Role of the Rab11 pathway in negative-strand virus assembly.

abstract：:Metabolic and epidemiologic studies support the idea that the type of dietary fat is more important than the total amount of fat with respect to the development of atherosclerosis and the risk of cardiovascular heart disease. Dietary fat is carried in CMs (chylomicrons), which can be taken up by macrophages without ne...

journal_title：Biochemical Society transactions

authors： Cabello-Moruno R,Perona JS,Ruiz-Gutierrez V

更新日期：2007-06-01 00:00:00

abstract：:The inositol-depletion hypothesis was suggested to explain the therapeutic mechanism of mood-stabilizing drugs. Focus was previously on the phosphatidylinositol signalling pathway and on the regulatory roles of Ins(3,4,5)P(3) and DAG (diacylglycerol). Recent findings indicate that inositol and inositol-containing mole...

journal_title：Biochemical Society transactions

authors： Deranieh RM,Greenberg ML

更新日期：2009-10-01 00:00:00

abstract：:XRCC4 (X-ray cross-complementation group 4) and XLF (XRCC4-like factor) are two essential interacting proteins in the human NHEJ (non-homologous end-joining) pathway that repairs DNA DSBs (double-strand breaks). The individual crystal structures show that the dimeric proteins are homologues with protomers containing h...

journal_title：Biochemical Society transactions

authors： Wu Q,Ochi T,Matak-Vinkovic D,Robinson CV,Chirgadze DY,Blundell TL

更新日期：2011-10-01 00:00:00

abstract：:P-type ATPases transport ions across biological membranes against concentration gradients and are essential for all cells. They use the energy from ATP hydrolysis to propel large intramolecular movements, which drive vectorial transport of ions. Tight coordination of the motions of the pump is required to couple the t...

journal_title：Biochemical Society transactions

authors： Dyla M,Basse Hansen S,Nissen P,Kjaergaard M

更新日期：2019-10-31 00:00:00

abstract：:Membrane contact sites (MCSs) are subcellular regions where the membranes of distinct organelles come into close apposition. These specialized areas of the cell, which are involved in inter-organelle metabolite exchange, are scaffolded by specific complexes. STARD3 [StAR (steroidogenic acute regulatory protein)-relate...

journal_title：Biochemical Society transactions

authors： Wilhelm LP,Tomasetto C,Alpy F

更新日期：2016-04-15 00:00:00

abstract：:Malaria during pregnancy is caused when parasite-infected erythrocytes accumulate within the placenta through interactions between the VAR2CSA protein on the infected erythrocyte surface and placental CSPGs (chondroitin sulfate proteoglycans). This interaction is the major target for therapeutics to treat or prevent p...

journal_title：Biochemical Society transactions

authors： Khunrae P,Higgins MK

更新日期：2010-10-01 00:00:00

abstract：:After the discovery of leucine-rich repeat kinase 2 (LRRK2) as a risk factor for sporadic Parkinson's disease (PD) and mutations in LRRK2 as a cause of some forms of familial PD, there has been substantial interest in finding chemical modulators of LRRK2 function. Most of the pathogenic mutations in LRRK2 are within t...

journal_title：Biochemical Society transactions

authors： Mortiboys H

更新日期：2016-12-15 00:00:00

abstract：:Gene-poor human chromosomes are reproducibly found at the nuclear periphery in proliferating cells. There are a number of inner nuclear envelope proteins that may have roles in chromosome location and anchorage, e.g. emerin and A-type lamins. In the last decade, a number of diseases associated with tissue degeneration...

journal_title：Biochemical Society transactions

authors： Meaburn KJ,Levy N,Toniolo D,Bridger JM

更新日期：2005-12-01 00:00:00

abstract：:PGs (prostaglandins) are synthesized through the cyclo-oxygenase (COX-1 and -2) pathway in a variety of cells in response to various physiological stimuli. All cells require at least one pathway for apoptosis, and mitochondrial play a central role in regulation of apoptosis. In a previous study, incubation of A549 cel...

journal_title：Biochemical Society transactions

authors： Fang KM,Shu WH,Chang HC,Wang JJ,Mak OT

更新日期：2004-12-01 00:00:00

abstract：:Resveratrol (3,4',5-trihydroxystilbene) is found in various plants, including grapes, berries and peanuts. It is also present in wines, especially red wines. During the last years, it has been the focus of numerous in vitro and in vivo studies investigating its biological attributes, which include mainly antioxidant a...

