptor) are endocytosed once they are activated at the cell surface. After reaching the early endosome, they are ubiquitinated within their cytosolic domain and are consequently sorted away from recycling receptors. They are then incorpora...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0370146

    authors: Woodman P

    更新日期:2009-02-01 00:00:00

  • Emerging role of Alzheimer's disease-associated ubiquilin-1 in protein aggregation.

    abstract::Abnormal protein aggregation and intracellular or extracellular accumulation of misfolded and aggregated proteins are key events in the pathogenesis of different neurodegenerative diseases. Furthermore, endoplasmic reticulum stress and impairment of the ubiquitin-proteasome system probably contribute to neurodegenerat...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0380150

    authors: Haapasalo A,Viswanathan J,Bertram L,Soininen H,Tanzi RE,Hiltunen M

    更新日期:2010-02-01 00:00:00

  • 'Rumours of my death may have been greatly exaggerated': a brief review of cell death in human intervertebral disc disease and implications for cell transplantation therapy.

    abstract::The avascular nature of the human intervertebral disc is thought to reduce the ability of resident disc cells to maintain their extracellular matrix, rendering the tissue susceptible to degeneration. It has also been suggested that the lack of a blood supply may result in disc cell death via nutrient deprivation. Ther...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0350680

    authors: Johnson WE,Roberts S

    更新日期:2007-08-01 00:00:00

  • The role of microvesicles in cancer progression and drug resistance.

    abstract::Microvesicles are shed constitutively, or upon activation, from both normal and malignant cells. The process is dependent on an increase in cytosolic Ca2+, which activates different enzymes, resulting in depolymerization of the actin cytoskeleton and release of the vesicles. Drug resistance can be defined as the abili...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20120273

    authors: Jorfi S,Inal JM

    更新日期:2013-02-01 00:00:00

  • Tetraspanin CD9 in cell migration.

    abstract::Tetraspanin CD9 is associated with integrin adhesion receptors and it was reported that CD9 regulates integrin-dependent cell migration and invasion. Pro- and anti-migratory effects of CD9 have been linked to adhesion-dependent signalling pathways, including phosphorylation of FAK (focal adhesion kinase) and activatio...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0390563

    authors: Powner D,Kopp PM,Monkley SJ,Critchley DR,Berditchevski F

    更新日期:2011-04-01 00:00:00

  • Therapeutics in Alzheimer's and prion diseases.

    abstract::There is increasing recognition that numerous neurodegenerative conditions have the same underlying pathogenetic mechanism, namely a change in protein conformation, where the beta-sheet content is increased. In Alzheimer's disease, amyloid deposition in the form of neuritic plaques and congophilic angiopathy is driven...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0300574

    authors: Wisniewski T,Brown DR,Sigurdsson EM

    更新日期:2002-08-01 00:00:00

  • Residual dipolar couplings as a tool to study molecular recognition of ubiquitin.

    abstract::RDCs (residual dipolar couplings) in NMR spectroscopy provide information about protein dynamics complementary to NMR relaxation methods, especially in the previously inaccessible time window between the protein correlation time tau(c) and 50 micros. For ubiquitin, new modes of motion of the protein backbone could be ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0361433

    authors: Lakomek NA,Lange OF,Walter KF,Farès C,Egger D,Lunkenheimer P,Meiler J,Grubmüller H,Becker S,de Groot BL,Griesinger C

    更新日期:2008-12-01 00:00:00

  • Mechanistic and functional diversity in the mechanosensory kinases of the titin-like family.

    abstract::The giant cytoskeletal kinases of the titin-like family are emerging as key mediators of stretch-sensing in muscle. It is thought that their elastic conformational deformation during muscle function regulates both their catalysis and the recruitment of regulatory proteins to signalosomes that assemble in their vicinit...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20130085

    authors: Mayans O,Benian GM,Simkovic F,Rigden DJ

    更新日期:2013-08-01 00:00:00

  • Lack of TXNIP protects beta-cells against glucotoxicity.

