Formate and its role in hydrogen production in Escherichia coli.

abstract：:Polycomb group (PcG) proteins are highly conserved chromatin-modifying complexes that implement gene silencing in higher eukaryotes. Thousands of genes and multiple developmental processes are regulated by PcG proteins. As the first chromatin modifier been identified in model plant Arabidopsis thaliana, the methyltran...

journal_title：Biochemical Society transactions

authors： Jiao H,Xie Y,Li Z

更新日期：2020-08-28 00:00:00

abstract：:Many Zn(II)2Cys6 transcriptional regulators exhibit changes in phosphorylation that are coincident with their roles in transcriptional activation. It is, however, unclear whether these changes occur as a cause of, or as a result of, transcriptional activation. In this paper, we explore the relationship between these t...

journal_title：Biochemical Society transactions

authors： Leverentz MK,Reece RJ

更新日期：2006-11-01 00:00:00

abstract：:The Drosophila melanogaster flightless I protein and its homologues in higher eukaryotes (FliI) are conserved members of the gelsolin family of actin-binding proteins. Members of the gelsolin family generally contain three or six copies of a 125-amino-acid residue gelsolin-related repeating unit, and may contain addit...

journal_title：Biochemical Society transactions

authors： Archer SK,Behm CA,Claudianos C,Campbell HD

更新日期：2004-12-01 00:00:00

abstract：:Native disulphide bonds are essential for the structure and function of many membrane and secretory proteins. Disulphide bonds are formed, reduced and isomerized in the endoplasmic reticulum of mammalian cells by a family of oxidoreductases, which includes protein disulphide isomerase (PDI), ERp57, ERp72, P5 and PDIR....

journal_title：Biochemical Society transactions

authors： Jessop CE,Chakravarthi S,Watkins RH,Bulleid NJ

更新日期：2004-11-01 00:00:00

abstract：:Biological diversity in marine OMZs (oxygen minimum zones) is dominated by a complex community of bacteria and archaea whose anaerobic metabolisms mediate key steps in global nitrogen and carbon cycles. Molecular and physiological studies now confirm that OMZs also support diverse micro-organisms capable of utilizing ...

journal_title：Biochemical Society transactions

authors： Stewart FJ

更新日期：2011-12-01 00:00:00

abstract：:Identified five decades ago amongst the most abundant cellular RNAs, small nucleolar RNAs (snoRNAs) were initially described as serving as guides for the methylation and pseudouridylation of ribosomal RNA through direct base pairing. In recent years, however, increasingly powerful high-throughput genomic approaches an...

journal_title：Biochemical Society transactions

authors： Bergeron D,Fafard-Couture É,Scott MS

更新日期：2020-04-29 00:00:00

abstract：:The Cat family of genes have revealed unexpected complexity and regulation. The first 5 years of research have been productive, yet many important questions remain to be addressed. A major problem for the field of amino acid transport is a severe paucity of data on the structure of these proteins and their arrangement...

journal_title：Biochemical Society transactions

authors： MacLeod CL

更新日期：1996-08-01 00:00:00

abstract：:DNA topology changes dynamically during DNA replication. Supercoiling, precatenation, catenation and knotting interplay throughout the process that is finely regulated by DNA topoisomerases. In the present article, we provide an overview of theoretical and experimental approaches to understand the interplay between va...

journal_title：Biochemical Society transactions

authors： Schvartzman JB,Martínez-Robles ML,Hernández P,Krimer DB

更新日期：2013-04-01 00:00:00

abstract：:Tyrosine kinases are signaling molecules that are common to all metazoans and are involved in the regulation of many cellular processes such as proliferation and survival. While most attention has been devoted to tyrosine kinases signaling at the plasma membrane and the cytosol, very little attention has been dedicate...

journal_title：Biochemical Society transactions

authors： Farhan H

更新日期：2020-02-28 00:00:00

abstract：:The formation of complexes between growth factor receptors and members of a family of G-protein-coupled receptors whose natural ligands are S1P (sphingosine 1-phosphate) and LPA (lysophosphatidic acid) represents a new signalling entity. This receptor complex allows for integrated signalling in response to growth fact...

journal_title：Biochemical Society transactions

authors： Pyne NJ,Waters C,Moughal NA,Sambi BS,Pyne S

更新日期：2003-12-01 00:00:00

abstract：:Glucose 6-phosphate is an intermediate of pathways of glucose utilization and production as well as a regulator of enzyme activity and gene expression. Studies on the latter functions are in part based on measurement of the glucose 6-phosphate content in a whole-cell extract. Several studies have suggested that there ...