journal_title：Biochemical Society transactions

authors： de la Lastra CA,Villegas I

更新日期：2007-11-01 00:00:00

abstract：:Sugars that are readily respired by plant cells inhibit greening when dO2 and mu are relatively high. As sugar concentration in the batch culture medium is depleted and mu declines, greening is permitted. The mechanism of this effect has not been satisfactorily explained. ...

journal_title：Biochemical Society transactions

authors： Dalton C

更新日期：1980-08-01 00:00:00

abstract：:GRIF-1 [GABA(A) (gamma-aminobutyric acid(A)) receptor interacting factor-1] is a member of a coiled-coil family of proteins thought to function as adaptors in the anterograde trafficking of organelles utilizing the kinesin-1 motor proteins to synapses. To study in more detail the molecular interaction between GRIF-1 a...

journal_title：Biochemical Society transactions

authors： Pozo K,Stephenson FA

更新日期：2006-02-01 00:00:00

abstract：:The role of Hsp70 (heat-shock protein 70) chaperones in assisting protein-folding processes relies on their ability to associate with short peptide stretches of protein substrates in a transient and ATP-controlled manner. In the present study, we review the molecular details of the mechanism behind substrate recogniti...

journal_title：Biochemical Society transactions

authors： Erbse A,Mayer MP,Bukau B

更新日期：2004-08-01 00:00:00

abstract：:TDP-43 (TAR DNA-binding protein 43) is an hnRNP (heterogeneous nuclear ribonucleoprotein) protein whose role in cellular processes has come to the forefront of neurodegeneration research after the observation that it is the main component of brain inclusions in ALS (amyotrophic lateral sclerosis) and FTLD (frontotempo...

journal_title：Biochemical Society transactions

authors： Baralle M,Buratti E,Baralle FE

更新日期：2013-12-01 00:00:00

abstract：:Neutrophils are very abundant, short-lived leucocytes and their death by apoptosis is central to homoeostasis and the resolution of inflammation, yet the trigger for apoptosis is still a topic of debate. Depolarization of the mitochondrial membrane has been supposed to initiate neutrophil spontaneous apoptosis, as neu...

journal_title：Biochemical Society transactions

authors： Scheel-Toellner D,Wang KQ,Webb PR,Wong SH,Craddock R,Assi LK,Salmon M,Lord JM

更新日期：2004-06-01 00:00:00

abstract：:The production of dihydrogen by Escherichia coli and other members of the Enterobacteriaceae is one of the classic features of mixed-acid fermentation. Synthesis of the multicomponent, membrane-associated FHL (formate hydrogenlyase) enzyme complex, which disproportionates formate into CO(2) and H(2), has an absolute r...

journal_title：Biochemical Society transactions

authors： Sawers RG

更新日期：2005-02-01 00:00:00

abstract：:Other than signalling receptors sustaining leucocyte recruitment during inflammatory reactions, the chemokine system includes 'silent' receptors with distinct specificity and tissue distribution. The best-characterized molecule of this subgroup is the CC chemokine receptor D6, which binds most inflammatory CC chemokin...

journal_title：Biochemical Society transactions

authors： Borroni EM,Buracchi C,de la Torre YM,Galliera E,Vecchi A,Bonecchi R,Mantovani A,Locati M

更新日期：2006-12-01 00:00:00

abstract：:One of the major goals of modern plant biotechnology is to manipulate lipid metabolism in oilseed crops to produce new and improved edible and industrial vegetable oils. Lipids constitute the structural components of cellular membranes and act as sources of energy for the germinating seed and are therefore essential t...

journal_title：Biochemical Society transactions

authors： Schnurr JA,Shockey J,Browse J

更新日期：2000-12-01 00:00:00

abstract：:Phosphorus is one of the most important macronutrients and is indispensable for all organisms as a critical structural component as well as participating in intracellular signalling and energy metabolism. Sensing and signalling of phosphate (Pi) has been extensively studied and is well understood in single-cellular or...

journal_title：Biochemical Society transactions

authors： Qi W,Baldwin SA,Muench SP,Baker A

更新日期：2016-06-15 00:00:00

abstract：:Genomic DNA is constantly under threat from intracellular and environmental factors that damage its chemical structure. Uncorrected DNA damage may impede cellular propagation or even result in cell death, making it critical to restore genomic integrity. Decades of research have revealed a wide range of mechanisms thro...

