Abstract:
:The Wilms' tumour-suppressor gene (WT1), encodes a zinc-finger transcription factor that is critical for the development of several organs, including the kidneys, gonads and spleen. Despite its identification as a tumour suppressor that plays a crucial role in the formation of a paediatric malignancy of the kidneys (Wilms' tumour), it has also emerged as an oncogenic factor influencing proliferation and apoptosis in a large variety of adult cancers. This review focuses on new insights into WT1's role in early development and its potential oncogenic role in adult cancer.
journal_name
Biochem Soc Transjournal_title
Biochemical Society transactionsauthors
Hartkamp J,Roberts SGdoi
10.1042/BST0360629subject
Has Abstractpub_date
2008-08-01 00:00:00pages
629-31issue
Pt 4eissn
0300-5127issn
1470-8752pii
BST0360629journal_volume
36pub_type
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