journal_title：Biochemical Society transactions

authors： Agius L,Centelles J,Cascante M

更新日期：2002-04-01 00:00:00

abstract：:Congenital malformations are major causes of disease and death during the first years of life and, most of the time, functional replacement of the missing or damaged organs remains an unmet clinical need. Particularly relevant for the treatment of congenital malformation would be to collect the stem cells at diagnosis...

journal_title：Biochemical Society transactions

authors： De Coppi P

更新日期：2014-06-01 00:00:00

abstract：:Luteinizing hormone (LH) interacts with its plasma membrane receptor to activate the formation of cyclic AMP via the regulatory GTP binding protein (Gs). This is followed by a desensitization of that same hormonal response which is caused by an uncoupling of the LH receptor from Gs. The coupling between Gs and the ade...

journal_title：Biochemical Society transactions

authors： Cooke BA,Platts EA,Abayasekera DR,Rose MP

更新日期：1989-08-01 00:00:00

abstract：:Here, we describe a recently discovered O-GlcNAc transferase termed EOGT for EGF domain-specific O-GlcNAc transferase. EOGT transfers GlcNAc (N-acetylglucosamine) to Ser or Thr in secreted and membrane proteins that contain one or more epidermal growth factor-like repeats with a specific consensus sequence. Thus, EOGT...

journal_title：Biochemical Society transactions

authors： Varshney S,Stanley P

更新日期：2017-04-15 00:00:00

abstract：:IL (interleukin)-4 and IL-13 are key cytokines in the pathogenesis of allergic inflammatory disease. IL-4 and IL-13 share many functional properties as a result of their utilization of a common receptor complex comprising IL-13Ralpha1 (IL-13 receptor alpha-chain 1) and IL-4Ralpha. The second IL-13R (IL-13 receptor) ha...

journal_title：Biochemical Society transactions

authors： Andrews AL,Nordgren IK,Kirby I,Holloway JW,Holgate ST,Davies DE,Tavassoli A

更新日期：2009-08-01 00:00:00

abstract：:As beta-secretase, memapsin 2 cleaves amyloid-beta precursor protein, which leads ultimately to the onset of Alzheimer's disease. As such, memapsin 2 is an excellent target of inhibitor drugs for the treatment of this disease. Here we describe the tools for memapsin 2 inhibitor design that have been developed and resu...

journal_title：Biochemical Society transactions

authors： Hong L,Turner RT 3rd,Koelsch G,Ghosh AK,Tang J

更新日期：2002-08-01 00:00:00

abstract：:Microscopes are used to characterize small objects with the help of probes that interact with the specimen, such as photons and electrons in optical and electron microscopies, respectively. In atomic force microscopy (AFM), the probe is a nanometric tip located at the end of a microcantilever which palpates the specim...

journal_title：Biochemical Society transactions

authors： Moreno-Madrid F,Martín-González N,Llauró A,Ortega-Esteban A,Hernando-Pérez M,Douglas T,Schaap IA,de Pablo PJ

更新日期：2017-04-15 00:00:00

abstract：:The collagens of vertebrates may be divided into three groups according to chain size and whether or not the helical domains are continuous. Present evidence suggests that, at least within one of these groups, similarity between collagens is reflected in the organization of the genes that encode them. Early evidence s...

journal_title：Biochemical Society transactions

authors： Dalgleish R

更新日期：1988-10-01 00:00:00

abstract：:In plants, the spatial arrangement of cells within tissues and organs is a direct consequence of the positioning of the new cell walls during cell division. Since the nineteenth century, scientists have proposed rules to explain the orientation of plant cell divisions. Most of these rules predict the new wall will fol...

journal_title：Biochemical Society transactions

authors： Serra L,Robinson S

更新日期：2020-12-18 00:00:00

abstract：:The identification of nitric oxide-bound leghaemoglobin within soya bean nodules has led to the question of how Bradyrhizobium japonicum bacteroids overcome the toxicity of this nitric oxide. It has previously been shown that one candidate for nitric oxide detoxification, the respiratory nitric oxide reductase, is exp...