journal_title：Biochemical Society transactions

authors： Ghodke H,Ho H,van Oijen AM

更新日期：2018-02-19 00:00:00

abstract：:The examples shown here illustrate the power of gene targeting to the epidermis as a means of developing animal models for the study of human skin diseases. In this short review, I have focused on contributions which stem predominantly from my own laboratory [31, 32, 34, 37, 47]. However, other laboratories have also ...

journal_title：Biochemical Society transactions

authors： Fuchs E

更新日期：1991-11-01 00:00:00

abstract：:Whereas spontaneous point mutation operates on nucleotides individually, sexual recombination manipulates the set of nucleotides within an allele as an essentially particulate unit. In principle, these two different scales of variation enable selection to follow fitness gradients in two different spaces: in nucleotide...

journal_title：Biochemical Society transactions

authors： Watson RA,Weinreich DM,Wakeley J

更新日期：2006-08-01 00:00:00

abstract：:RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases that are critical for the degradation of cytoplasmic RNAs. Although the molecular mechanisms of RNA degradation by DIS3L2 and XRN1 h...

journal_title：Biochemical Society transactions

authors： Pashler AL,Towler BP,Jones CI,Newbury SF

更新日期：2016-10-15 00:00:00

abstract：:The advantages of Hansenula polymorpha as a new yeast expression system are discussed in terms of the powerful and regulatable methanol oxidase promoter and the organism's ability to grow on cheap carbon sources. The development of techniques for conventional genetic analysis is described. A total of 218 mutants have ...

journal_title：Biochemical Society transactions

authors： Sudbery PE,Gleeson MA,Veale RA,Ledeboer AM,Zoetmulder MC

更新日期：1988-12-01 00:00:00

abstract：:Genes encoding an alpha-oxygenase, in Nicotiana tabacum and Arabidopsis thaliana, have been recently isolated. However, the reaction mechanism of the enzyme has not so far been elucidated. In this study, a cDNA encoding the fatty acid alpha-oxygenase gene in rice plants was isolated. The deduced amino acid sequence sh...

journal_title：Biochemical Society transactions

authors： Koeduka T,Matsui K,Akakabe Y,Kajiwara T

更新日期：2000-12-01 00:00:00

abstract：:The glutamate/aspartate transporter GLAST-1 is expressed in bone in vivo and also exists as a splice variant (GLAST-1a) in which exon 3 is excluded. Since GLAST-1 expression is regulated in bone in response to osteogenic mechanical stimuli in vivo and binding of glutamate to receptors on osteoblasts increases osteobla...

journal_title：Biochemical Society transactions

authors： Huggett JF,Mustafa A,O'neal L,Mason DJ

更新日期：2002-11-01 00:00:00

abstract：:Signalling by pattern recognition receptors (PRRs) is critical for protecting the host against pathogens. Disruption of these signalling pathways has been implicated in many diseases ranging from infection susceptibility to cancer and autoimmune disease. Understanding how PRRs signal is of critical importance due to t...

journal_title：Biochemical Society transactions

authors： Macleod C,Bryant CE

更新日期：2017-10-15 00:00:00

abstract：:Numerous bacterial proteins involved in the nitrogen cycle, and other processes, require c-type haem as a cofactor. c-type cytochromes are formed by covalent attachment of haem to the conserved CXXCH motif. Here, we briefly review what is presently known about cytochrome c maturation in Bacillus subtilis with particul...

journal_title：Biochemical Society transactions

authors： Crow A,Le Brun NE,Oubrie A

更新日期：2005-02-01 00:00:00

abstract：:There is increasing recognition that numerous neurodegenerative conditions have the same underlying pathogenetic mechanism, namely a change in protein conformation, where the beta-sheet content is increased. In Alzheimer's disease, amyloid deposition in the form of neuritic plaques and congophilic angiopathy is driven...

journal_title：Biochemical Society transactions

authors： Wisniewski T,Brown DR,Sigurdsson EM

更新日期：2002-08-01 00:00:00

abstract：:Biotin, which serves as a carboxyl group carrier in reactions catalyzed by biotin-dependent carboxylases, is essential for life in most organisms. To function in carboxylate transfer, the vitamin must be post-translationally linked to a specific lysine residue on the biotin carboxyl carrier (BCC) of a carboxylase in a...

journal_title：Biochemical Society transactions

authors： Beckett D

更新日期：2018-12-17 00:00:00