    abstract::Glucotoxicity plays a major role in pancreatic beta-cell apoptosis and diabetes progression, but the factors involved have remained largely unknown. Our recent studies have identified TXNIP (thioredoxin-interacting protein) as a novel pro-apoptotic beta-cell factor that is induced by glucose, suggesting that TXNIP may...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0360963

    authors: Shalev A

    更新日期:2008-10-01 00:00:00

  • The petite purple photosynthetic powerpack.

    abstract::Photoreaction centres are Nature's solar batteries. These nanometre-scale power producers are responsible for transducing the energy of sunlight into a form that can be used by biological systems, thereby powering most of the biological activity on the planet. Although to the layman the word 'photosynthesis' is usuall...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0370400

    authors: Jones MR

    更新日期:2009-04-01 00:00:00

  • Simple topology: FtsK-directed recombination at the dif site.

    abstract::FtsK is a multifunctional protein, which, in Escherichia coli, co-ordinates the essential functions of cell division, DNA unlinking and chromosome segregation. Its C-terminus is a DNA translocase, the fastest yet characterized, which acts as a septum-localized DNA pump. FtsK's C-terminus also interacts with the XerCD ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20120299

    authors: Grainge I

    更新日期:2013-04-01 00:00:00

  • Recycling domains in plant cell morphogenesis: small GTPase effectors, plasma membrane signalling and the exocyst.

    abstract::The Rho/Rop small GTPase regulatory module is central for initiating exocytotically ACDs (active cortical domains) in plant cell cortex, and a growing array of Rop regulators and effectors are being discovered in plants. Structural membrane phospholipids are important constituents of cells as well as signals, and phos...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0380723

    authors: Zárský V,Potocký M

    更新日期:2010-04-01 00:00:00

  • CYP74C3 and CYP74A1, plant cytochrome P450 enzymes whose activity is regulated by detergent micelle association, and proposed new rules for the classification of CYP74 enzymes.

    abstract::CYP74C3 (cytochrome P450 subfamily 74C3), an HPL (hydroperoxide lyase) from Medicago truncatula (barrel medic), and CYP74A1, an AOS (allene oxide synthase) from Arabidopsis thaliana, are key membrane-associated P450 enzymes in plant oxylipin metabolism. Both recombinant detergent-free enzymes are monomeric proteins wi...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST0341223

    authors: Hughes RK,Belfield EJ,Casey R

    更新日期:2006-12-01 00:00:00

  • Evolutionary selection for protein aggregation.

    abstract::Protein aggregation is being found to be associated with an increasing number of human diseases. Aggregation can lead to a loss of function (lack of active protein) or to a toxic gain of function (cytotoxicity associated with protein aggregates). Although potentially harmful, protein sequences predisposed to aggregati...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20120160

    authors: Sanchez de Groot N,Torrent M,Villar-Piqué A,Lang B,Ventura S,Gsponer J,Babu MM

    更新日期:2012-10-01 00:00:00

  • Structural basis of natural ligand binding and activation of the Class II G-protein-coupled secretin receptor.

    abstract::The secretin receptor is prototypic of Class II GPCRs (G-protein-coupled receptors), based on its structural and functional characteristics and those of its natural agonist ligand. Secretin represents a linear 27-residue peptide with diffuse pharmacophoric domain. The secretin receptor includes the typical signature s...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0350709

    authors: Miller LJ,Dong M,Harikumar KG,Gao F

    更新日期:2007-08-01 00:00:00

  • Role of p90(RSK) in regulating the Crabtree effect: implications for cancer.

    abstract::High glucose inhibits mitochondrial respiration, known as the 'Crabtree effect', in cancer cells and possibly other cell types. The upstream pathways regulating this phenomenon are poorly understood. In diabetes, where glucose levels are elevated, the p90(RSK) (p90 ribosomal S6 kinase) has received much attention as a...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章

    doi:10.1042/BST20120277

    authors: Redman EK,Brookes PS,Karcz MK

    更新日期:2013-02-01 00:00:00

  • Rho-ROCK signaling regulates tumor-microenvironment interactions.