journal_title：Biochemical Society transactions

authors： Meakin GE,Jepson BJ,Richardson DJ,Bedmar EJ,Delgado MJ

更新日期：2006-02-01 00:00:00

abstract：:The oxidoreductase Trx-1 (thioredoxin 1) is highly conserved and found intra- and extra-cellularly in mammalian systems. There is increasing interest in its capacity to regulate immune function based on observations of altered distribution and expression during ageing and disease. We have investigated previously wheth...

journal_title：Biochemical Society transactions

authors： Griffiths HR,Bennett SJ,Olofsson P,Dunston CR

更新日期：2014-08-01 00:00:00

abstract：:Lipids are key molecules for membranes, energy storage and signalling. I have been privileged to have worked in such a diverse field and in organisms from microbes to humans. Here I will describe some of those contrasting areas which range from environmental impacts to food production and on to human health. It has be...

journal_title：Biochemical Society transactions

authors： Harwood JL

更新日期：2017-04-15 00:00:00

abstract：:Protein L is a multidomain cell-wall protein isolated from Peptostreptococcus magnus. It belongs to a group of proteins that contain repeated domains that are able to bind to Igs without stimulating an immune response, the most characterized of this group being Protein A ( Staphylococcus aureus ) and Protein G ( Strep...

journal_title：Biochemical Society transactions

authors： Housden NG,Harrison S,Roberts SE,Beckingham JA,Graille M,Stura E,Gore MG

更新日期：2003-06-01 00:00:00

abstract：:Homologous recombination is essential for accurate chromosome segregation during meiosis in most sexual organisms. Meiotic recombination is initiated by the formation of DSBs (DNA double-strand breaks) made by the Spo11 protein. We review here recent findings pertaining to protein-protein interactions important for DS...

journal_title：Biochemical Society transactions

authors： Keeney S,Neale MJ

更新日期：2006-08-01 00:00:00

abstract：:Inflammation or inflammatory cytokines and oxidative stress have often been associated, and thiol antioxidants, particularly glutathione, have often been seen as possible anti-inflammatory mediators. However, whereas several cytokine inhibitors have been approved for drug use in chronic inflammatory diseases, this has...

journal_title：Biochemical Society transactions

authors： Coppo L,Ghezzi P

更新日期：2011-10-01 00:00:00

abstract：:The progression of Type 2 diabetes is accompanied by diminishing islet β-cell mass and function. It has been proposed that β-cells are lost not only through apoptosis, but also by dedifferentiating into progenitor-like cells. There is therefore much interest in the mechanisms which define and maintain β-cell identity....

journal_title：Biochemical Society transactions

authors： Pullen TJ,Rutter GA

更新日期：2013-06-01 00:00:00

abstract：:Membrane proteins are drug targets for a wide range of diseases. Having access to appropriate samples for further research underpins the pharmaceutical industry's strategy for developing new drugs. This is typically achieved by synthesizing a protein of interest in host cells that can be cultured on a large scale, all...

journal_title：Biochemical Society transactions

authors： Bawa Z,Bland CE,Bonander N,Bora N,Cartwright SP,Clare M,Conner MT,Darby RA,Dilworth MV,Holmes WJ,Jamshad M,Routledge SJ,Gross SR,Bill RM

更新日期：2011-06-01 00:00:00

abstract：:The protein kinase C (PKC) family of serine/threonine protein kinases share structural homology, while exhibiting substantial functional diversity. PKC isoforms are ubiquitously expressed in tissues which makes it difficult to define roles for individual isoforms, with complexity compounded by the finding that PKC iso...

journal_title：Biochemical Society transactions

authors： Tarafdar A,Michie AM

更新日期：2014-12-01 00:00:00

abstract：:In this study the network of ATP-consuming and -producing reactions, interacting via the cytosolic ATP/ADP+P(i) system, was studied for the first time in an intact organ, the isolated perfused rat liver, using top-down metabolic-control analysis. Flux control in the metabolically resting state (only oxidative phosphor...

journal_title：Biochemical Society transactions

authors： Soboll S,Brown GC

更新日期：2000-02-01 00:00:00

abstract：:The energy-converting NADH:ubiquinone oxidoreductase, also known as respiratory complex I, couples the transfer of electrons from NADH to ubiquinone with the translocation of ions across the membrane. It was assumed that the complex exclusively works as a proton pump. Recently, it has been proposed that complex I from...

journal_title：Biochemical Society transactions

authors： Friedrich T,Stolpe S,Schneider D,Barquera B,Hellwig P

更新日期：2005-08-01 00:00:00