    abstract::Reciprocal biochemical and biophysical interactions between tumor cells, stromal cells and the extracellular matrix (ECM) result in a unique tumor microenvironment that determines disease outcome. The cellular component of the tumor microenvironment contributes to tumor growth by providing nutrients, assisting in the ...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20180334

    authors: Johan MZ,Samuel MS

    更新日期:2019-02-28 00:00:00

  • Roles of PPARdelta in the control of muscle development and metabolism.

    abstract::PPARdelta (peroxisome proliferator-activated receptor delta)-specific agonists decrease plasma lipids and insulinaemia in obese animals. As skeletal muscle is one of the major organs for fatty acid catabolism, we have investigated the roles of the nuclear receptor in the control of muscle development and lipid metabol...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0311130

    authors: Grimaldi PA

    更新日期:2003-12-01 00:00:00

  • Do mitochondrial DNA mutations have a role in neurodegenerative disease?

    abstract::A decline in mitochondrial function has long been shown to exist in neurodegenerative disease. Whether this decline is a secondary consequence of other factors or whether it causes the eventual death of a cell is unknown. In this review, we will discuss some of the major evidence surrounding mitochondrial DNA mutation...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0351232

    authors: Krishnan KJ,Reeve AK,Turnbull DM

    更新日期:2007-11-01 00:00:00

  • Dissecting DISC1 function through protein-protein interactions.

    abstract::Disrupted in schizophrenia 1 (DISC1) is emerging in the eyes of many as the most promising candidate of all the schizophrenia risk genes. This viewpoint is derived from the combination of genetic, clinical, imaging and rapidly advancing cell biology data around this gene. All of these areas have been reviewed extensiv...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST0351283

    authors: Brandon NJ

    更新日期:2007-11-01 00:00:00

  • Polyamine dependence of normal cell-cycle progression.

    abstract::The driving force of the cell cycle is the activities of cyclin-dependent kinases (CDKs). Key steps in the regulation of the cell cycle therefore must impinge upon the activities of the CDKs. CDKs exert their functions when bound to cyclins that are expressed cyclically during the cell cycle. Polyamine biosynthesis va...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0310366

    authors: Oredsson SM

    更新日期:2003-04-01 00:00:00

  • Btk-dependent regulation of phosphoinositide synthesis.

    abstract::Activation of the BCR (B cell antigen receptor) stimulates the production of both PtdIns(3,4,5) P3 and Ins(1,4,5) P3. PtdIns(3,4,5) P3 and Ins(1,4,5) P3 are generated from a common substrate, PtdIns(4,5) P2. In some systems, continuous PtdIns(4,5) P2 synthesis is necessary for maximal Ins(1,4,5) P3 production, but whe...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0320326

    authors: Carpenter CL

    更新日期:2004-04-01 00:00:00

  • Enzymes of yeast polyphosphate metabolism: structure, enzymology and biological roles.

    abstract::Inorganic polyphosphate (polyP) is found in all living organisms. The known polyP functions in eukaryotes range from osmoregulation and virulence in parasitic protozoa to modulating blood coagulation, inflammation, bone mineralization and cellular signalling in mammals. However mechanisms of regulation and even the id...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/BST20150213

    authors: Gerasimaitė R,Mayer A

    更新日期:2016-02-01 00:00:00

  • New functions of the MHC class I-related Fc receptor, FcRn.

    abstract::FcRn was originally identified as the receptor responsible for IgG binding to the intestinal epithelium of neonatal rats and mice. FcRn transports IgG from milk across the intestinal epithelial cells of the suckling animal. Subsequently, FcRn was detected in tissues involved in the transmission of IgG from mother to f...

    journal_title:Biochemical Society transactions

    pub_type: 杂志文章,评审

    doi:10.1042/bst0250481

    authors: Simister NE,Jacobowitz Israel E,Ahouse JC,Story CM

    更新日期:1997-05-01 00:00:00